Success Metrics

Clinical Success Rate
82.4%

Based on 14 completed trials

Completion Rate
82%(14/17)
Active Trials
0(0%)
Results Posted
50%(7 trials)
Terminated
3(15%)

Phase Distribution

Ph phase_2
14
70%
Ph phase_1
4
20%
Ph early_phase_1
1
5%
Ph not_applicable
1
5%

Phase Distribution

5

Early Stage

14

Mid Stage

0

Late Stage

Phase Distribution20 total trials
Early Phase 1First-in-human
1(5.0%)
Phase 1Safety & dosage
4(20.0%)
Phase 2Efficacy & side effects
14(70.0%)
N/ANon-phased studies
1(5.0%)

Highest Phase Reached

Phase 2

Trial Status & Enrollment

Completion Rate

73.7%

14 of 19 finished

Non-Completion Rate

26.3%

5 ended early

Currently Active

0

trials recruiting

Total Trials

20

all time

Status Distribution
Completed(14)
Terminated(5)
Other(1)

Detailed Status

Completed14
Terminated3
Withdrawn2
unknown1

Development Timeline

Analytics

Development Status

Total Trials
20
Active
0
Success Rate
82.4%
Most Advanced
Phase 2

Trials by Phase

Early Phase 11 (5.0%)
Phase 14 (20.0%)
Phase 214 (70.0%)
N/A1 (5.0%)

Trials by Status

completed1470%
terminated315%
unknown15%
withdrawn210%

Recent Activity

Clinical Trials (20)

Showing 20 of 20 trials
NCT00003615Phase 2

Denileukin Diftitox in Treating Patients With Non-Hodgkin's Lymphoma

Completed
NCT00945269Phase 1

Therapeutic Autologous Lymphocytes, Aldesleukin, and Denileukin Diftitox in Treating Patients With Stage III-IV Melanoma

Terminated
NCT01127451Phase 2

Study of Denileukin Diftitox in Participants With Stage IIIC and Stage IV Melanoma

Completed
NCT00224874Phase 2

Treatment for Acute Graft-Versus-Host Disease (BMT CTN 0302)

Completed
NCT00632827Phase 2

Treatment of PTCL With Aggressive Induction Therapy Followed by Autologous SCT Using Denileukin Diftitox (Ontak)

Terminated
NCT00211185Phase 2

A Study of ONTAK and CHOP in Newly Diagnosed, Peripheral T-Cell Lymphoma

Completed
NCT00357448Phase 1

Denileukin Diftitox Used in Treating Patients With Advanced Refractory Ovarian Cancer, Primary Peritoneal Carcinoma, or Epithelial Fallopian Tube Cancer

Completed
NCT01106950Phase 2

Haploidentical Natural Killer Cells to Treat Refractory or Relapsed Acute Myelogenous Leukemia (AML)

Terminated
NCT00460109Phase 2

Rituximab and Denileukin Diftitox in Treating Patients With Previously Untreated Stage III or Stage IV Follicular B-Cell Non-Hodgkin's Lymphoma

Completed
NCT00082940Phase 2

Denileukin Diftitox in Treating Patients With Fludarabine-Refractory B-Cell Chronic Lymphocytic Leukemia

Completed
NCT00513188Not Applicable

Combination Chemotherapy and Denileukin Diftitox in Treating Patients With Newly Diagnosed T-Cell Non-Hodgkin Lymphoma

Withdrawn
NCT00228358Phase 1

Cyclophosphamide or Denileukin Diftitox Followed By Expanding a Patient's Own T Cells in the Laboratory in Treating Patients With HER-2/Neu Overexpressing Metastatic Breast Cancer, Ovarian Cancer, or Non-Small Cell Lung Cancer Previously Treated With HER-2/Neu Vaccine

Completed
NCT00299689Phase 2

Phase II Trial of Ontak With Metastatic Melanoma

Completed
NCT00026429Phase 2

Denileukin Diftitox in Treating Patients With Non-Hodgkin's Lymphoma

Unknown
NCT00082914Phase 2

Denileukin Diftitox in Treating Patients With Metastatic Melanoma or Metastatic Kidney Cancer

Completed
NCT00006345Phase 2

Dexamethasone Followed by Denileukin Diftitox in Treating Patients With Persistent or Recurrent T-Cell Lymphoma

Completed
NCT00138164Phase 2

Denileukin Diftitox in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma

Completed
NCT00278369Early Phase 1

Pilot Study of Denileukin Diftitox Plus High-Dose IL-2 for Patients With Metastatic Renal Cancer

Completed
NCT00801918Phase 2

Denileukine Diftitox for Relapsed ALCL

Withdrawn
NCT00128622Phase 1

Denileukin Diftitox Followed by Vaccine Therapy in Treating Patients With Metastatic Cancer

Completed

All 20 trials loaded

Drug Details

Intervention Type
BIOLOGICAL
Total Trials
20