Success Metrics

Clinical Success Rate
75.9%

Based on 189 completed trials

Completion Rate
76%(189/249)
Active Trials
27(9%)
Results Posted
41%(77 trials)
Terminated
60(19%)

Phase Distribution

Ph early_phase_1
3
1%
Ph phase_1
144
45%
Ph phase_2
132
42%
Ph phase_3
24
8%
Ph phase_4
2
1%
Ph not_applicable
8
3%

Phase Distribution

147

Early Stage

132

Mid Stage

26

Late Stage

Phase Distribution313 total trials
Early Phase 1First-in-human
3(1.0%)
Phase 1Safety & dosage
144(46.0%)
Phase 2Efficacy & side effects
132(42.2%)
Phase 3Large-scale testing
24(7.7%)
Phase 4Post-market surveillance
2(0.6%)
N/ANon-phased studies
8(2.6%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

72.1%

189 of 262 finished

Non-Completion Rate

27.9%

73 ended early

Currently Active

27

trials recruiting

Total Trials

317

all time

Status Distribution
Active(28)
Completed(189)
Terminated(73)
Other(27)

Detailed Status

Completed189
Terminated60
unknown25
Recruiting19
Withdrawn13
Active, not recruiting8

Development Timeline

Analytics

Development Status

Total Trials
317
Active
27
Success Rate
75.9%
Most Advanced
Phase 4

Trials by Phase

Early Phase 13 (1.0%)
Phase 1144 (46.0%)
Phase 2132 (42.2%)
Phase 324 (7.7%)
Phase 42 (0.6%)
N/A8 (2.6%)

Trials by Status

recruiting196%
suspended21%
withdrawn134%
active_not_recruiting83%
completed18960%
terminated6019%
unknown258%
not_yet_recruiting10%

Recent Activity

Clinical Trials (317)

Showing 20 of 317 trialsScroll for more
NCT06904066Phase 1

Autologous T Cells Transduced With Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients With Hematologic Malignancies

Recruiting
NCT01955460Phase 1

Genetically Modified T-Cells Followed by Aldesleukin in Treating Patients With Stage III-IV Melanoma

Active Not Recruiting
NCT03412877Phase 2

Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in People With Metastatic Cancer

Recruiting
NCT01038778Phase 1

Entinostat in Combination With Aldesleukin in Treating Patients With Metastatic Kidney Cancer

Active Not Recruiting
NCT02621021Phase 2

A Phase 2 Trial for Metastatic Melanoma Using Adoptive Cell Therapy With Tumor Infiltrating Lymphocytes Plus IL-2 Either Alone or Following the Administration of Pembrolizumab

Recruiting
NCT06236425Phase 1

TBio-4101 and Pembro wi/ or w/o Chemo in Recurrent/Metastatic HNSCC

Active Not Recruiting
NCT02830724Phase 1

Administering Peripheral Blood Lymphocytes Transduced With a CD70-Binding Chimeric Antigen Receptor to People With CD70 Expressing Cancers

Recruiting
NCT05267626Phase 1

Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer

Recruiting
NCT06253520Phase 1

Autologous T-cells Genetically Engineered to Express Receptors Reactive Against KRAS Mutations in Conjunction With a Vaccine Directed Against These Antigens in Participants With Metastatic Cancer

Active Not Recruiting
NCT02133196Phase 2

T Cell Receptor Immunotherapy for Patients With Metastatic Non-Small Cell Lung Cancer

Recruiting
NCT03745326Phase 1

Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12D Variant of Mutated RAS in HLA-A*11:01 Patients

Completed
NCT02858310Phase 1

E7 TCR T Cells for Human Papillomavirus-Associated Cancers

Completed
NCT00026312Phase 3

Isotretinoin With or Without Dinutuximab, Aldesleukin, and Sargramostim Following Stem Cell Transplant in Treating Patients With Neuroblastoma

Completed
NCT01174121Phase 2

Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Cancer

Recruiting
NCT05639972Phase 1

E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated Cancers

Recruiting
NCT05686226Phase 2

E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers

Recruiting
NCT04426669Phase 1

A Study of Metastatic Gastrointestinal Cancers Treated With Tumor Infiltrating Lymphocytes in Which the Gene Encoding the Intracellular Immune Checkpoint CISH Is Inhibited Using CRISPR Genetic Engineering

Completed
NCT05566223Phase 1

CISH Inactivated TILs in the Treatment of NSCLC

Withdrawn
NCT07389239Phase 1

A Study Evaluating the Immunotherapy Treatment for Ovarian Cancer and Other Advanced Malignancies.

Not Yet Recruiting
NCT05155033Phase 2

Phase II Trial of Combination Anti-PD-1 and Aldesleukin for Metastatic Melanoma and Renal Cell Carcinoma

Recruiting

Drug Details

Intervention Type
BIOLOGICAL
Total Trials
317