Success Metrics

Clinical Success Rate
57.8%

Based on 74 completed trials

Completion Rate
58%(74/128)
Active Trials
53(23%)
Results Posted
114%(84 trials)
Terminated
54(24%)

Phase Distribution

Ph phase_3
16
7%
Ph not_applicable
1
0%
Ph phase_1
93
41%
Ph early_phase_1
5
2%
Ph phase_2
101
44%

Phase Distribution

98

Early Stage

101

Mid Stage

16

Late Stage

Phase Distribution216 total trials
Early Phase 1First-in-human
5(2.3%)
Phase 1Safety & dosage
93(43.1%)
Phase 2Efficacy & side effects
101(46.8%)
Phase 3Large-scale testing
16(7.4%)
N/ANon-phased studies
1(0.5%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

49.7%

74 of 149 finished

Non-Completion Rate

50.3%

75 ended early

Currently Active

53

trials recruiting

Total Trials

227

all time

Status Distribution
Active(53)
Completed(74)
Terminated(75)
Other(25)

Detailed Status

Completed74
Terminated54
Active, not recruiting39
unknown25
Withdrawn21
Recruiting14

Development Timeline

Analytics

Development Status

Total Trials
227
Active
53
Success Rate
57.8%
Most Advanced
Phase 3

Trials by Phase

Early Phase 15 (2.3%)
Phase 193 (43.1%)
Phase 2101 (46.8%)
Phase 316 (7.4%)
N/A1 (0.5%)

Trials by Status

terminated5424%
recruiting146%
withdrawn219%
active_not_recruiting3917%
unknown2511%
completed7433%

Recent Activity

Clinical Trials (227)

Showing 20 of 227 trialsScroll for more
NCT06892860Phase 2

Comparing 3 vs 6 Cycles of Platinum-based Chemotherapy Prior to Maintenance Avelumab in Advanced Urothelial Cancer

Recruiting
NCT03217747Phase 1

Avelumab, Utomilumab, Anti-OX40 Antibody PF-04518600, and Radiation Therapy in Treating Patients With Advanced Malignancies

Active Not Recruiting
NCT05327686Phase 2

Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial

Recruiting
NCT05947500Phase 2

Testing the Combination of Two Anticancer Drugs M1774 (Tuvusertib) and Avelumab to Evaluate Their Safety and Effectiveness in Treating Merkel Cell Skin Cancer, MATRiX Trial

Active Not Recruiting
NCT05081180Phase 1

Study of Avelumab in Combination With Lenvatinib for Children With Primary CNS Tumors

Active Not Recruiting
NCT05092958Phase 3

Testing the Addition of the Anti-cancer Drug, Cabozantinib, to the Usual Immunotherapy Treatment, Avelumab, in Patients With Metastatic Urothelial Cancer, MAIN-CAV Study

Active Not Recruiting
NCT04902040Phase 1

Plinabulin in Combination With Radiation/Immunotherapy in Patients With Select Advanced Cancers After Progression on PD-1 or PD-L1 Targeted Antibodies

Terminated
NCT04071236Phase 1

Radiation Medication (Radium-223 Dichloride) Versus Radium-223 Dichloride Plus Radiation Enhancing Medication (M3814) Versus Radium-223 Dichloride Plus M3814 Plus Avelumab (a Type of Immunotherapy) for Advanced Prostate Cancer Not Responsive to Hormonal Therapy

Recruiting
NCT03076554Phase 2

A Pilot Study to Investigate the Safety and Clinical Activity of Avelumab (MSB0010718C) in Thymoma and Thymic Carcinoma After Progression on Platinum-Based Chemotherapy

Active Not Recruiting
NCT05327530Phase 2

A Study of the Safety and Efficacy of Various Combinations of Avelumab as Therapy in Locally Advanced or Metastatic Urothelial Carcinoma (JAVELIN Bladder Medley)

Active Not Recruiting
NCT06225596Phase 2

Study BT8009-230 in Participants With Locally Advanced or Metastatic Urothelial Cancer (Duravelo-2)

Active Not Recruiting
NCT03971409Phase 2

Avelumab With Binimetinib, Sacituzumab Govitecan, or Liposomal Doxorubicin in Treating Stage IV or Unresectable, Recurrent Triple Negative Breast Cancer

Active Not Recruiting
NCT07110038Phase 2

DEPECA-1 - A Phase II Study to Evaluate a First-line Systemic Therapy With Enfortumab Vedotin Plus Avelumab for Advanced and Metastatic Penile Carcinoma

Recruiting
NCT05059522Phase 3

Continued Access Study for Participants Deriving Benefit in Pfizer-Sponsored Avelumab Parent Studies That Are Closing

Active Not Recruiting
NCT04068194Phase 1

Testing the Combination of New Anti-cancer Drug Peposertib With Avelumab and Radiation Therapy for Advanced/Metastatic Solid Tumors and Hepatobiliary Malignancies

Active Not Recruiting
NCT03271372Phase 3

Adjuvant Avelumab in Merkel Cell Cancer

Active Not Recruiting
NCT04291885Phase 2

Immunotherapy Adjuvant Trial in Patients With Stage I-III Merkel Cell Carcinoma

Active Not Recruiting
NCT04841148Phase 2

Avelumab or Hydroxychloroquine With or Without Palbociclib to Eliminate Dormant Breast Cancer

Recruiting
NCT03964532Phase 1

TALAVE: Induction Talazoparib Followed by Combination of Talazoparib and Avelumab in Advanced Breast Cancer

Active Not Recruiting
NCT04822350

A NON-INTERVENTIONAL STUDY ON AVELUMAB USE IN PATIENTS WITH ADVANCED OR METASTATIC UROTHELIAL CARCINOMA

Completed

Drug Details

Intervention Type
DRUG
Total Trials
227