Success Metrics

Clinical Success Rate
80.0%

Based on 4 completed trials

Completion Rate
80%(4/5)
Active Trials
11(55%)
Results Posted
25%(1 trials)
Terminated
1(5%)

Phase Distribution

Ph phase_3
1
5%
Ph phase_2
4
20%
Ph phase_1
15
75%

Phase Distribution

15

Early Stage

4

Mid Stage

1

Late Stage

Phase Distribution20 total trials
Phase 1Safety & dosage
15(75.0%)
Phase 2Efficacy & side effects
4(20.0%)
Phase 3Large-scale testing
1(5.0%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

50.0%

4 of 8 finished

Non-Completion Rate

50.0%

4 ended early

Currently Active

11

trials recruiting

Total Trials

20

all time

Status Distribution
Active(12)
Completed(4)
Terminated(4)

Detailed Status

Recruiting10
Completed4
Withdrawn3
Enrolling by invitation1
Terminated1
Active, not recruiting1

Development Timeline

Analytics

Development Status

Total Trials
20
Active
11
Success Rate
80.0%
Most Advanced
Phase 3

Trials by Phase

Phase 115 (75.0%)
Phase 24 (20.0%)
Phase 31 (5.0%)

Trials by Status

enrolling_by_invitation15%
terminated15%
active_not_recruiting15%
recruiting1050%
completed420%
withdrawn315%

Recent Activity

Clinical Trials (20)

Showing 20 of 20 trials
NCT04953910Phase 1

Study to Evaluate the Pharmacokinetics and Safety of Oral Decitabine and Cedazuridine in Cancer Patients With Hepatic Impairment

Recruiting
NCT04953897Phase 1

Study to Evaluate the Pharmacokinetics and Safety of Oral Decitabine and Cedazuridine in Cancer Patients With Renal Impairment

Recruiting
NCT06191978Phase 1

A Phase Ia/Ib Open-label, Multiple Dose, Study to Determine the Recommended Dose, Evaluate PKs, PDs, Safety, and Activity of Venetoclax in Combination With Oral Decitabine/Cedazuridine (ASTX727) in Pediatric Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML)

Recruiting
NCT04061421Phase 1

Active Myeloid Target Compound Combinations in MDS/MPN Overlap Syndromes Overlap Syndromes (ABNL-MARRO)

Recruiting
NCT03922555Phase 1

ASTX727 in Recurrent/Progressive Non-enhancing IDH Mutant Gliomas

Recruiting
NCT05360160Phase 1

A Phase I-II Study Investigating the All-Oral Combination of the Menin Inhibitor SNDX-5613 With Decitabine/Cedazuridine (ASTX727) and Venetoclax in Acute Myeloid Leukemia (SAVE)

Recruiting
NCT06297629Phase 2

A Phase I/II Trial to Assess the Efficacy and Toxicity of ASTX727 (Oral Decitabine/Cedazuridine) for the Treatment of Hematological Neoplasms After Allogeneic Stem Cell Transplantation

Withdrawn
NCT06284460Phase 1

Phase I/II Study of a Combination of Decitabine and Cedazuridine (ASTX727) and ASTX029, an ERK Inhibitor, for Patients With RAS Pathway Mutant Myelodysplastic Syndromes and Myelodysplastic/Myeloproliferative Neoplasms

Withdrawn
NCT04872543Phase 2

A Study of ASTX727 in People With Malignant Peripheral Nerve Sheath Tumors (MPNST)

Recruiting
NCT06177171Phase 1

Olaparib and ASTX727 in BRCA1/2- and Homologous Recombination Deficient (HRD)-Mutated Tumors

Recruiting
NCT05178693Phase 1

Lutathera and ASTX727 in Neuroendocrine Tumours

Recruiting
NCT04093570Phase 2

A Study for Participants Who Participated in Prior Clinical Studies of ASTX727 (Standard Dose)

Enrolling By Invitation
NCT02998567Phase 1

Combination Study of Guadecitabine/ASTX727 and Pembrolizumab

Recruiting
NCT04857645Phase 2

ASTX727 and Donor Lymphocyte Infusions After Allogenic Stem Cell Transplantation in Very High Risk MDS or AML Patients

Completed
NCT03906695Phase 1

Phase 1 Trial of ASTX727 in Subjects With Lower-risk Myelodysplastic Syndromes

Active Not Recruiting
NCT02649790Phase 1

Study of the Safety, Tolerability and Efficacy of KPT-8602 in Participants With Relapsed/Refractory Cancer Indications

Completed
NCT06113289Phase 1

A Phase 1B/2A Trial of Combination of ASTX727 With ASTX029 in Acute Myeloid Leukemia

Withdrawn
NCT03306264Phase 3

Study of ASTX727 vs IV Decitabine in Participants With MDS, CMML, and AML

Completed
NCT04155580Phase 1

A Study of ASTX660 as a Single Agent and in Combination With ASTX727 in Subjects With Relapsed/Refractory Acute Myeloid Leukemia (AML)

Terminated
NCT04134884Phase 1

Study of ASTX727 Plus Talazoparib in Patients With Triple Negative or Hormone Resistant/HER2-negative Metastatic Breast Cancer

Completed

All 20 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
20