Success Metrics

Clinical Success Rate
83.3%

Based on 5 completed trials

Completion Rate
83%(5/6)
Active Trials
5(33%)
Results Posted
40%(2 trials)
Terminated
1(7%)

Phase Distribution

Ph phase_2
10
67%
Ph phase_1
5
33%

Phase Distribution

5

Early Stage

10

Mid Stage

0

Late Stage

Phase Distribution15 total trials
Phase 1Safety & dosage
5(33.3%)
Phase 2Efficacy & side effects
10(66.7%)

Highest Phase Reached

Phase 2

Trial Status & Enrollment

Completion Rate

83.3%

5 of 6 finished

Non-Completion Rate

16.7%

1 ended early

Currently Active

5

trials recruiting

Total Trials

15

all time

Status Distribution
Active(5)
Completed(5)
Terminated(1)
Other(4)

Detailed Status

Completed5
unknown4
Active, not recruiting3
Recruiting2
Terminated1

Development Timeline

Analytics

Development Status

Total Trials
15
Active
5
Success Rate
83.3%
Most Advanced
Phase 2

Trials by Phase

Phase 15 (33.3%)
Phase 210 (66.7%)

Trials by Status

active_not_recruiting320%
completed533%
recruiting213%
terminated17%
unknown427%

Recent Activity

Clinical Trials (15)

Showing 15 of 15 trials
NCT02664935Phase 2

National Lung Matrix Trial: Multi-drug Phase II Trial in Non-Small Cell Lung Cancer

Completed
NCT03462342Phase 2

Combination ATR and PARP Inhibitor (CAPRI) Trial With AZD6738 and Olaparib in Recurrent Ovarian Cancer

Completed
NCT03787680Phase 2

Targeting Resistant Prostate Cancer With ATR and PARP Inhibition (TRAP Trial)

Active Not Recruiting
NCT03770429Phase 1

AZD6738 for Patients With Progressive MDS or CMML

Active Not Recruiting
NCT03740893Phase 2

PHOENIX DDR/Anti-PD-L1 Trial: A Pre-surgical Window of Opportunity and Post-surgical Adjuvant Biomarker Study of DNA Damage Response Inhibition With or Without Anti-PD-L1 Immunotherapy in Patients With Neoadjuvant Treatment Resistant Residual Triple Negative Breast Cancer

Recruiting
NCT02223923Phase 1

Phase I Study to Assess Safety of AZD6738 Alone and in Combination With Radiotherapy in Patients With Solid Tumours

Unknown
NCT04298021Phase 2

DDR-Umbrella Study of DDR Targeting Agents in Advanced Biliary Tract Cancer

Active Not Recruiting
NCT04298008Phase 2

AZD6738 Plus Durvalumab in Biliary Tract Cancer

Recruiting
NCT02576444Phase 2

OLAParib COmbinations

Terminated
NCT03527147Phase 1

Platform Study for the Treatment of Relapsed or Refractory Aggressive Non-Hodgkin's Lymphoma (PRISM Study)

Completed
NCT03780608Phase 2

This Study is a Phase II Study of AZD6738 in Combination With Durvalumab in Patients With Solid Tumor (Cohort A (N=30): GC Who Have Failed Secondary Chemotherapy Treatments Regimen; Cohort B (B=30): Melanoma Patients Who Have Failed to IO)

Unknown
NCT02630199Phase 1

Study of AZD6738, DNA Damage Repair/Novel Anti-cancer Agent, in Combination With Paclitaxel, in Refractory Cancer

Completed
NCT03669601Phase 1

AZD6738 & Gemcitabine as Combination Therapy

Unknown
NCT03428607Phase 2

Study of AZD6738 and Olaparib Combination Therapy in Relapsed Small Cell Lung Cancer Patients [SUKSES-N2]

Completed
NCT03182634Phase 2

The UK Plasma Based Molecular Profiling of Advanced Breast Cancer to Inform Therapeutic CHoices (plasmaMATCH) Trial

Unknown

All 15 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
15