Success Metrics

Clinical Success Rate
76.6%

Based on 49 completed trials

Completion Rate
77%(49/64)
Active Trials
23(24%)
Results Posted
80%(39 trials)
Terminated
15(16%)

Phase Distribution

Ph phase_3
7
7%
Ph early_phase_1
2
2%
Ph not_applicable
1
1%
Ph phase_1
40
42%
Ph phase_2
43
45%

Phase Distribution

42

Early Stage

43

Mid Stage

7

Late Stage

Phase Distribution93 total trials
Early Phase 1First-in-human
2(2.2%)
Phase 1Safety & dosage
40(43.0%)
Phase 2Efficacy & side effects
43(46.2%)
Phase 3Large-scale testing
7(7.5%)
N/ANon-phased studies
1(1.1%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

72.1%

49 of 68 finished

Non-Completion Rate

27.9%

19 ended early

Currently Active

23

trials recruiting

Total Trials

95

all time

Status Distribution
Active(24)
Completed(49)
Terminated(19)
Other(3)

Detailed Status

Completed49
Active, not recruiting16
Terminated15
Recruiting7
Withdrawn4
unknown3

Development Timeline

Analytics

Development Status

Total Trials
95
Active
23
Success Rate
76.6%
Most Advanced
Phase 3

Trials by Phase

Early Phase 12 (2.2%)
Phase 140 (43.0%)
Phase 243 (46.2%)
Phase 37 (7.5%)
N/A1 (1.1%)

Trials by Status

completed4952%
recruiting77%
active_not_recruiting1617%
unknown33%
withdrawn44%
terminated1516%
not_yet_recruiting11%

Recent Activity

Clinical Trials (95)

Showing 20 of 95 trialsScroll for more
NCT05441514Phase 1

Enasidenib in Combination With Cobimetinib for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

Completed
NCT03554083Phase 2

Vemurafenib, Cobimetinib, Atezolizumab, and Tiragolumab in Treating Patients With High-Risk Stage III Melanoma

Completed
NCT03768063Phase 3

A Study in Patients Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study

Active Not Recruiting
NCT04409639Phase 2

Cobimetinib in Newly Diagnosed or HMA-treated CMML Patients With RAS Pathway Mutations

Active Not Recruiting
NCT04216953Phase 1

MEK Inhibitor and a PDL1 Inhibitor Patients With Locally Advanced and/or Metastatic Soft Tissue Sarcoma

Completed
NCT03175432Phase 2

Bevacizumab and Atezolizumab With or Without Cobimetinib in Treating Patients With Untreated Melanoma Brain Metastases

Active Not Recruiting
NCT05691504Phase 1

Testing the Combination of APG-1252 (Pelcitoclax) and Cobimetinib in Recurrent Ovarian and Endometrial Cancers

Active Not Recruiting
NCT04835805Phase 1

A Study to Evaluate the Safety and Activity of Belvarafenib as a Single Agent and in Combination With Either Cobimetinib or Cobimetinib Plus Nivolumab in Patients With NRAS-mutant Advanced Melanoma.

Active Not Recruiting
NCT04931342Phase 2

A Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors

Active Not Recruiting
NCT03178552Phase 2

A Study to Evaluate the Efficacy and Safety of Multiple Targeted Therapies as Treatments for Participants With Non-Small Cell Lung Cancer (NSCLC)

Active Not Recruiting
NCT04302025Phase 2

A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)

Recruiting
NCT07449754Phase 2

Belvarafenib in Combination With Cobimetinib in Patients With Locally Advanced or Metastatic NRAS-Mutant Melanoma

Recruiting
NCT02721459Phase 1

XL888 + Vemurafenib + Cobimetinib for Unresectable BRAF Mutated Stage III/IV Melanoma

Active Not Recruiting
NCT04005690Early Phase 1

Targeted Pathway Inhibition in Patients With Pancreatic Cancer

Recruiting
NCT06440850Phase 2

Vemurafenib and Cobimetinib for the Treatment of Patients With High Risk Differentiated Thyroid Carcinoma With BRAFV600E Mutation

Recruiting
NCT04109456Phase 1

IN10018 Monotherapy and Combination Therapy for Metastatic Melanoma

Completed
NCT03181100Phase 2

Atezolizumab With Chemotherapy in Treating Patients With Anaplastic or Poorly Differentiated Thyroid Cancer

Active Not Recruiting
NCT03202316Phase 2

Atezolizumab, Cobimetinib, and Eribulin in Treating Patients With Chemotherapy Resistant Metastatic Inflammatory Breast Cancer

Active Not Recruiting
NCT03281369Phase 1

A Study of Multiple Immunotherapy-Based Treatment Combinations in Patients With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Cancer (G/GEJ) or Esophageal Cancer (Morpheus-Gastric and Esophageal Cancer)

Completed
NCT03337698Phase 1

A Study Of Multiple Immunotherapy-Based Treatment Combinations In Participants With Metastatic Non-Small Cell Lung Cancer (Morpheus- Non-Small Cell Lung Cancer)

Completed

Drug Details

Intervention Type
DRUG
Total Trials
95