Success Metrics

Clinical Success Rate
80.8%

Based on 21 completed trials

Completion Rate
81%(21/26)
Active Trials
5(12%)
Results Posted
90%(19 trials)
Terminated
5(12%)

Phase Distribution

Ph not_applicable
2
5%
Ph phase_3
27
64%
Ph phase_4
2
5%
Ph phase_1
2
5%
Ph phase_2
8
19%

Phase Distribution

2

Early Stage

8

Mid Stage

29

Late Stage

Phase Distribution41 total trials
Phase 1Safety & dosage
2(4.9%)
Phase 2Efficacy & side effects
8(19.5%)
Phase 3Large-scale testing
27(65.9%)
Phase 4Post-market surveillance
2(4.9%)
N/ANon-phased studies
2(4.9%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

80.8%

21 of 26 finished

Non-Completion Rate

19.2%

5 ended early

Currently Active

5

trials recruiting

Total Trials

42

all time

Status Distribution
Active(5)
Completed(21)
Terminated(5)
Other(11)

Detailed Status

Completed21
unknown11
Terminated5
Active, not recruiting4
Recruiting1

Development Timeline

Analytics

Development Status

Total Trials
42
Active
5
Success Rate
80.8%
Most Advanced
Phase 4

Trials by Phase

Phase 12 (4.9%)
Phase 28 (19.5%)
Phase 327 (65.9%)
Phase 42 (4.9%)
N/A2 (4.9%)

Trials by Status

completed2150%
recruiting12%
active_not_recruiting410%
terminated512%
unknown1126%

Recent Activity

Clinical Trials (42)

Showing 20 of 42 trialsScroll for more
NCT03462719Phase 3

A Study of the Combination of Ibrutinib Plus Venetoclax Versus Chlorambucil Plus Obinutuzumab for the First-line Treatment of Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

Active Not Recruiting
NCT04075292Phase 3

Study of Acalabrutinib Versus Chlorambucil Plus Rituximab in Adult Subjects With Previously Untreated Chronic Lymphocytic Leukemia

Active Not Recruiting
NCT01808599Phase 2

Phase II Study of Chlorambucil and Subcutaneous Rituximab in Patients With Extranodal MALT Lymphoma

Active Not Recruiting
NCT02242942Phase 3

Comparison of the Treatments of Obinutuzumab + Venetoclax Versus Obinutuzumab + Chlorambucil in Patients With Chronic Lymphocytic Leukemia

Completed
NCT02475681Phase 3

Acalabrutinib, Obinutuzumab and Chlorambucil in Treatment naïve CLL

Active Not Recruiting
NCT02612311Phase 3

Ublituximab + TGR-1202 Compared to Obinutuzumab + Chlorambucil in Participants With Untreated and Previously Treated Chronic Lymphocytic Leukemia

Terminated
NCT06319456Phase 3

A Global Study of Lisaftoclax (APG-2575) Combined With Acalabrutinib Versus Immunochemotherapy for Newly Diagnosed CLL/SLL.

Recruiting
NCT04578613Phase 3

ICP-022 Versus Chlorambucil Combined With Rituximab in the Treatment of Untreated CLL/SLL

Unknown
NCT02915224

A Study of Obinutuzumab Evaluating Efficacy, Safety and Cost of Disease Management in Participants With Chronic Lymphocytic Leukemia and Comorbidities

Completed
NCT02336048Phase 1

A Study Evaluating the Safety of Tocilizumab in Addition to Standard of Care Premedication Given Before Obinutuzumab + Chlorambucil in Participants With Untreated B-Cell Chronic Lymphocytic Leukemia (B-CLL) and Comorbidities

Terminated
NCT01088048Phase 1

Study to Investigate Idelalisib in Combination With Chemotherapeutic Agents, Immunomodulatory Agents and Anti-CD20 Monoclonal Antibody (mAb) in Participants With Relapsed or Refractory Indolent B-cell Non-Hodgkin's Lymphoma, Mantle Cell Lymphoma or Chronic Lymphocytic Leukemia

Completed
NCT02264574Phase 3

A Multi-Center Study of Ibrutinib in Combination With Obinutuzumab Versus Chlorambucil in Combination With Obinutuzumab in Patients With Treatment naïve Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL)

Completed
NCT01905943Phase 3

A Safety and Efficacy Study of Obinutuzumab Alone or in Combination With Chemotherapy in Participants With Chronic Lymphocytic Leukemia

Completed
NCT00910910Phase 3

Study Of The Effectiveness & Safety Of Lenalidomide Versus Chlorambucil As First Line Therapy For Elderly Patients With B-Cell CLL (The ORIGIN Trial)

Completed
NCT00262795Phase 3

Fludarabine or Chlorambucil as First-Line Therapy in Treating Older Patients With Previously Untreated Chronic Lymphocytic Leukemia

Completed
NCT01283386Phase 4

A Study to Compare Mabthera (Rituximab), Fludarabine and Cyclophosphamide to Mabthera and Chlorambucil in Participants With Chronic Lymphocytic Leukemia and Unfavorable Somatic Status

Terminated
NCT01980875Phase 3

Efficacy and Safety of Idelalisib in Combination With Obinutuzumab Compared to Chlorambucil in Combination With Obinutuzumab for Previously Untreated Chronic Lymphocytic Leukemia

Terminated
NCT02053610Phase 3

CLL11: A Study of Obinutuzumab (RO5072759 [GA101]) With Chlorambucil in Patients With Previously Untreated Chronic Lymphocytic Leukemia (Stage 2)

Completed
NCT01010061Phase 3

CLL11: A Study of Obinutuzumab (RO5072759 [GA101]) With Chlorambucil in Patients With Previously Untreated Chronic Lymphocytic Leukemia (Stage 1a)

Completed
NCT01998880Phase 3

CLL11: A Study of Rituximab With Chlorambucil or Chlorambucil Alone in Patients With Previously Untreated Chronic Lymphocytic Leukemia (Stage 1b)

Completed

Drug Details

Intervention Type
DRUG
Total Trials
42