Success Metrics

Clinical Success Rate
56.4%

Based on 22 completed trials

Completion Rate
56%(22/39)
Active Trials
27(38%)
Results Posted
114%(25 trials)
Terminated
17(24%)

Phase Distribution

Ph phase_1
29
40%
Ph not_applicable
1
1%
Ph phase_2
35
49%
Ph early_phase_1
2
3%
Ph phase_3
3
4%

Phase Distribution

31

Early Stage

35

Mid Stage

3

Late Stage

Phase Distribution70 total trials
Early Phase 1First-in-human
2(2.9%)
Phase 1Safety & dosage
29(41.4%)
Phase 2Efficacy & side effects
35(50.0%)
Phase 3Large-scale testing
3(4.3%)
N/ANon-phased studies
1(1.4%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

51.2%

22 of 43 finished

Non-Completion Rate

48.8%

21 ended early

Currently Active

27

trials recruiting

Total Trials

72

all time

Status Distribution
Active(27)
Completed(22)
Terminated(21)
Other(2)

Detailed Status

Completed22
Terminated17
Active, not recruiting15
Recruiting12
Withdrawn4
unknown2

Development Timeline

Analytics

Development Status

Total Trials
72
Active
27
Success Rate
56.4%
Most Advanced
Phase 3

Trials by Phase

Early Phase 12 (2.9%)
Phase 129 (41.4%)
Phase 235 (50.0%)
Phase 33 (4.3%)
N/A1 (1.4%)

Trials by Status

recruiting1217%
active_not_recruiting1521%
completed2231%
unknown23%
terminated1724%
withdrawn46%

Recent Activity

Clinical Trials (72)

Showing 20 of 72 trialsScroll for more
NCT05355701Phase 1

A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.

Recruiting
NCT05554367Phase 2

Palbociclib and Binimetinib in RAS-Mutant Cancers, A ComboMATCH Treatment Trial

Active Not Recruiting
NCT02465060Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

Active Not Recruiting
NCT05564377Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

Recruiting
NCT05564403Phase 2

Study of Chemotherapy, With or Without Binimetinib in Advanced Biliary Tract Cancers in 2nd Line Setting (A ComboMATCH Treatment Trial)

Active Not Recruiting
NCT04322383Phase 2

Binimetinib for People With Relapsed/Refractory BRAF Wild Type Hairy Cell Leukemia and Variant

Recruiting
NCT05111561Phase 1

Testing the Combination of the Anticancer Drugs ZEN003694 and Binimetinib in Patients With Advanced/Metastatic or Unresectable Solid Tumors With RAS Alterations and Triple Negative Breast Cancer

Recruiting
NCT03693170Phase 2

Encorafenib, Binimetinib and Cetuximab in Subjects With Previously Untreated BRAF-mutant ColoRectal Cancer

Completed
NCT04221438Phase 2

Testing Treatment With Encorafenib and Binimetinib Before Surgery for Melanoma With Lymph Node Involvement

Terminated
NCT03991819Phase 1

Study of Binimetinib in Combination With Pembrolizumab in Advanced Non-Small Cell Lung Cancer

Active Not Recruiting
NCT04324112Phase 2

Encorafenib Plus Binimetinib for People With BRAF V600 Mutated Relapsed/Refractory HCL

Active Not Recruiting
NCT02910700Phase 2

Nivolumab With Trametinib and Dabrafenib, or Encorafenib and Binimetinib in Treating Patients With BRAF Mutated Metastatic or Unresectable Stage III-IV Melanoma

Active Not Recruiting
NCT03947385Phase 1

Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions

Recruiting
NCT03839342Phase 2

Binimetinib and Encorafenib for the Treatment of Advanced Solid Tumors With Non-V600E BRAF Mutations

Active Not Recruiting
NCT04800822Phase 1

PF-07284892 in Participants With Advanced Solid Tumors

Terminated
NCT04598009Phase 2

Binimetinib and Imatinib for Unresectable Stage III-IV KIT-Mutant Melanoma

Recruiting
NCT05615818Phase 3

Personalized Medicine for Advanced Biliary Cancer Patients

Recruiting
NCT04439344Phase 2

Testing Binimetinib as a Potential Targeted Treatment in Cancers With NRAS Genetic Changes (MATCH-Subprotocol Z1A)

Active Not Recruiting
NCT05195632Phase 2

Phase II Study Investigating the Combination of Encorafenib and Binimetinib in BRAF V600E Mutated Chinese Patients With Metastatic Non-Small Cell Lung Cancer

Active Not Recruiting
NCT03971409Phase 2

Avelumab With Binimetinib, Sacituzumab Govitecan, or Liposomal Doxorubicin in Treating Stage IV or Unresectable, Recurrent Triple Negative Breast Cancer

Active Not Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
72