Success Metrics

Clinical Success Rate
56.4%

Based on 22 completed trials

Completion Rate
56%(22/39)
Active Trials
28(38%)
Results Posted
114%(25 trials)
Terminated
17(23%)

Phase Distribution

Ph phase_1
29
40%
Ph phase_2
35
48%
Ph phase_3
3
4%
Ph early_phase_1
2
3%
Ph phase_4
1
1%
Ph not_applicable
1
1%

Phase Distribution

31

Early Stage

35

Mid Stage

4

Late Stage

Phase Distribution71 total trials
Early Phase 1First-in-human
2(2.8%)
Phase 1Safety & dosage
29(40.8%)
Phase 2Efficacy & side effects
35(49.3%)
Phase 3Large-scale testing
3(4.2%)
Phase 4Post-market surveillance
1(1.4%)
N/ANon-phased studies
1(1.4%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

51.2%

22 of 43 finished

Non-Completion Rate

48.8%

21 ended early

Currently Active

28

trials recruiting

Total Trials

73

all time

Status Distribution
Active(28)
Completed(22)
Terminated(21)
Other(2)

Detailed Status

Completed22
Terminated17
Active, not recruiting16
Recruiting12
Withdrawn4
unknown2

Development Timeline

Analytics

Development Status

Total Trials
73
Active
28
Success Rate
56.4%
Most Advanced
Phase 4

Trials by Phase

Early Phase 12 (2.8%)
Phase 129 (40.8%)
Phase 235 (49.3%)
Phase 33 (4.2%)
Phase 41 (1.4%)
N/A1 (1.4%)

Trials by Status

completed2230%
withdrawn45%
unknown23%
recruiting1216%
active_not_recruiting1622%
terminated1723%

Recent Activity

Clinical Trials (73)

Showing 20 of 73 trialsScroll for more
NCT05203172Phase 4

The FLOTILLA Study: Providing Continued Access to The Study Medicines Encorafenib and Binimetinib for Participants in Prior Clinical Trials

Recruiting
NCT05564377Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

Recruiting
NCT02465060Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

Active Not Recruiting
NCT04322383Phase 2

Binimetinib for People With Relapsed/Refractory BRAF Wild Type Hairy Cell Leukemia and Variant

Recruiting
NCT04511013Phase 2

A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases

Recruiting
NCT04657991Phase 3

A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma

Active Not Recruiting
NCT05355701Phase 1

A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.

Active Not Recruiting
NCT05554367Phase 2

Palbociclib and Binimetinib in RAS-Mutant Cancers, A ComboMATCH Treatment Trial

Active Not Recruiting
NCT04598009Phase 2

Binimetinib and Imatinib for Unresectable Stage III-IV KIT-Mutant Melanoma

Recruiting
NCT05111561Phase 1

Testing the Combination of the Anticancer Drugs ZEN003694 and Binimetinib in Patients With Advanced/Metastatic or Unresectable Solid Tumors With RAS Alterations and Triple Negative Breast Cancer

Recruiting
NCT04221438Phase 2

Testing Treatment With Encorafenib and Binimetinib Before Surgery for Melanoma With Lymph Node Involvement

Terminated
NCT05564403Phase 2

Study of Chemotherapy, With or Without Binimetinib in Advanced Biliary Tract Cancers in 2nd Line Setting (A ComboMATCH Treatment Trial)

Active Not Recruiting
NCT03693170Phase 2

Encorafenib, Binimetinib and Cetuximab in Subjects With Previously Untreated BRAF-mutant ColoRectal Cancer

Completed
NCT03991819Phase 1

Study of Binimetinib in Combination With Pembrolizumab in Advanced Non-Small Cell Lung Cancer

Active Not Recruiting
NCT04324112Phase 2

Encorafenib Plus Binimetinib for People With BRAF V600 Mutated Relapsed/Refractory HCL

Active Not Recruiting
NCT02910700Phase 2

Nivolumab With Trametinib and Dabrafenib, or Encorafenib and Binimetinib in Treating Patients With BRAF Mutated Metastatic or Unresectable Stage III-IV Melanoma

Active Not Recruiting
NCT03947385Phase 1

Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions

Recruiting
NCT03839342Phase 2

Binimetinib and Encorafenib for the Treatment of Advanced Solid Tumors With Non-V600E BRAF Mutations

Active Not Recruiting
NCT04800822Phase 1

PF-07284892 in Participants With Advanced Solid Tumors

Terminated
NCT05615818Phase 3

Personalized Medicine for Advanced Biliary Cancer Patients

Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
73