Success Metrics

Clinical Success Rate
60.0%

Based on 9 completed trials

Completion Rate
60%(9/15)
Active Trials
0(0%)
Results Posted
78%(7 trials)
Terminated
6(35%)

Phase Distribution

Ph phase_1
9
53%
Ph early_phase_1
1
6%
Ph phase_2
7
41%

Phase Distribution

10

Early Stage

7

Mid Stage

0

Late Stage

Phase Distribution17 total trials
Early Phase 1First-in-human
1(5.9%)
Phase 1Safety & dosage
9(52.9%)
Phase 2Efficacy & side effects
7(41.2%)

Highest Phase Reached

Phase 2

Trial Status & Enrollment

Completion Rate

56.3%

9 of 16 finished

Non-Completion Rate

43.8%

7 ended early

Currently Active

0

trials recruiting

Total Trials

17

all time

Status Distribution
Completed(9)
Terminated(7)
Other(1)

Detailed Status

Completed9
Terminated6
Withdrawn1
unknown1

Development Timeline

Analytics

Development Status

Total Trials
17
Active
0
Success Rate
60.0%
Most Advanced
Phase 2

Trials by Phase

Early Phase 11 (5.9%)
Phase 19 (52.9%)
Phase 27 (41.2%)

Trials by Status

withdrawn16%
terminated635%
unknown16%
completed953%

Recent Activity

Clinical Trials (17)

Showing 17 of 17 trials
NCT02340780Phase 2

Buparlisib in Patients With Relapsed and Refractory Chronic Lymphocytic Leukemia

Completed
NCT01971489Phase 1

Buparlisib, Gemcitabine Hydrochloride, and Cisplatin in Treating Patients With Advanced Solid Tumors

Withdrawn
NCT02756247Phase 1

A Clinical Trial of Buparlisib and Ibrutinib in Lymphoma

Completed
NCT01551030Phase 2

Buparlisib in Metastatic Transitional Cell Carcinoma of the Urothelium

Completed
NCT02154776Phase 1

Dose Escalation Study of LEE011 in Combination With Buparlisib and Letrozole in HR+, HER2-negative Post-menopausal Women With Advanced Breast Cancer.

Completed
NCT01934361Phase 1

Phase Ib/II Study of Buparlisib Plus Carboplatin or Lomustine in Patients With Recurrent Glioblastoma Multiforme

Completed
NCT02048787Phase 1

Pharmacokinetic Study of Buparlisib in Subjects With Renal Impairment.

Completed
NCT02614508Phase 1

Buparlisib and Ofatumumab or Ibrutinib in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia

Terminated
NCT02303041Phase 2

Pilot Study of Sonidegib and Buparlisib in Treating Patients With Advanced or Metastatic Basal Cell Carcinoma

Terminated
NCT01820325Phase 1

Safety and Efficacy of Buparlisib (BKM120) in Patients With Untreated Squamous Non-small Cell Lung Cancer

Terminated
NCT01719250Early Phase 1

Buparlisib in Treating Patients With Relapsed or Refractory Non-Hodgkin Lymphoma

Completed
NCT01693614Phase 2

Safety and Efficacy of BKM120 in Relapsed and Refractory NHL

Completed
NCT01923168Phase 2

Study of Letrozole With or Without BYL719 or Buparlisib, for the Neoadjuvant Treatment of Postmenopausal Women

Completed
NCT01911325Phase 1

Phase II Study of Buparlisib + Docetaxel in Advanced or Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) Patients

Terminated
NCT01852292Phase 2

Study of Efficacy and Safety of Buparlisib (BKM120) Plus Paclitaxel Versus Placebo Plus Paclitaxel in Recurrent or Metastatic Head and Neck Cancer Previously Pre-treated With a Platinum Therapy

Terminated
NCT01870726Phase 1

Safety and Efficacy of INC280 and Buparlisib (BKM120) in Patients With Recurrent Glioblastoma

Terminated
NCT02452294Phase 2

Buparlisib in Melanoma Patients Suffering From Brain Metastases (BUMPER)

Unknown

All 17 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
17