Success Metrics

Clinical Success Rate
100.0%

Based on 4 completed trials

Completion Rate
100%(4/4)
Active Trials
5(45%)
Results Posted
100%(4 trials)

Phase Distribution

Ph phase_4
1
9%
Ph phase_3
6
55%
Ph phase_2
3
27%

Phase Distribution

0

Early Stage

3

Mid Stage

7

Late Stage

Phase Distribution10 total trials
Phase 2Efficacy & side effects
3(30.0%)
Phase 3Large-scale testing
6(60.0%)
Phase 4Post-market surveillance
1(10.0%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

80.0%

4 of 5 finished

Non-Completion Rate

20.0%

1 ended early

Currently Active

5

trials recruiting

Total Trials

11

all time

Status Distribution
Active(6)
Completed(4)
Terminated(1)

Detailed Status

Completed4
Active, not recruiting3
Recruiting2
Enrolling by invitation1
Withdrawn1

Development Timeline

Analytics

Development Status

Total Trials
11
Active
5
Success Rate
100.0%
Most Advanced
Phase 4

Trials by Phase

Phase 23 (30.0%)
Phase 36 (60.0%)
Phase 41 (10.0%)

Trials by Status

completed436%
enrolling_by_invitation19%
withdrawn19%
active_not_recruiting327%
recruiting218%

Recent Activity

Clinical Trials (11)

Showing 11 of 11 trials
NCT07266831Phase 2

A Clinical Study of Islatravir and Ulonivirine for People With HIV-1 Who Have Not Been Treated Before (MK-8591B-062)

Recruiting
NCT07666386

Safety and Efficacy of B/F/TAF in Pregnancy

Enrolling By Invitation
NCT04233879Phase 3

Study of Doravirine/Islatravir (DOR/ISL 100 mg/0.75 mg) to Evaluate the Antiretroviral Activity, Safety, and Tolerability in Treatment-Naïve Participants With Human Immunodeficiency Virus Type 1 (HIV-1) Infection (MK-8591A-020)

Completed
NCT04223791Phase 3

Switch to Doravirine/Islatravir (DOR/ISL) in Human Immunodeficiency Virus 1 (HIV-1) Participants Treated With Bictegravir/Emtricitabine/Tenofovir Alafenamide (BIC/FTC/TAF) (MK-8591A-018)

Completed
NCT04564547Phase 2

Dose Ranging, Switch Study of Islatravir (MK-8591) and Ulonivirine (MK-8507) Once-Weekly in Virologically-Suppressed Adults With Human Immunodeficiency Virus Type 1 (HIV-1) [MK-8591-013]

Completed
NCT05630755Phase 3

A Switch to Doravirine/Islatravir (DOR/ISL) in Participants With Human Immunodeficiency Virus Type 1 (HIV-1) Who Are Virologically Suppressed on Bictegravir/Emtricitabine/Tenofovir Alafenamide (BIC/FTC/TAF) (MK-8591A-052)

Active Not Recruiting
NCT05705349Phase 3

DOR/ISL in HIV-1 Antiretroviral Treatment-naïve Participants (MK-8591A-053)

Active Not Recruiting
NCT06891066Phase 2

A Study of Islatravir (ISL) and Ulonivirine (ULO) Once Weekly (QW) in Virologically Suppressed Adults With Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8591B-060)

Active Not Recruiting
NCT07075146Phase 3

DOR/TDF/3TC COmpared With BIC/FTC/TAF in ART-Naïve People Living With HIV and Overweight or Obesity

Recruiting
NCT06177574Phase 4

Study of Bictegravir/Emtricitavine/Tenofovir Alafenamide in HIV-1 Infected naïve Patients Using Test and Treat Stategy Rapid-initiation Model of Care: BIC-NOW Clinical Trial (BIC-NOW)

Completed
NCT05457530Phase 3

Doravirine and Weight Gain in Antiretroviral Naive

Withdrawn

All 11 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
11