Success Metrics

Clinical Success Rate
95.5%

Based on 42 completed trials

Completion Rate
95%(42/44)
Active Trials
4(7%)
Results Posted
71%(30 trials)
Terminated
2(3%)

Phase Distribution

Ph phase_2
12
20%
Ph phase_4
10
17%
Ph not_applicable
1
2%
Ph phase_1
6
10%
Ph phase_3
26
44%
Ph early_phase_1
1
2%

Phase Distribution

7

Early Stage

12

Mid Stage

36

Late Stage

Phase Distribution56 total trials
Early Phase 1First-in-human
1(1.8%)
Phase 1Safety & dosage
6(10.7%)
Phase 2Efficacy & side effects
12(21.4%)
Phase 3Large-scale testing
26(46.4%)
Phase 4Post-market surveillance
10(17.9%)
N/ANon-phased studies
1(1.8%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

93.3%

42 of 45 finished

Non-Completion Rate

6.7%

3 ended early

Currently Active

4

trials recruiting

Total Trials

59

all time

Status Distribution
Active(6)
Completed(42)
Terminated(3)
Other(8)

Detailed Status

Completed42
unknown7
Recruiting3
Not yet recruiting2
Terminated2
Withdrawn1

Development Timeline

Analytics

Development Status

Total Trials
59
Active
4
Success Rate
95.5%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (1.8%)
Phase 16 (10.7%)
Phase 212 (21.4%)
Phase 326 (46.4%)
Phase 410 (17.9%)
N/A1 (1.8%)

Trials by Status

withdrawn12%
recruiting35%
completed4271%
not_yet_recruiting23%
terminated23%
active_not_recruiting12%
suspended12%
unknown712%

Recent Activity

Clinical Trials (59)

Showing 20 of 59 trialsScroll for more
NCT04781322Phase 1

Safety, Tolerability, and Bioeffects of Alirocumab in Non-treatment Seeking Heavy Drinkers

Recruiting
NCT03537742Phase 2

Cardiac Allograft Vasculopathy Inhibition With Alirocumab

Completed
NCT07477704Phase 2

A Study to See How Safe and Effective Alirocumab is When Given Weekly to Adult Participants Who Have Hypercholesterolemia

Not Yet Recruiting
NCT06385262Phase 2

TOP 2301: Neoadjuvant Chemo for NSCLC

Suspended
NCT05292404Phase 4

Impact of Early PCSK9 Inhibitor Treatment on Heart After Acute Myocardium Infarction

Recruiting
NCT03207945Phase 3

Effect of PCSK9 Inhibition on Cardiovascular Risk in Treated HIV Infection (EPIC-HIV Study)

Completed
NCT06858332

Lipoprotein(a) Levels in Patients With Atherosclerotic Cardiovascular Diseases in Russia

Recruiting
NCT05001984Phase 2

Trial of PCSK9 Inhibition in Patients with Acute Stroke and Symptomatic Intracranial Atherosclerosis

Active Not Recruiting
NCT05469347Phase 1

Alirocumab in Patients with Sepsis

Completed
NCT04189484Phase 1

Pharmacodynamic Biomarkers to Support Biosimilar Development: PCSK9 Inhibitors

Completed
NCT06080256Phase 3

Extra Alirocumab in Addition to Statin Therapy in Asymptomatic Intracranial Atherosclerotic Stenosis (EAST-aICAS)

Unknown
NCT06083961Phase 4

The Effect of Early Administration of PCSK9 Inhibitor to Acute Ischemic Stroke Patients Associated With Atherosclerosis on the Stroke Prognosis and Lipid Profile

Not Yet Recruiting
NCT04193306Phase 4

Efficacy and Safety Of Alirocumab to Prevent Early Cardiac Allograft Vasculopathy in Recent Heart Transplant Recipients

Unknown
NCT06052020

Extra Alirocumab in Addition to Statin Therapy in Symptomatic IntraCranial Atherosclerotic Stenosis ----a Pilot Study

Unknown
NCT02959047Phase 4

A Trial of Alirocumab and Plaque Regression in Peripheral Arterial Disease

Completed
NCT04790513Phase 3

Trial to Evaluate Efficacy and Safety of LIB003, Evolocumab and Alirocumab in High-risk CVD Patients

Completed
NCT03344692Phase 3

Effect of Alirocumab on Postprandial Hyperlipemia in Patients With Type 2 Diabetes

Completed
NCT03004001Phase 2

Effect of PCSK9-Antibody (Alirocumab) on Dyslipidemia Secondary to Nephrotic Syndrome

Terminated
NCT05465278Phase 4

Alirocumab and Plaque Burden In Familial Hypercholesterolaemia

Completed
NCT03718286Phase 2

Effects of Acute, Rapid Lowering of LDL Cholesterol With Alirocumab in Patients With STEMI Undergoing Primary PCI

Completed

Drug Details

Intervention Type
DRUG
Total Trials
59