Success Metrics

Clinical Success Rate
90.5%

Based on 38 completed trials

Completion Rate
90%(38/42)
Active Trials
20(24%)
Results Posted
53%(20 trials)
Terminated
4(5%)

Phase Distribution

Ph phase_2
39
46%
Ph phase_4
5
6%
Ph phase_3
8
9%
Ph not_applicable
1
1%
Ph phase_1
27
32%

Phase Distribution

27

Early Stage

39

Mid Stage

13

Late Stage

Phase Distribution80 total trials
Phase 1Safety & dosage
27(33.8%)
Phase 2Efficacy & side effects
39(48.8%)
Phase 3Large-scale testing
8(10.0%)
Phase 4Post-market surveillance
5(6.3%)
N/ANon-phased studies
1(1.3%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

80.9%

38 of 47 finished

Non-Completion Rate

19.1%

9 ended early

Currently Active

20

trials recruiting

Total Trials

85

all time

Status Distribution
Active(24)
Completed(38)
Terminated(9)
Other(14)

Detailed Status

Completed38
Recruiting15
unknown14
Withdrawn5
Active, not recruiting5
Terminated4

Development Timeline

Analytics

Development Status

Total Trials
85
Active
20
Success Rate
90.5%
Most Advanced
Phase 4

Trials by Phase

Phase 127 (33.8%)
Phase 239 (48.8%)
Phase 38 (10.0%)
Phase 45 (6.3%)
N/A1 (1.3%)

Trials by Status

withdrawn56%
unknown1416%
not_yet_recruiting34%
active_not_recruiting56%
completed3845%
recruiting1518%
terminated45%
enrolling_by_invitation11%

Recent Activity

Clinical Trials (85)

Showing 20 of 85 trialsScroll for more
NCT06965114Phase 1

Testing the Combination of Anti-cancer Drugs, Tovorafenib Plus Rituximab, in Patients With Hairy Cell Leukemia

Recruiting
NCT03586609Phase 2

Venetoclax, Cladribine, Low Dose Cytarabine, and Azacitidine in Treating Patients With Previously Untreated Acute Myeloid Leukemia

Recruiting
NCT04797767Phase 1

Venetoclax and CLAG-M for the Treatment of Acute Myeloid Leukemia and High-Grade Myeloid Neoplasms

Recruiting
NCT06561360Phase 2

A Study of Vemurafenib and Obinutuzumab Compared to Cladribine and Rituximab in People With Hairy Cell Leukemia (HCL)

Recruiting
NCT02250937Phase 2

Venetoclax and Sequential Busulfan, Cladribine, and Fludarabine Phosphate Before Donor Stem Cell Transplant in Treating Patients With Acute Myelogenous Leukemia or Myelodysplastic Syndrome

Active Not Recruiting
NCT06504459Phase 2

Venetoclax in Combination With Cladribine and Cytarabine Alternating With Azacitidine Plus Venetoclax for the Treatment of Newly Diagnosed Monocytic AML and Active Signaling Mutated AML

Recruiting
NCT06021600Phase 1

A Phase 1, Open-Label, Sequential Cross-over, Bioavailability/Bioequivalence Study to Compare the Pharmacokinetics of Oral Cladribine With the Reference Listed Drug, Intravenous Cladribine

Terminated
NCT04375631Phase 1

CLAG-M or FLAG-Ida Chemotherapy and Reduced-Intensity Conditioning Donor Stem Cell Transplant for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Chronic Myelomonocytic Leukemia

Recruiting
NCT04708054Phase 2

Venetoclax to Improve Outcomes of Fractionated Busulfan Regimen in Patients With High-Risk AML and MDS

Recruiting
NCT01515527Phase 2

Cladribine Plus Low Dose Cytarabine (LDAC) Alternating With Decitabine in Patients With Acute Myeloid Leukemia (AML) or High-Risk Myelodysplastic Syndrome (MDS)

Recruiting
NCT03926624Phase 3

Trial of DFP-10917 vs Non-Intensive or Intensive Reinduction for AML Patients in 2nd/3rd/4th Salvage

Terminated
NCT07311746Phase 1

Phase Ib/II Trial of Cladribine/Ruxolitinib/Venetoclax in Patients With Relapsed/Refractory T-cell Prolymphocytic Leukemia

Not Yet Recruiting
NCT05365035Phase 2

A Phase II Study of Cladribine and Low Dose Cytarabine in Combination With Venetoclax, Alternating With Azacitidine and Venetoclax, in Patients With Higher-risk Myeloproliferative Chronic Myelomonocytic Leukemia or Higher-risk Myelodysplastic Syndromes With Excess Blasts

Recruiting
NCT00412594Phase 2

Cladribine and Rituximab in Treating Patients With Hairy Cell Leukemia

Recruiting
NCT06232655Phase 2

Cladribine Venetoclax in Monocytic AML

Recruiting
NCT04047641Phase 1

Cladribine, Idarubicin, Cytarabine, and Quizartinib in Treating Patients With Newly Diagnosed, Relapsed, or Refractory Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

Recruiting
NCT04178005Phase 4

Cladribine Tablets After Treatment With Natalizumab (CLADRINA)

Active Not Recruiting
NCT03589729Phase 2

Dexrazoxane Hydrochloride in Preventing Heart-Related Side Effects of Chemotherapy in Participants With Blood Cancers

Recruiting
NCT02115295Phase 2

Cladribine, Idarubicin, Cytarabine, and Venetoclax in Treating Patients With Acute Myeloid Leukemia, High-Risk Myelodysplastic Syndrome, or Blastic Phase Chronic Myeloid Leukemia

Recruiting
NCT04848974Phase 1

Uproleselan, Cladribine, and Low Dose Cytarabine for the Treatment of Patients With Treated Secondary Acute Myeloid Leukemia

Completed

Drug Details

Intervention Type
DRUG
Total Trials
85