Success Metrics

Clinical Success Rate
40.0%

Based on 10 completed trials

Completion Rate
40%(10/25)
Active Trials
11(25%)
Results Posted
140%(14 trials)
Terminated
15(34%)

Phase Distribution

Ph phase_1
28
64%
Ph phase_2
15
34%
Ph early_phase_1
1
2%

Phase Distribution

29

Early Stage

15

Mid Stage

0

Late Stage

Phase Distribution44 total trials
Early Phase 1First-in-human
1(2.3%)
Phase 1Safety & dosage
28(63.6%)
Phase 2Efficacy & side effects
15(34.1%)

Highest Phase Reached

Phase 2

Trial Status & Enrollment

Completion Rate

31.3%

10 of 32 finished

Non-Completion Rate

68.8%

22 ended early

Currently Active

11

trials recruiting

Total Trials

44

all time

Status Distribution
Active(11)
Completed(10)
Terminated(22)
Other(1)

Detailed Status

Terminated15
Active, not recruiting11
Completed10
Withdrawn7
unknown1

Development Timeline

Analytics

Development Status

Total Trials
44
Active
11
Success Rate
40.0%
Most Advanced
Phase 2

Trials by Phase

Early Phase 11 (2.3%)
Phase 128 (63.6%)
Phase 215 (34.1%)

Trials by Status

withdrawn716%
completed1023%
active_not_recruiting1125%
terminated1534%
unknown12%

Recent Activity

Clinical Trials (44)

Showing 20 of 44 trialsScroll for more
NCT02465060Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

Active Not Recruiting
NCT06360588Phase 2

Testing Copanlisib as Potentially Targeting Treatment in Cancers With PTEN Loss (MATCH - Subprotocol Z1G)

Active Not Recruiting
NCT06400238Phase 2

Testing Copanlisib as Potentially Targeting Treatment in Cancers With PTEN Expression (MATCH - Subprotocol Z1H)

Active Not Recruiting
NCT03502733Phase 1

Testing the Combination of Copanlisib, Nivolumab and Ipilimumab in Patients With Advanced Cancer and Lymphoma

Active Not Recruiting
NCT03474744Phase 2

Copanlisib and Rituximab in Marginal Zone Lymphoma Patients

Active Not Recruiting
NCT02705859Phase 1

Phase Ib/II Trial of coPANlisib in Combination With Trastuzumab in HER2-positive Breast Cancer. (Panther Study)

Completed
NCT03586661Phase 1

Niraparib and Copanlisib in Treating Patients With Recurrent Endometrial, Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

Active Not Recruiting
NCT03789240Phase 2

Response-Adapted Therapy With Copanlisib and Rituximab in Untreated Follicular Lymphoma

Active Not Recruiting
NCT03581942Phase 1

Copanlisib With Ibrutinib for Patients With Recurrent/ Refractory Primary Central Nervous System Lymphoma (PCNSL)

Completed
NCT05082025Phase 2

Phase 2 Study of PI3K Inhibitor Copanlisib in Combination With Fulvestrant in Selected ER+ and/or PR+ Cancers With PI3K (PIK3CA, PIK3R1) and/or PTEN Alterations

Terminated
NCT04572763Phase 1

Copanlisib Plus Venetoclax in R/R DLBCL

Active Not Recruiting
NCT03884998Phase 1

Copanlisib and Nivolumab in Treating Patients With Richter's Transformation or Transformed Indolent Non-Hodgkin Lymphoma

Active Not Recruiting
NCT04895579Phase 1

Lung Cancer With Copanlisib and Durvalumab

Completed
NCT04108858Phase 1

Testing the Addition of an Anti-cancer Drug, Copanlisib, to the Usual Maintenance Treatment (Trastuzumab and Pertuzumab) After Initial Chemotherapy in a Phase Ib/II Trial for Advanced HER2 Positive Breast Cancer

Terminated
NCT03711058Phase 1

Study of PI3Kinase Inhibition (Copanlisib) and Anti-PD-1 Antibody Nivolumab in Relapsed/Refractory Solid Tumors With Expansions in Mismatch-repair Proficient (MSS) Colorectal Cancer

Completed
NCT04462471Phase 1

Vemurafenib Plus Copanlisib in Radioiodine-Refractory (RAIR) Thyroid Cancers

Completed
NCT04433182Phase 2

Copanlisib With Rituximab-Bendamustine in Patients With Relapsed-Refractory Diffuse Large B-cell Lymphoma

Terminated
NCT04042051Phase 1

Copanlisib in Combination With T-DM1 in Pretreated Unresectable Locally Advanced or Metastatic HER2-positive Breast Cancer

Terminated
NCT05687721Phase 1

Copanlisib and Avelumab as a Maintenance Therapy for Advanced Bladder Cancer

Withdrawn
NCT04685915Phase 2

Copanlisib Plus Ibrutinib or Acalabrutinib in R/R CLL

Withdrawn

Drug Details

Intervention Type
DRUG
Total Trials
44