Success Metrics

Clinical Success Rate
76.5%

Based on 13 completed trials

Completion Rate
76%(13/17)
Active Trials
2(11%)
Results Posted
54%(7 trials)
Terminated
4(21%)

Phase Distribution

Ph phase_1
9
47%
Ph early_phase_1
1
5%
Ph phase_2
9
47%

Phase Distribution

10

Early Stage

9

Mid Stage

0

Late Stage

Phase Distribution19 total trials
Early Phase 1First-in-human
1(5.3%)
Phase 1Safety & dosage
9(47.4%)
Phase 2Efficacy & side effects
9(47.4%)

Highest Phase Reached

Phase 2

Trial Status & Enrollment

Completion Rate

76.5%

13 of 17 finished

Non-Completion Rate

23.5%

4 ended early

Currently Active

2

trials recruiting

Total Trials

19

all time

Status Distribution
Active(2)
Completed(13)
Terminated(4)

Detailed Status

Completed13
Terminated4
Active, not recruiting2

Development Timeline

Analytics

Development Status

Total Trials
19
Active
2
Success Rate
76.5%
Most Advanced
Phase 2

Trials by Phase

Early Phase 11 (5.3%)
Phase 19 (47.4%)
Phase 29 (47.4%)

Trials by Status

terminated421%
completed1368%
active_not_recruiting211%

Recent Activity

Clinical Trials (19)

Showing 19 of 19 trials
NCT02617277Phase 1

Safety, Tolerability and Pharmacokinetics of AZD1775 (Adavosertib) Plus MEDI4736 (Durvalumab) in Patients With Advanced Solid Tumours

Completed
NCT02513563Phase 2

AZD1775 Plus Carboplatin-Paclitaxel in Squamous Cell Lung Cancer

Completed
NCT03668340Phase 2

AZD1775 in Women With Recurrent or Persistent Uterine Serous Carcinoma or Uterine Carcinosarcoma

Active Not Recruiting
NCT02546661Phase 1

Open-Label, Randomised, Multi-Drug, Biomarker-Directed, Phase 1b Study in Pts w/ Muscle Invasive Bladder Cancer

Active Not Recruiting
NCT03028766Phase 1

WEE1 Inhibitor with Cisplatin and Radiotherapy: a Trial in Head and Neck Cancer

Completed
NCT02610075Phase 1

Phase Ib Study to Determine MTD of AZD1775 Monotherapy in Patients With Locally Advanced or Metastatic Solid Tumours.

Completed
NCT02194829Phase 1

Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Gemcitabine Hydrochloride With or Without WEE1 Inhibitor AZD1775 in Treating Patients With Previously Untreated Pancreatic Cancer That Is Metastatic or Cannot Be Removed by Surgery

Completed
NCT02576444Phase 2

OLAParib COmbinations

Terminated
NCT02448329Phase 2

Study of AZD1775 in Combination With Paclitaxel, in Advanced Gastric Adenocarcinoma Patients Harboring TP53 Mutation as a Second-line Chemotherapy

Completed
NCT03012477Phase 2

CISPLATIN + AZD-1775 In Breast Cancer

Completed
NCT02585973Phase 1

Dose-escalating AZD1775 + Concurrent Radiation + Cisplatin for Intermediate/High Risk HNSCC

Completed
NCT02593019Phase 2

Phase II, Single-arm Study of AZD1775 Monotherapy in Relapsed Small Cell Lung Cancer Patients

Completed
NCT02207010Early Phase 1

A Phase 0 Study of AZD1775 in Recurrent GBM Patients

Completed
NCT02906059Phase 1

Study of Irinotecan and AZD1775, a Selective Wee 1 Inhibitor, in RAS or BRAF Mutated, Second-line Metastatic Colorectal Cancer

Completed
NCT02511795Phase 1

AZD1775 Combined With Olaparib in Patients With Refractory Solid Tumors

Completed
NCT02341456Phase 1

Phase Ib Study AZD1775 in Combination With Carboplatin and Paclitaxel in Adult Asian Patients With Solid Tumours

Completed
NCT02688907Phase 2

Phase II, Single-arm Study of AZD1775 Monotherapy in Relapsed Small Cell Lung Cancer Patients With MYC Family Amplification or CDKN2A Mutation Combined With TP53 Mutation

Terminated
NCT02087241Phase 2

Ph II Trial of Carboplatin and Pemetrexed With or Without AZD1775 for Untreated Lung Cancer

Terminated
NCT02087176Phase 2

A Placebo Controlled Study Comparing AZD1775+ Docetaxel Versus Placebo+Docetaxel to Treat Lung Cancer

Terminated

All 19 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
19