Success Metrics

Clinical Success Rate
33.3%

Based on 2 completed trials

Completion Rate
33%(2/6)
Active Trials
7(27%)
Results Posted
0%(0 trials)
Terminated
4(15%)

Phase Distribution

Ph phase_3
2
8%
Ph phase_1
3
12%
Ph not_applicable
2
8%
Ph phase_2
14
54%
Ph phase_4
2
8%

Phase Distribution

3

Early Stage

14

Mid Stage

4

Late Stage

Phase Distribution23 total trials
Phase 1Safety & dosage
3(13.0%)
Phase 2Efficacy & side effects
14(60.9%)
Phase 3Large-scale testing
2(8.7%)
Phase 4Post-market surveillance
2(8.7%)
N/ANon-phased studies
2(8.7%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

33.3%

2 of 6 finished

Non-Completion Rate

66.7%

4 ended early

Currently Active

7

trials recruiting

Total Trials

26

all time

Status Distribution
Active(11)
Completed(2)
Terminated(4)
Other(9)

Detailed Status

unknown9
Recruiting7
Terminated4
Not yet recruiting4
Completed2

Development Timeline

Analytics

Development Status

Total Trials
26
Active
7
Success Rate
33.3%
Most Advanced
Phase 4

Trials by Phase

Phase 13 (13.0%)
Phase 214 (60.9%)
Phase 32 (8.7%)
Phase 42 (8.7%)
N/A2 (8.7%)

Trials by Status

terminated415%
not_yet_recruiting415%
completed28%
recruiting727%
unknown935%

Recent Activity

Clinical Trials (26)

Showing 20 of 26 trialsScroll for more
NCT07353827Phase 2

FOLFOX-HAIC Combined With Donafenib and Pucotenlimab as First-Line Treatment for Unresectable Intrahepatic Cholangiocarcinoma

Not Yet Recruiting
NCT05171166Phase 2

Neoadjuvant HAIC of TACE Plus Donafenib in BCLC B Stage HCC: a Multi-center Randomized Controlled Trial.

Terminated
NCT07180459

The Treatment of Unresectable Liver Cancer With E-TACE Combined With Donafenib:A Prospective, Single-arm, Multicenter, Observational Study

Not Yet Recruiting
NCT05713994

Combined HAIC, TKI/Anti-VEGF and ICIs as Conversion Therapy for Unresectable Hepatocellular Carcinoma

Recruiting
NCT06685289Phase 2

Donafenib Combined With Capecitabine for Postoperative Adjuvant Therapy of Biliary Malignant Tumors With High-risk Recurrence Risk

Recruiting
NCT06482086Phase 2

Efficacy of Organoid-Based Drug Screening to Guide Treatment for Locally Advanced Thyroid Cancer

Recruiting
NCT06609876Not Applicable

Donafenib as Adjuvant Therapy Following Ablation for Recurrent HCC

Recruiting
NCT06646198Phase 2

TIPS Plus Half-dose Donafenib in AHCC with PVTT-associated Portal Hypertension

Recruiting
NCT06581315Not Applicable

Postoperative Adjuvant Therapy of Donafenib for Hepatocellular Carcinoma

Recruiting
NCT06512467Phase 2

Donafenib Combine With Sintilimab and HAIC in Neoadjuvant of Resectable Hepatocellular Carcinoma

Not Yet Recruiting
NCT06496815Phase 4

Donafenib Combined With Immunotherapy and Local Therapy for Unresectable Hepatocellular Carcinoma That Has Failed in Previous Therapy

Not Yet Recruiting
NCT05717738

Combined TACE, TKI/Anti-VEGF and ICIs as Conversion Therapy for Advanced Hepatocellular Carcinoma

Recruiting
NCT05576909Phase 2

Donafenib Combined With Hepatic Artery Chemoembolization for Perioperative Treatment of Liver Transplantation

Unknown
NCT04962958Phase 2

Hepatic Artery Infusion Chemotherapy Plus Donafenib in Patients With Hepatocellular Carcinoma After Surgery

Unknown
NCT02698111Phase 1

Donafenib Monotherapy for Previously Treated Metastatic Nasopharyngeal Carcinoma

Terminated
NCT04402723Phase 1

Combination of Donafenib and Cytarabine/Daunorubicin in Relapsed AML

Terminated
NCT04472858Phase 1

A Study of CS1001 in Combination With Donafenib in Subjects With Advanced Solid Tumors

Unknown
NCT02870582Phase 3

Donafenib for Previously Treated Metastatic Colorectal Cancer

Completed
NCT05350943Phase 2

HAIC Combined With Toripalimab and Donafenib for Advanced BTC

Unknown
NCT05493332Phase 2

HAIC Combined With Donafenib Tosilate and Toripalimab for Unresectable HCC

Unknown

Drug Details

Intervention Type
DRUG
Total Trials
26