Success Metrics

Clinical Success Rate
100.0%

Based on 8 completed trials

Completion Rate
100%(8/8)
Active Trials
9(43%)
Results Posted
50%(4 trials)

Phase Distribution

Ph phase_2
8
38%
Ph phase_3
1
5%
Ph not_applicable
1
5%
Ph phase_1
5
24%
Ph phase_4
2
10%

Phase Distribution

5

Early Stage

8

Mid Stage

3

Late Stage

Phase Distribution17 total trials
Phase 1Safety & dosage
5(29.4%)
Phase 2Efficacy & side effects
8(47.1%)
Phase 3Large-scale testing
1(5.9%)
Phase 4Post-market surveillance
2(11.8%)
N/ANon-phased studies
1(5.9%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

100.0%

8 of 8 finished

Non-Completion Rate

0.0%

0 ended early

Currently Active

9

trials recruiting

Total Trials

21

all time

Status Distribution
Active(10)
Completed(8)
Other(3)

Detailed Status

Recruiting8
Completed8
unknown3
Active, not recruiting1
Not yet recruiting1

Development Timeline

Analytics

Development Status

Total Trials
21
Active
9
Success Rate
100.0%
Most Advanced
Phase 4

Trials by Phase

Phase 15 (29.4%)
Phase 28 (47.1%)
Phase 31 (5.9%)
Phase 42 (11.8%)
N/A1 (5.9%)

Trials by Status

unknown314%
active_not_recruiting15%
recruiting838%
not_yet_recruiting15%
completed838%

Recent Activity

Clinical Trials (21)

Showing 20 of 21 trialsScroll for more
NCT04116541Phase 2

A Study Evaluating the Activity of Anti-cancer Treatments Targeting Tumor Molecular Alterations/Characteristics in Advanced / Metastatic Tumors.

Recruiting
NCT03580655Phase 2

(PATHFINDER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, in Patients With Advanced Systemic Mastocytosis

Completed
NCT07255638

A Non-Interventional Study in Participants With Indolent Systemic Mastocytosis (ISM) in Germany

Recruiting
NCT06327685Phase 1

Avapritinib With Decitabine in Patients With SM-AHN

Recruiting
NCT04771520Phase 2

Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors

Recruiting
NCT05381753

Safety and Efficacy of Avapritinib in Chinese Patients With Gastrointestinal Stromal Tumor (GIST) in the Real World

Completed
NCT06748001Phase 4

Avapritinib Rollover Study

Recruiting
NCT04773782Phase 1

A Study of Avapritinib in Pediatric Patients With Solid Tumors Dependent on KIT or PDGFRA Signaling

Completed
NCT03731260Phase 2

(PIONEER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, Versus Placebo in Patients With Indolent Systemic Mastocytosis

Active Not Recruiting
NCT07131059Not Applicable

MRD-positive AML Clinical Study

Recruiting
NCT06765915Phase 2

Avapritinib Maintenance for AML With KIT Mutations

Not Yet Recruiting
NCT04908176Phase 1

A Drug-drug Interaction Study of Avapritinib and Midazolam

Completed
NCT04825574Phase 4

Study for Patients Previously Treated in Avapritinib Clinical Trials

Completed
NCT04714086

Expanded Access Program for Avapritinib

Unknown
NCT06221683Phase 2

Clinical Study of Induction Therapy Options Based on Molecular Subtyping and MRD in Children and Adolescents With AML

Recruiting
NCT06316960Phase 2

Safety and Efficacy of Avapritinib in Relapsed or Refractory Pediatric CBF-AML With KIT Mutation

Recruiting
NCT05821738Phase 2

Avapritinib in CBF-AML With KIT Mutations

Unknown
NCT02561988Phase 1

(EXPLORER) Study of BLU-285 in Patients With Advanced Systemic Mastocytosis (AdvSM) and Relapsed or Refractory Myeloid Malignancies

Completed
NCT03465722Phase 3

(VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST

Completed
NCT02508532Phase 1

(NAVIGATOR) Study of BLU-285 in Patients With Gastrointestinal Stromal Tumors (GIST) and Other Relapsed and Refractory Solid Tumors

Completed

Drug Details

Intervention Type
DRUG
Total Trials
21