Success Metrics

Clinical Success Rate
75.4%

Based on 49 completed trials

Completion Rate
75%(49/65)
Active Trials
23(24%)
Results Posted
84%(41 trials)
Terminated
16(17%)

Phase Distribution

Ph phase_3
7
7%
Ph not_applicable
1
1%
Ph phase_2
43
45%
Ph early_phase_1
2
2%
Ph phase_1
40
42%

Phase Distribution

42

Early Stage

43

Mid Stage

7

Late Stage

Phase Distribution93 total trials
Early Phase 1First-in-human
2(2.2%)
Phase 1Safety & dosage
40(43.0%)
Phase 2Efficacy & side effects
43(46.2%)
Phase 3Large-scale testing
7(7.5%)
N/ANon-phased studies
1(1.1%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

71.0%

49 of 69 finished

Non-Completion Rate

29.0%

20 ended early

Currently Active

23

trials recruiting

Total Trials

95

all time

Status Distribution
Active(23)
Completed(49)
Terminated(20)
Other(3)

Detailed Status

Completed49
Terminated16
Active, not recruiting15
Recruiting8
Withdrawn4
unknown3

Development Timeline

Analytics

Development Status

Total Trials
95
Active
23
Success Rate
75.4%
Most Advanced
Phase 3

Trials by Phase

Early Phase 12 (2.2%)
Phase 140 (43.0%)
Phase 243 (46.2%)
Phase 37 (7.5%)
N/A1 (1.1%)

Trials by Status

terminated1617%
unknown33%
completed4952%
recruiting88%
withdrawn44%
active_not_recruiting1516%

Recent Activity

Clinical Trials (95)

Showing 20 of 95 trialsScroll for more
NCT03768063Phase 3

A Study in Patients Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study

Active Not Recruiting
NCT03181100Phase 2

Atezolizumab With Chemotherapy in Treating Patients With Anaplastic or Poorly Differentiated Thyroid Cancer

Active Not Recruiting
NCT05034627Phase 1

Calaspargase Pegol-Mnkl and Cobimetinib for the Treatment of Locally Advanced or Metastatic Pancreatic Cancer

Completed
NCT04409639Phase 2

Cobimetinib in Newly Diagnosed or HMA-treated CMML Patients With RAS Pathway Mutations

Active Not Recruiting
NCT04302025Phase 2

A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)

Recruiting
NCT04835805Phase 1

A Study to Evaluate the Safety and Activity of Belvarafenib as a Single Agent and in Combination With Either Cobimetinib or Cobimetinib Plus Nivolumab in Patients With NRAS-mutant Advanced Melanoma.

Active Not Recruiting
NCT03175432Phase 2

Bevacizumab and Atezolizumab With or Without Cobimetinib in Treating Patients With Untreated Melanoma Brain Metastases

Active Not Recruiting
NCT06813079Phase 2

Using Tumor Models to Determine Treatments

Recruiting
NCT03202316Phase 2

Atezolizumab, Cobimetinib, and Eribulin in Treating Patients With Chemotherapy Resistant Metastatic Inflammatory Breast Cancer

Active Not Recruiting
NCT03224767Phase 2

Vemurafenib and Cobimetinib in Treating Patients With BRAF V600E Mutation Positive Craniopharyngioma

Active Not Recruiting
NCT04931342Phase 2

A Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors

Active Not Recruiting
NCT03178552Phase 2

A Study to Evaluate the Efficacy and Safety of Multiple Targeted Therapies as Treatments for Participants With Non-Small Cell Lung Cancer (NSCLC)

Active Not Recruiting
NCT05691504Phase 1

Testing the Combination of APG-1252 (Pelcitoclax) and Cobimetinib in Recurrent Ovarian and Endometrial Cancers

Active Not Recruiting
NCT03337698Phase 1

A Study Of Multiple Immunotherapy-Based Treatment Combinations In Participants With Metastatic Non-Small Cell Lung Cancer (Morpheus- Non-Small Cell Lung Cancer)

Terminated
NCT03202940Phase 1

A Phase IB/II Study of Alectinib Combined With Cobimetinib in Advanced ALK-Rearranged (ALK+) NSCLC

Active Not Recruiting
NCT05441514Phase 1

Enasidenib in Combination With Cobimetinib for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

Completed
NCT03554083Phase 2

Vemurafenib, Cobimetinib, Atezolizumab, and Tiragolumab in Treating Patients With High-Risk Stage III Melanoma

Completed
NCT04216953Phase 1

MEK Inhibitor and a PDL1 Inhibitor Patients With Locally Advanced and/or Metastatic Soft Tissue Sarcoma

Completed
NCT07449754Phase 2

Belvarafenib in Combination With Cobimetinib in Patients With Locally Advanced or Metastatic NRAS-Mutant Melanoma

Recruiting
NCT02721459Phase 1

XL888 + Vemurafenib + Cobimetinib for Unresectable BRAF Mutated Stage III/IV Melanoma

Active Not Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
95