Success Metrics

Clinical Success Rate
66.7%

Based on 6 completed trials

Completion Rate
67%(6/9)
Active Trials
1(8%)
Results Posted
83%(5 trials)
Terminated
3(23%)

Phase Distribution

Ph phase_1
2
15%
Ph phase_2
5
38%
Ph phase_4
5
38%

Phase Distribution

2

Early Stage

5

Mid Stage

5

Late Stage

Phase Distribution12 total trials
Phase 1Safety & dosage
2(16.7%)
Phase 2Efficacy & side effects
5(41.7%)
Phase 4Post-market surveillance
5(41.7%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

60.0%

6 of 10 finished

Non-Completion Rate

40.0%

4 ended early

Currently Active

1

trials recruiting

Total Trials

13

all time

Status Distribution
Active(2)
Completed(6)
Terminated(4)
Other(1)

Detailed Status

Completed6
Terminated3
Withdrawn1
Active, not recruiting1
unknown1
Not yet recruiting1

Development Timeline

Analytics

Development Status

Total Trials
13
Active
1
Success Rate
66.7%
Most Advanced
Phase 4

Trials by Phase

Phase 12 (16.7%)
Phase 25 (41.7%)
Phase 45 (41.7%)

Trials by Status

withdrawn18%
completed646%
active_not_recruiting18%
unknown18%
not_yet_recruiting18%
terminated323%

Recent Activity

Clinical Trials (13)

Showing 13 of 13 trials
NCT05203224Phase 2

Improving Early Reperfusion With Adjuvant Dornase Alfa in Large Vessel Ischemic Stroke (EXTEND-IA DNase)

Completed
NCT04488081Phase 2

I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill Patients

Active Not Recruiting
NCT05880524Phase 2

Reduction of SystemiC Inflammation After Ischemic Stroke by Intravenous DNase Administration (ReSCInD)

Not Yet Recruiting
NCT05139901Phase 4

Usefulness of DORNASE in COVID-19 on HFNO

Terminated
NCT04387786

Dornase Alfa Administered to Patients With COVID-19 (DACOVID)

Completed
NCT01357447Phase 1

Pulmozyme for Sjogren's Associated Cough

Withdrawn
NCT03586076Phase 1

A Comparative Safety and Pharmacokinetic Study of JHL1922 and Pulmozyme® in Healthy Subjects

Completed
NCT01952470Phase 2

Preliminary Study of Dornase Alfa to Treat Chest Infections Post Lung Transplant.

Completed
NCT01356147Phase 4

Dornase Alfa Therapy for Ventilator Associated Lung Infections in the Neonatal Intensive Care Unit (NICU)

Completed
NCT00434278Phase 4

A Trial of Pulmozyme Withdrawal on Exercise Tolerance in Cystic Fibrosis Subjects With Severe Lung Disease (TOPIC)

Terminated
NCT00680316Phase 4

A Study of Pulmozyme® (Dornase Alpha) in 3- to 5-Year-Old Patients With Cystic Fibrosis

Terminated
NCT02168387Phase 4

Efficacy of Percussive Ventilation Therapy (MetaNeb ®) Compared With Mucolytic Agents for Atelectasis in the Mechanically Ventilated Pediatric Patient

Completed
NCT00204685Phase 2

Time of Ventilation and Lung Function of Ventilated Patients Under Therapy With Dornase Alfa

Unknown

All 13 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
13