Success Metrics

Clinical Success Rate
81.1%

Based on 30 completed trials

Completion Rate
81%(30/37)
Active Trials
3(7%)
Results Posted
80%(24 trials)
Terminated
7(16%)

Phase Distribution

Ph phase_2
12
27%
Ph not_applicable
7
16%
Ph phase_3
13
29%
Ph phase_1
4
9%
Ph phase_4
7
16%

Phase Distribution

4

Early Stage

12

Mid Stage

20

Late Stage

Phase Distribution43 total trials
Phase 1Safety & dosage
4(9.3%)
Phase 2Efficacy & side effects
12(27.9%)
Phase 3Large-scale testing
13(30.2%)
Phase 4Post-market surveillance
7(16.3%)
N/ANon-phased studies
7(16.3%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

78.9%

30 of 38 finished

Non-Completion Rate

21.1%

8 ended early

Currently Active

3

trials recruiting

Total Trials

45

all time

Status Distribution
Active(5)
Completed(30)
Terminated(8)
Other(2)

Detailed Status

Completed30
Terminated7
Not yet recruiting2
Recruiting2
unknown2
Withdrawn1

Development Timeline

Analytics

Development Status

Total Trials
45
Active
3
Success Rate
81.1%
Most Advanced
Phase 4

Trials by Phase

Phase 14 (9.3%)
Phase 212 (27.9%)
Phase 313 (30.2%)
Phase 47 (16.3%)
N/A7 (16.3%)

Trials by Status

not_yet_recruiting24%
withdrawn12%
recruiting24%
terminated716%
unknown24%
active_not_recruiting12%
completed3067%

Recent Activity

Clinical Trials (45)

Showing 20 of 45 trialsScroll for more
NCT06256432Phase 2

Endothelin Receptor Antagonism With Ambrisentan to Treat Hepatorenal Syndrome

Active Not Recruiting
NCT07245680Phase 3

COMMODITIES Trial: Initial Dual Oral Therapy vs Monotherapy in PAH With Cardiovascular Comorbidities

Not Yet Recruiting
NCT06968962Not Applicable

Comparison of Sequential to Initial Combination Therapy in PAH

Recruiting
NCT06987097Not Applicable

Ambrisentan for Early Low-Risk Pulmonary Arterial Hypertension

Not Yet Recruiting
NCT04393246Phase 2

mulTi-Arm Therapeutic Study in Pre-ICu Patients Admitted With Covid-19 - Experimental Drugs and Mechanisms

Completed
NCT04771000Phase 2

A Study of Micro Dose Ambrisentan in Hospitalized Patients With Respiratory Insufficiency Due to COVID-19

Terminated
NCT01342952Phase 2

Long-term Ambrisentan Extension Study for Pediatric Patients Who Participated in AMB112529

Completed
NCT04972656Not Applicable

Treatment With Ambrisentan in Patients With Borderline Pulmonary Arterial Hypertension

Recruiting
NCT05437224Phase 3

Efficacy and Safety Study of Ambrisentan in Chinese Patients With Pulmonary Arterial Hypertension

Completed
NCT01338636Phase 4

An Open-Label Uncontrolled Study of the Safety and Efficacy of Ambrisentan in Participants With Exercise-Induced Pulmonary Arterial Hypertension (PAH)

Completed
NCT03827200Phase 2

A Study Evaluating the Utility of Ambrisentan in Lowering Portal Pressure in Patients With Liver Cirrhosis

Terminated
NCT02169752Not Applicable

Ambrisentan for the Improvement in Right Ventricular Strain in Scleroderma Associated Pulmonary Arterial Hypertension

Terminated
NCT01224210Phase 3

Ambrisentan in Patients With Porto-pulmonary Hypertension A Multicenter Open Label Trial

Completed
NCT01051960Phase 4

Exercise Induced Pulmonary Hypertension in Systemic Sclerosis and Treatment With Ambrisentan

Completed
NCT00777920Phase 3

Study of Ambrisentan in Participants With Pulmonary Hypertension

Completed
NCT01406327

Drug Use Investigation for VOLIBRIS® (Ambrisentan) (Pulmonary Arterial Hypertension)

Completed
NCT04528056Phase 1

Pilot Study of the Safety and Efficacy of Sulfasalazine in Pulmonary Arterial Hypertension

Unknown
NCT00840463Phase 4

Safety and Efficacy Trial to Treat Diastolic Heart Failure Using Ambrisentan

Terminated
NCT02290613Phase 2

Early Treatment of Borderline Pulmonary Arterial Hypertension Associated With Systemic Sclerosis (SSc-APAH)

Completed
NCT02712346Phase 1

The Role of Endothelin-1 in Sickle Cell Disease

Completed

Drug Details

Intervention Type
DRUG
Total Trials
45