Success Metrics

Clinical Success Rate
84.6%

Based on 11 completed trials

Completion Rate
85%(11/13)
Active Trials
2(12%)
Results Posted
18%(2 trials)
Terminated
2(12%)

Phase Distribution

Ph phase_1
7
41%
Ph phase_2
10
59%

Phase Distribution

7

Early Stage

10

Mid Stage

0

Late Stage

Phase Distribution17 total trials
Phase 1Safety & dosage
7(41.2%)
Phase 2Efficacy & side effects
10(58.8%)

Highest Phase Reached

Phase 2

Trial Status & Enrollment

Completion Rate

84.6%

11 of 13 finished

Non-Completion Rate

15.4%

2 ended early

Currently Active

2

trials recruiting

Total Trials

17

all time

Status Distribution
Active(2)
Completed(11)
Terminated(2)
Other(2)

Detailed Status

Completed11
Active, not recruiting2
Terminated2
unknown2

Development Timeline

Analytics

Development Status

Total Trials
17
Active
2
Success Rate
84.6%
Most Advanced
Phase 2

Trials by Phase

Phase 17 (41.2%)
Phase 210 (58.8%)

Trials by Status

active_not_recruiting212%
terminated212%
completed1165%
unknown212%

Recent Activity

Clinical Trials (17)

Showing 17 of 17 trials
NCT02664935Phase 2

National Lung Matrix Trial: Multi-drug Phase II Trial in Non-Small Cell Lung Cancer

Completed
NCT01992952Phase 1

Fulvestrant +/- Akt Inhibition in Advanced Aromatase Inhibitor Resistant Breast Cancer

Active Not Recruiting
NCT01226316Phase 1

Safety, Tolerability & Potential Anti-cancer Activity of Increasing Doses of AZD5363 in Different Treatment Schedules

Completed
NCT02423603Phase 2

PAKT: AZD5363 in Combination With Paclitaxel in Triple-Negative Advanced or Metastatic Breast Cancer

Completed
NCT02299999Phase 2

SAFIR02_Breast - Efficacy of Genome Analysis as a Therapeutic Decision Tool for Patients With Metastatic Breast Cancer

Active Not Recruiting
NCT02338622Phase 1

Trial of Olaparib in Combination with AZD5363 (ComPAKT)

Completed
NCT02117167Phase 2

SAFIR02_Lung - Efficacy of Targeted Drugs Guided by Genomic Profiles in Metastatic NSCLC Patients

Completed
NCT03310541Phase 1

AZD5363 in Patients With Advanced Solid Tumors Harboring AKT Mutations

Completed
NCT02576444Phase 2

OLAParib COmbinations

Terminated
NCT02121639Phase 1

Open Label Phase I/Randomised,Double Blind Phase II Study in mCRPC of AZD5363 In Combination With DP Chemotherapy

Completed
NCT02451956Phase 2

Study of AZD5363 in Combination With Paclitaxel, in Advanced Gastric Adenocarcinoma Patients Harboring PIK3CA Mutation and/or PIK3CA Amplification as a Second-line Chemotherapy

Completed
NCT02449655Phase 2

Trial of AZD5363 Plus Paclitaxel /AZD2014 Plus Paclitaxel in Biomarker Negative (PIK3CA/MEK/RAS/TP53/MET) Gastric Adenocarcinoma Patients as Second-line Chemotherapy

Terminated
NCT03182634Phase 2

The UK Plasma Based Molecular Profiling of Advanced Breast Cancer to Inform Therapeutic CHoices (plasmaMATCH) Trial

Unknown
NCT02525068Phase 2

A Study of Enzalutamide in Combination With AZD5363 in Patients With mCRPC

Unknown
NCT02077569Phase 2

AKT Inhibitor in Oestrogen Positive Breast Cancer

Completed
NCT01895946Phase 1

Comparison of Two Formulations of AZD5363 and the Effect of Food on Pharmacokinetic Exposure, Safety and Tolerability

Completed
NCT01353781Phase 1

Open Label Phase 1 Study in Japan for Patient With Advanced Solid Malignancies

Completed

All 17 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
17