Success Metrics

Clinical Success Rate
74.2%

Based on 118 completed trials

Completion Rate
74%(118/159)
Active Trials
61(21%)
Results Posted
71%(84 trials)
Terminated
41(14%)

Phase Distribution

Ph early_phase_1
4
1%
Ph phase_1
136
47%
Ph not_applicable
5
2%
Ph phase_2
114
39%
Ph phase_3
23
8%
Ph phase_4
6
2%

Phase Distribution

140

Early Stage

114

Mid Stage

29

Late Stage

Phase Distribution288 total trials
Early Phase 1First-in-human
4(1.4%)
Phase 1Safety & dosage
136(47.2%)
Phase 2Efficacy & side effects
114(39.6%)
Phase 3Large-scale testing
23(8.0%)
Phase 4Post-market surveillance
6(2.1%)
N/ANon-phased studies
5(1.7%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

68.2%

118 of 173 finished

Non-Completion Rate

31.8%

55 ended early

Currently Active

61

trials recruiting

Total Trials

292

all time

Status Distribution
Active(71)
Completed(118)
Terminated(55)
Other(48)

Detailed Status

Completed118
unknown43
Terminated41
Recruiting39
Active, not recruiting22
Withdrawn14

Development Timeline

Analytics

Development Status

Total Trials
292
Active
61
Success Rate
74.2%
Most Advanced
Phase 4

Trials by Phase

Early Phase 14 (1.4%)
Phase 1136 (47.2%)
Phase 2114 (39.6%)
Phase 323 (8.0%)
Phase 46 (2.1%)
N/A5 (1.7%)

Trials by Status

recruiting3913%
completed11840%
unknown4315%
not_yet_recruiting103%
active_not_recruiting228%
suspended52%
terminated4114%
withdrawn145%

Recent Activity

Clinical Trials (292)

Showing 20 of 292 trialsScroll for more
NCT06445959Phase 1

Phase 1b/2 Study of Decitabine and Venetoclax in Combination With the Targeted Mutant IDH1 Inhibitor Olutasidenib

Recruiting
NCT05201066Phase 2

Roll-over Study for Patients Who Have Completed a Prior Novartis-sponsored Sabatolimab (MBG453) Study and Are Judged by the Investigator to Benefit From Continued Treatment With Sabatolimab.

Active Not Recruiting
NCT06561074Phase 2

A Phase 2 Study to Evaluate Efficacy of Calaspargase Pegol-mknl and Decitabine Combined With Venetoclax in Pediatric, Adolescent, and Young Adult Patients With Relapsed/Refractory T-cell Acute Lymphoblastic Leukemia (T-ALL) and T- Cell Lymphoblastic Lymphoma (T-LLy)

Recruiting
NCT03661307Phase 1

Quizartinib, Decitabine, and Venetoclax in Treating Participants With Untreated or Relapsed Acute Myeloid Leukemia or High Risk Myelodysplastic Syndrome

Suspended
NCT04874480Phase 1

Tegavivint for the Treatment of Relapsed or Refractory Leukemia

Active Not Recruiting
NCT01515527Phase 2

Cladribine Plus Low Dose Cytarabine (LDAC) Alternating With Decitabine in Patients With Acute Myeloid Leukemia (AML) or High-Risk Myelodysplastic Syndrome (MDS)

Recruiting
NCT06997094Phase 1

Decitabine in Combination With Standard of Care Therapy for the Treatment of Surgically Resectable HPV-Negative Head and Neck Cancer

Recruiting
NCT05038592Phase 1

Phase I/II Study of Tagraxofusp in Combination With Decitabine for Patients With Myelomonocytic/Myeloproliferative Neoplasm and High Risk Myelodysplastic Syndromes

Active Not Recruiting
NCT03969446Phase 1

Pembrolizumab and Decitabine With or Without Venetoclax in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome That Is Newly-Diagnosed, Recurrent, or Refractory

Suspended
NCT02650986Phase 1

Gene-Modified T Cells With or Without Decitabine in Treating Patients With Advanced Malignancies Expressing NY-ESO-1

Active Not Recruiting
NCT01861314Phase 1

Bortezomib, Sorafenib Tosylate, and Decitabine in Treating Patients With Acute Myeloid Leukemia

Active Not Recruiting
NCT07012044Phase 1

A Study to Find the Highest Dose of Cedazuridine and Decitabine Combination With Filgrastim as a Treatment Option After Hematopoietic Stem Cell Transplant in Children With High-Risk Acute Myeloid Leukemia

Recruiting
NCT02957968Phase 2

Neoadjuvant Pembrolizumab + Decitabine Followed by Std Neoadj Chemo for Locally Advanced HER2- Breast Ca

Active Not Recruiting
NCT07216833Phase 1

Decitabine and Nivolumab in Participants With Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck

Withdrawn
NCT06383572Phase 1

Phase I/II Study of Engineered T Cell Receptor-Modified NK Cells Targeting PRAME in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapse/Refractory Myeloid Malignancies

Recruiting
NCT03041688Phase 1

Testing a New Chemotherapy Drug, KRT-232 (AMG-232) in Combination With Decitabine and Venetoclax in Patients With Acute Myeloid Leukemia

Active Not Recruiting
NCT03146871Phase 2

Recombinant EphB4-HSA Fusion Protein and Azacitidine or Decitabine for Relapsed or Refractory Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia, or Acute Myeloid Leukemia Patients Previously Treated With a Hypomethylating Agent

Terminated
NCT04188405Phase 2

Decitabine, Venetoclax, and Ponatinib for the Treatment of Philadelphia Chromosome-Positive Acute Myeloid Leukemia or Myeloid Blast Phase or Accelerated Phase Chronic Myelogenous Leukemia

Completed
NCT07617363Phase 1

ATRN-119 in Combination With Decitabine in Patients With TP53-Mutated AML or Higher-Risk MDS

Not Yet Recruiting
NCT05564650Phase 1

Navitoclax in Relapsed or Refractory High-Risk Myelodysplastic Syndrome

Completed

Drug Details

Intervention Type
DRUG
Total Trials
292