Success Metrics

Clinical Success Rate
72.5%

Based on 95 completed trials

Completion Rate
73%(95/131)
Active Trials
31(17%)
Results Posted
77%(73 trials)
Terminated
36(20%)

Phase Distribution

Ph phase_1
48
26%
Ph not_applicable
7
4%
Ph early_phase_1
4
2%
Ph phase_2
99
54%
Ph phase_3
9
5%
Ph phase_4
11
6%

Phase Distribution

52

Early Stage

99

Mid Stage

20

Late Stage

Phase Distribution178 total trials
Early Phase 1First-in-human
4(2.2%)
Phase 1Safety & dosage
48(27.0%)
Phase 2Efficacy & side effects
99(55.6%)
Phase 3Large-scale testing
9(5.1%)
Phase 4Post-market surveillance
11(6.2%)
N/ANon-phased studies
7(3.9%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

70.9%

95 of 134 finished

Non-Completion Rate

29.1%

39 ended early

Currently Active

31

trials recruiting

Total Trials

184

all time

Status Distribution
Active(32)
Completed(95)
Terminated(39)
Other(18)

Detailed Status

Completed95
Terminated36
unknown17
Active, not recruiting16
Recruiting15
Withdrawn3

Development Timeline

Analytics

Development Status

Total Trials
184
Active
31
Success Rate
72.5%
Most Advanced
Phase 4

Trials by Phase

Early Phase 14 (2.2%)
Phase 148 (27.0%)
Phase 299 (55.6%)
Phase 39 (5.1%)
Phase 411 (6.2%)
N/A7 (3.9%)

Trials by Status

suspended11%
not_yet_recruiting11%
recruiting158%
completed9552%
unknown179%
active_not_recruiting169%
terminated3620%
withdrawn32%

Recent Activity

Clinical Trials (184)

Showing 20 of 184 trialsScroll for more
NCT02629120Phase 1

High Dose Peripheral Blood Stem Cell Transplantation With Post Transplant Cyclophosphamide for Patients With Chronic Granulomatous Disease

Active Not Recruiting
NCT03821610Phase 2

A Comparison of Reduced Dose Total Body Irradiation (TBI) and Cyclophosphamide With Fludarabine and Melphalan Reduced Intensity Conditioning in Adults With Acute Lymphoblastic Leukaemia (ALL) in Complete Remission. (ALL-RIC)

Active Not Recruiting
NCT05463133Phase 1

Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease (CGD) With an Alemtuzumab, Busulfan and TBI-based Conditioning Regimen Combined With Cytokine (IL-6, +/- IFN-gamma) Antagonists

Recruiting
NCT04339777Phase 2

Allogeneic Hematopoietic Stem Cell Transplant for Patients With Inborn Errors of Immunity

Recruiting
NCT03214354Phase 2

Nonmyeloablative Stem Cell Transplant in Children With Sickle Cell Disease and a Major ABO-Incompatible Matched Sibling Donor

Recruiting
NCT03910452Early Phase 1

Haploidentical Transplant for People With Chronic Granulomatous Disease (CGD) Using Alemtuzumab, Busulfan and TBI With Post-Transplant Cyclophosphamide

Active Not Recruiting
NCT03077542Phase 1

Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease

Active Not Recruiting
NCT00977691Phase 1

Haploidentical PBMC Transplant for Severe Congenital Anemias

Active Not Recruiting
NCT06084780Phase 2

Intestinal & Multivisceral Transplantation for Unresectable Mucinous Carcinoma Peritonei (TRANSCAPE)

Not Yet Recruiting
NCT02472054Phase 1

Treatment of Familiar Lymphohistiocytosis

Completed
NCT06959771Phase 1

Base Editing Hematopoietic Stem Cell and T Cell Gene Therapy for CD40L-HyperIgM Syndrome: Single Patient Study

Recruiting
NCT01659606Phase 2

Radiation- and Alkylator-free Bone Marrow Transplantation Regimen for Patients With Dyskeratosis Congenita

Active Not Recruiting
NCT05357482Phase 1

Addition of JSP191 (C-kit Antibody) to Nonmyeloablative Hematopoietic Cell Transplantation for Sickle Cell Disease and Beta-Thalassemia

Active Not Recruiting
NCT06872333Phase 2

Allo HSCT for High Risk Hemoglobinopathies

Recruiting
NCT06310343

ADAs to Alemtuzumab

Completed
NCT03504241Phase 1

Tolerance by Engaging Antigen During Cellular Homeostasis

Completed
NCT01625351Phase 1

A Study of CD45RA+ Depleted Haploidentical Stem Cell Transplantation in Children With Relapsed or Refractory Solid Tumors and Lymphomas

Completed
NCT03579875Phase 2

Alpha/Beta TCD HCT in Patients With Inherited BMF Disorders

Recruiting
NCT03500731Phase 1

Lung and Bone Marrow Transplantation for Lung and Bone Marrow Failure

Recruiting
NCT05384756Phase 1

TMLI and Alemtuzumab for Treatment of Sickle Cell Disease

Active Not Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
184