Success Metrics

Clinical Success Rate
75.0%

Based on 9 completed trials

Completion Rate
75%(9/12)
Active Trials
4(20%)
Results Posted
44%(4 trials)
Terminated
3(15%)

Phase Distribution

Ph phase_1
6
30%
Ph not_applicable
2
10%
Ph early_phase_1
1
5%
Ph phase_2
11
55%

Phase Distribution

7

Early Stage

11

Mid Stage

0

Late Stage

Phase Distribution20 total trials
Early Phase 1First-in-human
1(5.0%)
Phase 1Safety & dosage
6(30.0%)
Phase 2Efficacy & side effects
11(55.0%)
N/ANon-phased studies
2(10.0%)

Highest Phase Reached

Phase 2

Trial Status & Enrollment

Completion Rate

69.2%

9 of 13 finished

Non-Completion Rate

30.8%

4 ended early

Currently Active

4

trials recruiting

Total Trials

20

all time

Status Distribution
Active(4)
Completed(9)
Terminated(4)
Other(3)

Detailed Status

Completed9
Terminated3
Recruiting3
unknown2
Suspended1
Withdrawn1

Development Timeline

Analytics

Development Status

Total Trials
20
Active
4
Success Rate
75.0%
Most Advanced
Phase 2

Trials by Phase

Early Phase 11 (5.0%)
Phase 16 (30.0%)
Phase 211 (55.0%)
N/A2 (10.0%)

Trials by Status

completed945%
unknown210%
terminated315%
suspended15%
withdrawn15%
active_not_recruiting15%
recruiting315%

Recent Activity

Clinical Trials (20)

Showing 20 of 20 trials
NCT05327023Phase 1

Donor Lymphocyte Infusion After Allogeneic Hematopoietic Cell Transplantation for High-Risk Hematologic Malignancies

Recruiting
NCT06297629Phase 2

A Phase I/II Trial to Assess the Efficacy and Toxicity of ASTX727 (Oral Decitabine/Cedazuridine) for the Treatment of Hematological Neoplasms After Allogeneic Stem Cell Transplantation

Withdrawn
NCT03032783Phase 2

A Two Step Approach to Allogeneic Hematopoietic Stem Cell Transplantation for Patients With Hematologic Malignancies-Increasing GVT Effects Without Increasing Toxicity

Completed
NCT05772273Not Applicable

PD-1 Inhibitor, Azacitidine and Low-dose DLI in AML Relapse After Allo-HSCT

Recruiting
NCT05031897Phase 2

Two Step Haplo With Radiation Conditioning

Recruiting
NCT03712878Phase 2

2-Step Approach to Stem Cell Transplant in Treating Participants With Hematological Malignancies

Completed
NCT06158100Phase 1

Venetoclax in Combination With Azacitidine (VEN/AZA) Followed by Donor Lymphocyte Infusion (DLI) for Patients With Very High-Risk Acute Myeloid Leukemia (AML) Undergoing Allogeneic Hematopoietic Cell Transplant (HCT)

Suspended
NCT03597594Phase 1

Haplocompatible Transplant Using TCRα/β Depletion Followed by CD45RA-Depleted Donor Lymphocyte Infusions for Severe Combined Immunodeficiency (SCID)

Active Not Recruiting
NCT03537599Phase 1

Daratumumab and Donor Lymphocyte Infusion in Treating Participants With Relapsed Acute Myeloid Leukemia After Stem Cell Transplant

Terminated
NCT04582864Phase 2

Flotetuzumab for Relapsed Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) Following Allogeneic Hematopoietic Cell Transplantation (Allo-HCT)

Terminated
NCT01025778Phase 2

Haploidentical Stem Cell Transplantation for Children With Therapy Resistant Leukemia

Completed
NCT00790413Early Phase 1

Haploidentical Stem Cell Transplantation in Neuroblastoma

Unknown
NCT02458235Phase 2

Donor Lymphocyte Infusion With Azacitidine to Prevent Hematologic Malignancy Relapse After Stem Cell Transplantation

Completed
NCT03297528Phase 2

Chemotherapy and DLI for Prevention of Second Relapse in Patients With Relapsed Acute Leukemia After Allotransplant

Unknown
NCT02673008Phase 2

MRD-directed Donor Lymphocyte Infusion for Reduce of Relapse After Allo-HSCT

Completed
NCT02017457Phase 2

Azacytidine and Lymphocytes in Relapse of AML or MDS After Allogeneic Stem Cell Transplantation.

Completed
NCT00167180Phase 2

Post Transplant Donor Lymphocyte Infusion

Terminated
NCT00167167Not Applicable

Donor Lymphocyte Infusion (DLI) for Relapsed (Post Transplant) Leukemia

Completed
NCT01086735Phase 1

Suicide Gene Therapy for Donor Lymphocytes Infusion After Allogeneic Hematopoietic Stem Cell Transplantation

Completed
NCT00987987Phase 1

Amplifying Graft-Versus-Tumor Effect by Donor Regulatory T-Cell Depletion Before Donor Lymphocytes Infusion

Completed

All 20 trials loaded

Drug Details

Intervention Type
PROCEDURE
Total Trials
20