Success Metrics

Clinical Success Rate
92.9%

Based on 13 completed trials

Completion Rate
93%(13/14)
Active Trials
14(44%)
Results Posted
92%(12 trials)
Terminated
1(3%)

Phase Distribution

Ph phase_2
13
41%
Ph phase_1
12
38%
Ph not_applicable
5
16%
Ph phase_3
1
3%

Phase Distribution

12

Early Stage

13

Mid Stage

1

Late Stage

Phase Distribution31 total trials
Phase 1Safety & dosage
12(38.7%)
Phase 2Efficacy & side effects
13(41.9%)
Phase 3Large-scale testing
1(3.2%)
N/ANon-phased studies
5(16.1%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

86.7%

13 of 15 finished

Non-Completion Rate

13.3%

2 ended early

Currently Active

14

trials recruiting

Total Trials

32

all time

Status Distribution
Active(14)
Completed(13)
Terminated(2)
Other(3)

Detailed Status

Completed13
Active, not recruiting7
Recruiting7
unknown2
Suspended1
Terminated1

Development Timeline

Analytics

Development Status

Total Trials
32
Active
14
Success Rate
92.9%
Most Advanced
Phase 3

Trials by Phase

Phase 112 (38.7%)
Phase 213 (41.9%)
Phase 31 (3.2%)
N/A5 (16.1%)

Trials by Status

active_not_recruiting722%
completed1341%
suspended13%
unknown26%
terminated13%
withdrawn13%
recruiting722%

Recent Activity

Clinical Trials (32)

Showing 20 of 32 trialsScroll for more
NCT06158828Phase 1

Pilot Study of Memory-like Natural Killer (ML NK) Cells After TCRαβ T Cell Depleted Haploidentical Transplant in AML

Recruiting
NCT02600208Phase 2

Peripheral Blood Stem Cell Transplantation for Hematologic Malignancies With Alpha Beta TCell and B Cell Depletion Using the CliniMACS Device

Active Not Recruiting
NCT04523376Not Applicable

Pilot Study PBSCT With TCRab Depletion For Hemoglobinopathies

Completed
NCT01857934Phase 2

Therapy for Children With Advanced Stage Neuroblastoma

Completed
NCT04337515Not Applicable

A Feasibility Study Using CLINIMACS® for Alpha/Beta T-Cell Depletion in Stem Cell Transplant

Recruiting
NCT03849651Phase 2

TCRαβ-depleted Progenitor Cell Graft With Additional Memory T-cell DLI, Plus Selected Use of Blinatumomab, in Naive T-cell Depleted Haploidentical Donor Hematopoietc Cell Transplantation for Hematologic Malignancies

Active Not Recruiting
NCT05664126Phase 2

Haplo-identical Viral-Specific T-cells for Treatment of Cytomegalovirus and Adenovirus Infections After Hematopoietic Cell Transplantation

Recruiting
NCT01625351Phase 1

A Study of CD45RA+ Depleted Haploidentical Stem Cell Transplantation in Children With Relapsed or Refractory Solid Tumors and Lymphomas

Completed
NCT07052370Phase 1

TCRαβ-depleted Progenitor Cell Graft With Early Memory T-cell DLI, Plus Selected Use of Blinatumomab, in naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies

Recruiting
NCT04881240Phase 1

Study of CD19-directed Allogeneic Memory T-cell Therapy for Relapsed/Refractory CD19+ Leukemia

Recruiting
NCT03573700Phase 1

Evaluation of CD19-Specific CAR Engineered Autologous T-Cells for Treatment of Relapsed/Refractory CD19+ Acute Lymphoblastic Leukemia

Active Not Recruiting
NCT01512888Phase 1

Gene Transfer for X-Linked Severe Combined Immunodeficiency in Newly Diagnosed Infants

Suspended
NCT05236764Not Applicable

Haploidentical Hematopoietic Cell Transplantation Using TCR Alpha/Beta and CD19 Depletion

Active Not Recruiting
NCT02790515Phase 2

Provision of TCRγδ T Cells and Memory T Cells Plus Selected Use of Blinatumomab in Naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies Relapsed or Refractory Despite Prior Transplantation

Active Not Recruiting
NCT03047746Not Applicable

Unrelated And Partially Matched Related Donor PSCT w/ T Cell Receptor (TCR) αβ Depletion for Patients With BMF

Active Not Recruiting
NCT04558736Phase 2

Haploidentical HCT for Severe Aplastic Anemia

Recruiting
NCT03597594Phase 1

Haplocompatible Transplant Using TCRα/β Depletion Followed by CD45RA-Depleted Donor Lymphocyte Infusions for Severe Combined Immunodeficiency (SCID)

Active Not Recruiting
NCT06082947Not Applicable

αβT Cell/CD19+ B Cell Depletion for Alternative Donor Allogeneic Hematopoietic Cell Transplantation (HSCT)

Recruiting
NCT00579124Phase 2

CHP 834 Unrelated and Partially Matched Related Donor Peripheral Stem Cell Transportation for T and B Cell Depletion

Completed
NCT01596257Phase 2

Bulk Versus Fractionated Stem Cell Infusions in Patients With Hematologic Malignancies Undergoing Stem Cell Transplantation

Completed

Drug Details

Intervention Type
DEVICE
Total Trials
32