Success Metrics

Clinical Success Rate
88.9%

Based on 16 completed trials

Completion Rate
89%(16/18)
Active Trials
4(17%)
Results Posted
50%(8 trials)
Terminated
2(9%)

Phase Distribution

Ph phase_3
3
13%
Ph phase_2
7
30%
Ph phase_1
10
43%

Phase Distribution

10

Early Stage

7

Mid Stage

3

Late Stage

Phase Distribution20 total trials
Phase 1Safety & dosage
10(50.0%)
Phase 2Efficacy & side effects
7(35.0%)
Phase 3Large-scale testing
3(15.0%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

88.9%

16 of 18 finished

Non-Completion Rate

11.1%

2 ended early

Currently Active

4

trials recruiting

Total Trials

23

all time

Status Distribution
Active(4)
Completed(16)
Terminated(2)
Other(1)

Detailed Status

Completed16
Active, not recruiting3
Terminated2
unknown1
Recruiting1

Development Timeline

Analytics

Development Status

Total Trials
23
Active
4
Success Rate
88.9%
Most Advanced
Phase 3

Trials by Phase

Phase 110 (50.0%)
Phase 27 (35.0%)
Phase 33 (15.0%)

Trials by Status

completed1670%
active_not_recruiting313%
terminated29%
unknown14%
recruiting14%

Recent Activity

Clinical Trials (23)

Showing 20 of 23 trialsScroll for more
NCT05389449Phase 3

A Long-term Safety and Efficacy Study of Danicopan as an Add-on Therapy to Complement Component 5 Inhibitor (C5i) in Participants With PNH

Active Not Recruiting
NCT05982938

Danicopan Early Access Program

Unknown
NCT07413250

Assess Long-Term Safety of Danicopan Add-on Therapy in Participants With Paroxysmal Nocturnal Hemoglobinuria: Analysis of IPIG-Registry Data

Active Not Recruiting
NCT07413679

Long-term Safety of Danicopan: IPIG Registry-based Cohort Study

Active Not Recruiting
NCT06449001Phase 3

Study of Danicopan as Add-on Treatment to Ravulizumab or Eculizumab in Pediatric Participants With PNH Who Have Clinically Significant Extravascular Hemolysis

Recruiting
NCT05019521Phase 2

A Study of Danicopan in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration

Terminated
NCT04469465Phase 3

Danicopan as Add-on Therapy to a C5 Inhibitor in Paroxysmal Nocturnal Hemoglobinuria (PNH) Participants Who Have Clinically Evident Extravascular Hemolysis (EVH)(ALPHA)

Completed
NCT03472885Phase 2

Study of Danicopan in Participants With Paroxysmal Nocturnal Hemoglobinuria With Inadequate Response to Eculizumab

Completed
NCT03459443Phase 2

A Proof of Concept Study for a 12 Month Treatment in Patients With C3G or IC-MPGN Treated With ACH-0144471

Terminated
NCT04988035Phase 2

ACTIV-5 / Big Effect Trial (BET-C) for the Treatment of COVID-19

Completed
NCT04551599Phase 1

A Study of the Effects of Food and Age on Danicopan

Completed
NCT03369236Phase 2

A Proof-of-Concept Study of Danicopan for 6 Months of Treatment in Participants With C3 Glomerulopathy (C3G)

Completed
NCT03053102Phase 2

Study of Danicopan in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Completed
NCT05109390Phase 1

A Study of the Drug Interactions Between Danicopan and Cyclosporine, Tacrolimus, Antacids, and Omeprazole in Healthy Adults

Completed
NCT03124368Phase 2

A Proof-of-Mechanism Study to Determine the Effect of Danicopan on C3 Levels in Participants With C3G or IC-MPGN

Completed
NCT05016206Phase 1

A Study of the Cardiac Effects of Danicopan in Healthy Adults

Completed
NCT03555539Phase 1

Study of Danicopan in Participants With Hepatic Impairment

Completed
NCT03108274Phase 1

A Drug Interaction Study Between Danicopan and Midazolam, Fexofenadine, and Mycophenolate Mofetil in Healthy Participants

Completed
NCT04935294Phase 1

Study of Danicopan in Participants With Normal Kidney Function and Participants With Kidney Dysfunction

Completed
NCT04889690Phase 1

Study of Multiple Doses of Danicopan in Healthy Participants

Completed

Drug Details

Intervention Type
DRUG
Total Trials
23