Success Metrics

Clinical Success Rate
100.0%

Based on 5 completed trials

Completion Rate
100%(5/5)
Active Trials
8(62%)
Results Posted
0%(0 trials)

Phase Distribution

Ph phase_2
1
8%
Ph phase_1
7
54%
Ph phase_3
5
38%

Phase Distribution

7

Early Stage

1

Mid Stage

5

Late Stage

Phase Distribution13 total trials
Phase 1Safety & dosage
7(53.8%)
Phase 2Efficacy & side effects
1(7.7%)
Phase 3Large-scale testing
5(38.5%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

100.0%

5 of 5 finished

Non-Completion Rate

0.0%

0 ended early

Currently Active

8

trials recruiting

Total Trials

13

all time

Status Distribution
Active(8)
Completed(5)

Detailed Status

Recruiting8
Completed5

Development Timeline

Analytics

Development Status

Total Trials
13
Active
8
Success Rate
100.0%
Most Advanced
Phase 3

Trials by Phase

Phase 17 (53.8%)
Phase 21 (7.7%)
Phase 35 (38.5%)

Trials by Status

recruiting862%
completed538%

Recent Activity

Clinical Trials (13)

Showing 13 of 13 trials
NCT07190248Phase 3

A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)

Recruiting
NCT07431827Phase 3

MK-3475A±Calderasib (MK-1084) in Completely Resected Stage IIA-IIIB (N2) KRAS G12Cm NSCLC (MK-1084-013)

Recruiting
NCT07209111Phase 2

A Clinical Study of Calderasib (MK-1084) in People With Advanced Solid Tumors (MK-1084-014)

Recruiting
NCT06997497Phase 3

A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)

Recruiting
NCT06345729Phase 3

A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004)

Recruiting
NCT07554339Phase 3

A Clinical Trial of Calderasib (MK-1084) and Durvalumab in People With Non-Small Cell Lung Cancer (MK-1084-015/KANDLELIT-015)

Recruiting
NCT05067283Phase 1

A Study of Calderasib (MK-1084) in KRAS Mutant Advanced Solid Tumors (MK-1084-001)

Recruiting
NCT07222098Phase 1

A Clinical Study of Calderasib (MK-1084) With Rosuvastatin and Metformin in Healthy People (MK-1084-016)

Completed
NCT07219550Phase 1

A Study of Calderasib (MK-1084) in Participants With Hepatic Impairment and Healthy Volunteers (MK-1084-017)

Recruiting
NCT06814119Phase 1

A Clinical Study of Calderasib (MK-1084) in Participants With Renal Impairment (MK-1084-010)

Completed
NCT06719557Phase 1

A Study of the Effect of Itraconazole and Phenytoin on Calderasib (MK-1084) in Healthy Adults (MK-1084-008)

Completed
NCT06575933Phase 1

A Study of Calderasib (MK-1084) With Midazolam and Digoxin in Healthy Participants (MK-1084-009)

Completed
NCT06619314Phase 1

A Study to Evaluate the Effect of Food, Formulation, and a Proton Pump Inhibitor (PPI) on Calderasib (MK-1084) in Healthy Adult Participants (MK-1084-003)

Completed

All 13 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
13