Success Metrics

Clinical Success Rate
70.6%

Based on 12 completed trials

Completion Rate
71%(12/17)
Active Trials
3(12%)
Results Posted
92%(11 trials)
Terminated
5(20%)

Phase Distribution

Ph phase_1
4
16%
Ph phase_3
2
8%
Ph early_phase_1
3
12%
Ph phase_4
8
32%
Ph phase_2
5
20%

Phase Distribution

7

Early Stage

5

Mid Stage

10

Late Stage

Phase Distribution22 total trials
Early Phase 1First-in-human
3(13.6%)
Phase 1Safety & dosage
4(18.2%)
Phase 2Efficacy & side effects
5(22.7%)
Phase 3Large-scale testing
2(9.1%)
Phase 4Post-market surveillance
8(36.4%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

66.7%

12 of 18 finished

Non-Completion Rate

33.3%

6 ended early

Currently Active

3

trials recruiting

Total Trials

25

all time

Status Distribution
Active(4)
Completed(12)
Terminated(6)
Other(3)

Detailed Status

Completed12
Terminated5
unknown3
Active, not recruiting2
Recruiting1
Enrolling by invitation1

Development Timeline

Analytics

Development Status

Total Trials
25
Active
3
Success Rate
70.6%
Most Advanced
Phase 4

Trials by Phase

Early Phase 13 (13.6%)
Phase 14 (18.2%)
Phase 25 (22.7%)
Phase 32 (9.1%)
Phase 48 (36.4%)

Trials by Status

recruiting14%
terminated520%
active_not_recruiting28%
completed1248%
enrolling_by_invitation14%
unknown312%
withdrawn14%

Recent Activity

Clinical Trials (25)

Showing 20 of 25 trialsScroll for more
NCT04306315Phase 4

Adjusted Brodalumab Dose Compared With Standard Brodalumab Dose in Subjects With Moderate-to-severe Plaque Psoriasis and ≥120 kg Body Weight

Completed
NCT04340076Phase 4

Dose Reduction of IL17 and IL23 Inhibitors in Psoriasis

Completed
NCT05132231

Canadian Real World Evidence Study of Brodalumab in Plaque Psoriasis to Understand the Impact on Quality of Life and Work Productivity

Active Not Recruiting
NCT03254667

LTS of Siliq vs. Other Therapies Treating of Adults With Moderate-to-Severe Psoriasis

Enrolling By Invitation
NCT03240809Phase 4

An Open-label, Single-dose Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Brodalumab in Pediatric Subjects

Active Not Recruiting
NCT06673329Phase 1

Brodalumab in the Treatment of Immune-Related Adverse Events

Recruiting
NCT04533737Phase 4

Efficacy and Safety of Brodalumab Compared With Guselkumab in the Treatment of Plaque Psoriasis After Inadequate Response to Ustekinumab

Terminated
NCT04305327Phase 3

Efficacy and Safety of Brodalumab in Adolescents From 12 to 17 Years of Age With Moderate-to-severe Plaque Psoriasis

Terminated
NCT03331835Phase 4

A Trial Comparing the Efficacy of Subcutaneous Injections of Brodalumab to Oral Administrations of Fumaric Acid Esters in Adults With Moderate to Severe Plaque Psoriasis

Completed
NCT02985983Phase 3

A Study of Brodalumab in Subjects With Axial Spondyloarthritis (axSpA)

Completed
NCT01902290Phase 2

Study of Efficacy and Safety of Brodalumab Compared With Placebo in Adults With Inadequately Controlled Asthma With High Bronchodilator Reversibility

Terminated
NCT04979520Early Phase 1

Molecular Characteristics of Brodalumab in Hidradenitis Suppurativa

Completed
NCT04149587

A Study of Brodalumab (SILIQ®) in Psoriasis Participants With Inadequate Response to Their Current Biologic Agent Regimen

Completed
NCT01150890Phase 2

Brodalumab (AMG 827) in Adults With Moderate to Severe Crohn's Disease

Terminated
NCT01199302Phase 2

Long-term Safety Study of Brodalumab in Adults With Crohn's Disease

Terminated
NCT00950989Phase 2

Brodalumab (AMG 827) in Rheumatoid Arthritis (RA) Participants With Inadequate Response to Methotrexate

Completed
NCT00771030Phase 1

Study to Evaluate the Safety, PK, PD and Efficacy of AMG 827 in Adults With Rheumatoid Arthritis

Completed
NCT03403036Phase 4

Brodalumab in Subjects With Moderate to Severe Plaque Psoriasis Who Have Failed IL-17A Therapies

Completed
NCT04622033Phase 4

Brodalumab in Palmoplantar Psoriasis

Unknown
NCT04249713Early Phase 1

An Alternative Dose Interval Study in Participants With Hidradenitis Suppurativa Receiving Brodalumab

Withdrawn

Drug Details

Intervention Type
BIOLOGICAL
Total Trials
25