Success Metrics

Clinical Success Rate
100.0%

Based on 13 completed trials

Completion Rate
100%(13/13)
Active Trials
2(13%)
Results Posted
0%(0 trials)

Phase Distribution

Ph phase_1
3
19%
Ph phase_4
1
6%
Ph not_applicable
3
19%
Ph phase_3
2
13%
Ph early_phase_1
2
13%
Ph phase_2
5
31%

Phase Distribution

5

Early Stage

5

Mid Stage

3

Late Stage

Phase Distribution16 total trials
Early Phase 1First-in-human
2(12.5%)
Phase 1Safety & dosage
3(18.8%)
Phase 2Efficacy & side effects
5(31.3%)
Phase 3Large-scale testing
2(12.5%)
Phase 4Post-market surveillance
1(6.3%)
N/ANon-phased studies
3(18.8%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

100.0%

13 of 13 finished

Non-Completion Rate

0.0%

0 ended early

Currently Active

2

trials recruiting

Total Trials

16

all time

Status Distribution
Active(3)
Completed(13)

Detailed Status

Completed13
Recruiting2
Not yet recruiting1

Development Timeline

Analytics

Development Status

Total Trials
16
Active
2
Success Rate
100.0%
Most Advanced
Phase 4

Trials by Phase

Early Phase 12 (12.5%)
Phase 13 (18.8%)
Phase 25 (31.3%)
Phase 32 (12.5%)
Phase 41 (6.3%)
N/A3 (18.8%)

Trials by Status

not_yet_recruiting16%
completed1381%
recruiting213%

Recent Activity

Clinical Trials (16)

Showing 16 of 16 trials
NCT03568994Early Phase 1

Atovaquone (Mepron®) Combined With Conventional Chemotherapy for de Novo Acute Myeloid Leukemia (AML)

Completed
NCT07357103Phase 4

Positioning Second-line Therapies for Pneumocystis Jirovecii Pneumonia (PCP Alternatives)

Not Yet Recruiting
NCT05998135Phase 2

Repurposing Atovaquone for the Treatment of Platinum-Resistant Ovarian Cancer

Recruiting
NCT06624371Phase 1

Atovaquone Combined With Radiation in Children With Malignant Brain Tumors

Recruiting
NCT00000802Phase 3

A Randomized, Comparative Study of Daily Dapsone and Daily Atovaquone for Prophylaxis Against PCP in HIV-Infected Patients Who Are Intolerant of Trimethoprim and/or Sulfonamides

Completed
NCT00000811Phase 2

A Study to Compare Different Drugs Used to Prevent Serious Bacterial Infections in HIV-Positive Children

Completed
NCT00000773Phase 1

Phase I Safety and Pharmacokinetics Study of Microparticulate Atovaquone (m-Atovaquone; 566C80) in HIV-Infected and Perinatally Exposed Infants and Children

Completed
NCT00000794Phase 2

Phase II Randomized Open-Label Trial of Atovaquone Plus Pyrimethamine and Atovaquone Plus Sulfadiazine for the Treatment of Acute Toxoplasmic Encephalitis

Completed
NCT02628080Early Phase 1

Atovaquone as Tumour HypOxia Modifier

Completed
NCT01858831Phase 1

Single Oral Dose Study of Atovaquone/Proguanil Hydrochloride Combination Tablets and Atovaquone Suspension

Completed
NCT00000655Phase 2

A Randomized, Double-Blind Study of 566C80 Versus Septra (Sulfamethoxazole/Trimethoprim) for the Treatment of Pneumocystis Carinii Pneumonia in AIDS Patients

Completed
NCT00001996Phase 2

A Phase II Open Randomized Comparison of 566C80 and Pentamidine Isethionate for the Treatment of Pneumocystis Carinii Pneumonia in AIDS Patients Who Are Intolerant of Trimethoprim / Sulfamethoxazole

Completed
NCT00001991Not Applicable

A Treatment IND for 566C80 Therapy of Pneumocystis Carinii Pneumonia

Completed
NCT00001990Not Applicable

An Open-Label, Uncontrolled Clinical Trial of Oral 566C80 for the Treatment of Patients With Severe PCP Who Are Intolerant and/or Unresponsive to Therapy With Trimethoprim/Sulfamethoxazole and Parenteral Pentamidine

Completed
NCT00002340Phase 3

A Comparison of Atovaquone and Pentamidine in the Prevention of Pneumocystis Carinii Pneumonia in HIV-Infected Patients Who Cannot Take TMP/SMX

Completed
NCT00001994Not Applicable

A Pilot Study of 566C80 for the Salvage Treatment of Toxoplasmic Encephalitis in Patients Infected With the Human Immunodeficiency Virus (HIV) Who Have Failed or Are Intolerant of Pyrimethamine-Sulfadiazine

Completed

All 16 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
16