Success Metrics

Clinical Success Rate
74.4%

Based on 119 completed trials

Completion Rate
74%(119/160)
Active Trials
62(21%)
Results Posted
71%(84 trials)
Terminated
41(14%)

Phase Distribution

Ph phase_4
7
2%
Ph not_applicable
5
2%
Ph phase_2
114
39%
Ph phase_1
136
46%
Ph early_phase_1
4
1%
Ph phase_3
23
8%

Phase Distribution

140

Early Stage

114

Mid Stage

30

Late Stage

Phase Distribution289 total trials
Early Phase 1First-in-human
4(1.4%)
Phase 1Safety & dosage
136(47.1%)
Phase 2Efficacy & side effects
114(39.4%)
Phase 3Large-scale testing
23(8.0%)
Phase 4Post-market surveillance
7(2.4%)
N/ANon-phased studies
5(1.7%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

68.4%

119 of 174 finished

Non-Completion Rate

31.6%

55 ended early

Currently Active

62

trials recruiting

Total Trials

293

all time

Status Distribution
Active(72)
Completed(119)
Terminated(55)
Other(47)

Detailed Status

Completed119
unknown43
Terminated41
Recruiting37
Active, not recruiting25
Withdrawn14

Development Timeline

Analytics

Development Status

Total Trials
293
Active
62
Success Rate
74.4%
Most Advanced
Phase 4

Trials by Phase

Early Phase 14 (1.4%)
Phase 1136 (47.1%)
Phase 2114 (39.4%)
Phase 323 (8.0%)
Phase 47 (2.4%)
N/A5 (1.7%)

Trials by Status

recruiting3713%
completed11941%
suspended41%
terminated4114%
active_not_recruiting259%
unknown4315%
not_yet_recruiting103%
withdrawn145%

Recent Activity

Clinical Trials (293)

Showing 20 of 293 trialsScroll for more
NCT03418038Phase 2

Ascorbic Acid and Chemotherapy for the Treatment of Relapsed or Refractory Lymphoma, CCUS, and Chronic Myelomonocytic Leukemia

Recruiting
NCT06401603Phase 1

A Phase I Study of Decitabine, Lisaftoclax, and Olverembatinib in Patients With Advanced Chronic Myeloid Leukemia and Philadelphia Chromosome-Positive Acute Myeloid Leukemia

Recruiting
NCT03661307Phase 1

Quizartinib, Decitabine, and Venetoclax in Treating Participants With Untreated or Relapsed Acute Myeloid Leukemia or High Risk Myelodysplastic Syndrome

Recruiting
NCT06445959Phase 1

Phase 1b/2 Study of Decitabine and Venetoclax in Combination With the Targeted Mutant IDH1 Inhibitor Olutasidenib

Recruiting
NCT07012044Phase 1

A Study to Find the Highest Dose of Cedazuridine and Decitabine Combination With Filgrastim as a Treatment Option After Hematopoietic Stem Cell Transplant in Children With High-Risk Acute Myeloid Leukemia

Recruiting
NCT05201066Phase 2

Roll-over Study for Patients Who Have Completed a Prior Novartis-sponsored Sabatolimab (MBG453) Study and Are Judged by the Investigator to Benefit From Continued Treatment With Sabatolimab.

Active Not Recruiting
NCT06561074Phase 2

A Phase 2 Study to Evaluate Efficacy of Calaspargase Pegol-mknl and Decitabine Combined With Venetoclax in Pediatric, Adolescent, and Young Adult Patients With Relapsed/Refractory T-cell Acute Lymphoblastic Leukemia (T-ALL) and T- Cell Lymphoblastic Lymphoma (T-LLy)

Recruiting
NCT00801489Phase 2

Fludarabine Phosphate, Cytarabine, Filgrastim-sndz, Gemtuzumab Ozogamicin, and Idarubicin Hydrochloride in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

Recruiting
NCT04282187Phase 2

Decitabine With Ruxolitinib, Fedratinib or Pacritinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms

Recruiting
NCT01861314Phase 1

Bortezomib, Sorafenib Tosylate, and Decitabine in Treating Patients With Acute Myeloid Leukemia

Active Not Recruiting
NCT06383572Phase 1

Phase I/II Study of Engineered T Cell Receptor-Modified NK Cells Targeting PRAME in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapse/Refractory Myeloid Malignancies

Recruiting
NCT02890329Phase 1

Ipilimumab and Decitabine in Treating Patients With Relapsed or Refractory Myelodysplastic Syndrome or Acute Myeloid Leukemia

Active Not Recruiting
NCT06429098Phase 2

Study of A Venetoclax-based, Anthracycline-free Regimen in Newly Diagnosed CBFβ::MYH11(+) AML

Active Not Recruiting
NCT03875287Phase 1

Dose-Escalation Study of E7727, an Oral Cytidine Deaminase Inhibitor With Oral Decitabine in Subjects With Solid Tumors

Active Not Recruiting
NCT06930651Phase 1

A Phase I/II Study of CAR.70-Engineered IL15-Transduced Cord Blood-Derived NK Cells With TGF-beta Receptor 2 (TGFBR2) Knock Out in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapsed/Refractory Myeloid Malignancies

Recruiting
NCT07177079Phase 1

High-dose Ascorbate (HDA) in Combination With Standard of Care Azacitidine and Venetoclax in Acute Myeloid Leukemia (AML)

Recruiting
NCT07163793Phase 2

Pilot Study of Reduced Venetoclax Exposure

Active Not Recruiting
NCT00095784Phase 2

Decitabine in Treating Patients With Myelofibrosis

Active Not Recruiting
NCT04874480Phase 1

Tegavivint for the Treatment of Relapsed or Refractory Leukemia

Active Not Recruiting
NCT07773909Phase 4

Venetoclax With Hypomethylating Agents in Newly Diagnosed AML Unfit for Intensive Chemotherapy

Completed

Drug Details

Intervention Type
DRUG
Total Trials
293