Success Metrics

Clinical Success Rate
57.7%

Based on 75 completed trials

Completion Rate
58%(75/130)
Active Trials
50(22%)
Results Posted
113%(85 trials)
Terminated
55(24%)

Phase Distribution

Ph early_phase_1
5
2%
Ph not_applicable
1
0%
Ph phase_3
16
7%
Ph phase_2
101
44%
Ph phase_1
93
41%

Phase Distribution

98

Early Stage

101

Mid Stage

16

Late Stage

Phase Distribution216 total trials
Early Phase 1First-in-human
5(2.3%)
Phase 1Safety & dosage
93(43.1%)
Phase 2Efficacy & side effects
101(46.8%)
Phase 3Large-scale testing
16(7.4%)
N/ANon-phased studies
1(0.5%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

49.7%

75 of 151 finished

Non-Completion Rate

50.3%

76 ended early

Currently Active

50

trials recruiting

Total Trials

227

all time

Status Distribution
Active(51)
Completed(75)
Terminated(76)
Other(25)

Detailed Status

Completed75
Terminated55
Active, not recruiting37
unknown24
Withdrawn21
Recruiting13

Development Timeline

Analytics

Development Status

Total Trials
227
Active
50
Success Rate
57.7%
Most Advanced
Phase 3

Trials by Phase

Early Phase 15 (2.3%)
Phase 193 (43.1%)
Phase 2101 (46.8%)
Phase 316 (7.4%)
N/A1 (0.5%)

Trials by Status

active_not_recruiting3716%
unknown2411%
withdrawn219%
completed7533%
suspended10%
terminated5524%
enrolling_by_invitation10%
recruiting136%

Recent Activity

Clinical Trials (227)

Showing 20 of 227 trialsScroll for more
NCT04068194Phase 1

Testing the Combination of New Anti-cancer Drug Peposertib With Avelumab and Radiation Therapy for Advanced/Metastatic Solid Tumors and Hepatobiliary Malignancies

Active Not Recruiting
NCT05947500Phase 2

Testing the Combination of Two Anticancer Drugs M1774 (Tuvusertib) and Avelumab to Evaluate Their Safety and Effectiveness in Treating Merkel Cell Skin Cancer, MATRiX Trial

Active Not Recruiting
NCT05267626Phase 1

Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer

Recruiting
NCT05081180Phase 1

Study of Avelumab in Combination With Lenvatinib for Children With Primary CNS Tumors

Terminated
NCT02912572Phase 2

Avelumab in Patients With MSS, MSI-H and POLE-mutated Recurrent or Persistent Endometrial Cancer and of Avelumab/Talazoparib and Avelumab/Axitinib in Patients With MSS Recurrent or Persistent Endometrial Cancer

Active Not Recruiting
NCT03076554Phase 2

A Pilot Study to Investigate the Safety and Clinical Activity of Avelumab (MSB0010718C) in Thymoma and Thymic Carcinoma After Progression on Platinum-Based Chemotherapy

Active Not Recruiting
NCT03006848Phase 2

A Phase II Trial of Avelumab in Patients With Recurrent or Progressive Osteosarcoma

Completed
NCT03414658Phase 2

The AVIATOR Study: Trastuzumab and Vinorelbine With Avelumab OR Avelumab & Utomilumab in Advanced HER2+ Breast Cancer

Active Not Recruiting
NCT04360941Phase 1

PAveMenT: Palbociclib and Avelumab in Metastatic AR+ Triple Negative Breast Cancer

Recruiting
NCT03744793Phase 2

Pemetrexed and Avelumab in Treating Patients With MTAP-Deficient Metastatic Urothelial Cancer

Active Not Recruiting
NCT02813135Phase 1

European Proof-of-Concept Therapeutic Stratification Trial of Molecular Anomalies in Relapsed or Refractory Tumors

Recruiting
NCT03391479Phase 2

A Study of Avelumab in Penile Cancer Who Are Unfit for or Have Progressed After Platinum-Based Chemotherapy

Active Not Recruiting
NCT03815643Phase 3

Avelumab Program Rollover Study

Active Not Recruiting
NCT05327686Phase 2

Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial

Recruiting
NCT04071236Phase 1

Radiation Medication (Radium-223 Dichloride) Versus Radium-223 Dichloride Plus Radiation Enhancing Medication (M3814) Versus Radium-223 Dichloride Plus M3814 Plus Avelumab (a Type of Immunotherapy) for Advanced Prostate Cancer Not Responsive to Hormonal Therapy

Suspended
NCT05059522Phase 3

Continued Access Study for Participants Deriving Benefit in Pfizer-Sponsored Avelumab Parent Studies That Are Closing

Active Not Recruiting
NCT07110038Phase 2

DEPECA-1 - A Phase II Study to Evaluate a First-line Systemic Therapy With Enfortumab Vedotin Plus Avelumab for Advanced and Metastatic Penile Carcinoma

Recruiting
NCT03271372Phase 3

Adjuvant Avelumab in Merkel Cell Cancer

Active Not Recruiting
NCT05092958Phase 3

Testing the Addition of the Anti-cancer Drug, Cabozantinib, to the Usual Immunotherapy Treatment, Avelumab, in Patients With Metastatic Urothelial Cancer, MAIN-CAV Study

Active Not Recruiting
NCT04266912Phase 1

Avelumab and M6620 for the Treatment of DDR Deficient Metastatic or Unresectable Solid Tumors

Active Not Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
227