Success Metrics

Clinical Success Rate
72.9%

Based on 86 completed trials

Completion Rate
73%(86/118)
Active Trials
13(9%)
Results Posted
83%(71 trials)
Terminated
32(23%)

Phase Distribution

Ph phase_3
4
3%
Ph not_applicable
1
1%
Ph phase_1
61
44%
Ph phase_2
71
51%

Phase Distribution

61

Early Stage

71

Mid Stage

4

Late Stage

Phase Distribution137 total trials
Phase 1Safety & dosage
61(44.5%)
Phase 2Efficacy & side effects
71(51.8%)
Phase 3Large-scale testing
4(2.9%)
N/ANon-phased studies
1(0.7%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

70.5%

86 of 122 finished

Non-Completion Rate

29.5%

36 ended early

Currently Active

13

trials recruiting

Total Trials

138

all time

Status Distribution
Active(14)
Completed(86)
Terminated(36)
Other(2)

Detailed Status

Completed86
Terminated32
Recruiting8
Active, not recruiting5
Withdrawn4
unknown2

Development Timeline

Analytics

Development Status

Total Trials
138
Active
13
Success Rate
72.9%
Most Advanced
Phase 3

Trials by Phase

Phase 161 (44.5%)
Phase 271 (51.8%)
Phase 34 (2.9%)
N/A1 (0.7%)

Trials by Status

active_not_recruiting54%
withdrawn43%
recruiting86%
completed8662%
not_yet_recruiting11%
terminated3223%
unknown21%

Recent Activity

Clinical Trials (138)

Showing 20 of 138 trialsScroll for more
NCT07566377Phase 2

Cord Blood Transplantation in Children and Young Adults With Blood Cancer

Recruiting
NCT02727803Phase 2

Personalized NK Cell Therapy in CBT

Recruiting
NCT02883049Phase 3

Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations

Active Not Recruiting
NCT01279096Phase 1

Safety of Clofarabine With Multiagent Chemotherapy in Childhood Acute Lymphoblastic Leukemia

Completed
NCT04644016Phase 2

Cord Blood Transplant in Children and Young Adults With Blood Cancers and Non-malignant Disorders

Recruiting
NCT02425904Phase 2

Study of Clofarabine in Patients With Recurrent or Refractory Langerhans Cell Histiocytosis and LCH-related Disorders

Active Not Recruiting
NCT03136146Phase 2

Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma, Burkitt Lymphoma/Leukemia, or Double-Hit Lymphoma/Leukemia

Recruiting
NCT05917405Phase 2

Study Comparing the Efficacy of 2 RIC Regimens (Clofarabine vs Fludarabine) in Adults With AML Eligible to Allo-SCT

Recruiting
NCT06252870Phase 2

Study Testing Two Conditioning Regimen With a Single Prophylaxis of GVHD by Cyclophosphamide and Methotrexate Post-transplant in Patients Eligible for Matched-donor Allograft Transplantation

Recruiting
NCT04994808Phase 2

Treosulfan-Based Versus Clofarabine-Based Conditioning Before Donor Hematopoietic Stem Cell Transplant for the Treatment of Myelodysplastic Syndromes or Acute Myeloid Leukemia

Active Not Recruiting
NCT03117751Phase 2

Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma

Active Not Recruiting
NCT01885689Phase 2

Clofarabine and Melphalan Before Donor Stem Cell Transplant in Treating Patients With Myelodysplasia, Acute Leukemia in Remission, or Chronic Myelomonocytic Leukemia

Active Not Recruiting
NCT07156435Phase 1

Vyxeos® With Clofarabine for Pediatric AML

Recruiting
NCT07034053Phase 1

Clofarabine Therapy in Locally Advanced or Metastatic Urothelial Carcinoma

Recruiting
NCT06986382Phase 1

Phase 1b/2a Trial of Allogeneic HSCT From an HLA-partially Matched Related or Unrelated Donor After TCRab+ T-cell/CD19+ B-cell Depletion for Patients With Monogenic and/or Early-onset Medically Refractory Crohn Disease

Not Yet Recruiting
NCT03615105Phase 2

Donor Stem Cell Transplantation Using α/β+ T-lymphocyte Depleted Grafts From HLA Mismatched Donors

Terminated
NCT01701986Phase 1

Gemcitabine Hydrochloride, Clofarabine, and Busulfan Before Donor Stem Cell Transplant in Treating Patients With Refractory B-Cell or T-Cell Non-Hodgkin Lymphoma or Hodgkin Lymphoma

Completed
NCT02085408Phase 3

Clofarabine or Daunorubicin Hydrochloride and Cytarabine Followed By Decitabine or Observation in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia

Completed
NCT01228331Phase 2

Clofarabine or High-Dose Cytarabine and Pegaspargase in Children with ALL

Completed
NCT05569512Phase 1

Uproleselan With Pre-Transplant Conditioning in Hematopoietic Stem Cell Transplantation for AML

Terminated

Drug Details

Intervention Type
DRUG
Total Trials
138