Success Metrics

Clinical Success Rate
41.2%

Based on 7 completed trials

Completion Rate
41%(7/17)
Active Trials
7(23%)
Results Posted
171%(12 trials)
Terminated
10(33%)

Phase Distribution

Ph phase_1
7
23%
Ph phase_3
3
10%
Ph phase_2
16
53%

Phase Distribution

7

Early Stage

16

Mid Stage

3

Late Stage

Phase Distribution26 total trials
Phase 1Safety & dosage
7(26.9%)
Phase 2Efficacy & side effects
16(61.5%)
Phase 3Large-scale testing
3(11.5%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

36.8%

7 of 19 finished

Non-Completion Rate

63.2%

12 ended early

Currently Active

7

trials recruiting

Total Trials

30

all time

Status Distribution
Active(8)
Completed(7)
Terminated(12)
Other(3)

Detailed Status

Terminated10
Completed7
Recruiting5
Active, not recruiting2
unknown2
Withdrawn2

Development Timeline

Analytics

Development Status

Total Trials
30
Active
7
Success Rate
41.2%
Most Advanced
Phase 3

Trials by Phase

Phase 17 (26.9%)
Phase 216 (61.5%)
Phase 33 (11.5%)

Trials by Status

active_not_recruiting27%
completed723%
suspended13%
unknown27%
not_yet_recruiting13%
terminated1033%
withdrawn27%
recruiting517%

Recent Activity

Clinical Trials (30)

Showing 20 of 30 trialsScroll for more
NCT05642572Phase 2

Comparing Combinations of Targeted Drugs for Advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes (A Lung-MAP Treatment Trial)

Recruiting
NCT03784014Phase 3

Molecular Profiling of Advanced Soft-tissue Sarcomas

Completed
NCT05488314Phase 1

A Study of Amivantamab and Capmatinib Combination Therapy in Unresectable Metastatic Non-small Cell Lung Cancer

Active Not Recruiting
NCT03040973Phase 2

Study to Allow Patients Previously Participating in a Novartis Sponsored Trial to Continue Receiving Capmatinib Treatment as Single Agent or in Combination With Other Treatments or the Combination Treatment Alone

Active Not Recruiting
NCT04677595Phase 2

Study of Capmatinib in Chinese Adult Patients With Advanced Non-small Cell Lung Cancer Harboring MET Exon 14 Skipping Mutation

Completed
NCT04741789

Managed Access Programs for INC280, Capmatinib

Unknown
NCT02813135Phase 1

European Proof-of-Concept Therapeutic Stratification Trial of Molecular Anomalies in Relapsed or Refractory Tumors

Recruiting
NCT05722886Phase 2

DETERMINE (Determining Extended Therapeutic Indications for Existing Drugs in Rare Molecularly Defined Indications Using a National Evaluation Platform Trial) - Master Screening Protocol

Recruiting
NCT06988475Phase 2

DETERMINE Trial Treatment Arm 06: Capmatinib in Adult Patients With Cancers Harbouring MET Dysregulations

Recruiting
NCT04926831Phase 2

Phase II of Neoadjuvant and Adjuvant Capmatinib in NSCLC

Terminated
NCT05243641Phase 1

Neratinib and Capmatinib Combination (Phase Ib/II) in Metastatic Breast Cancer and Inflammatory Breast Cancer Patients With Abnormal HER-family and c-Met Pathway Activity as Measured by the CELsignia Signaling Analysis Test

Terminated
NCT03742349Phase 1

Study of Safety and Efficacy of Novel Immunotherapy Combinations in Patients With Triple Negative Breast Cancer (TNBC).

Terminated
NCT04427072Phase 3

Study of Capmatinib Efficacy in Comparison With Docetaxel in Previously Treated Participants With Non-small Cell Lung Cancer Harboring MET Exon 14 Skipping Mutation

Terminated
NCT05703516

A Post Approval Commitment Study on Tabrecta® (Capmatinib) in South Korea

Recruiting
NCT04139317Phase 2

Safety and Efficacy of Capmatinib (INC280) Plus Pembrolizumab vs Pembrolizumab Alone in NSCLC With PD-L1≥ 50%

Terminated
NCT04323436Phase 2

Study of Capmatinib and Spartalizumab/Placebo in Advanced NSCLC Patients With MET Exon 14 Skipping Mutations

Terminated
NCT05567055Phase 2

Central Nervous System Efficacy of Capmatinib in NSCLC With Brain Metastases With cfDNA Positive MET Alterations

Withdrawn
NCT05435846Phase 1

Capmatinib Plus Trametinib for the Treatment of Metastatic Non-small Cell Lung Cancer With MET Exon 14 Skipping Mutation

Terminated
NCT02414139Phase 2

Study of Oral cMET Inhibitor INC280 in Patients With EGFR Wild-type (wt), Advanced Non-small Cell Lung Cancer (NSCLC) (Geometry Mono-1)

Completed
NCT04816214Phase 3

Study Evaluating Efficacy and Safety of Capmatinib in Combination With Osimertinib in Adult Subjects With Non-small Cell Lung Cancers as Second Line Therapy

Terminated

Drug Details

Intervention Type
DRUG
Total Trials
30