Success Metrics

Clinical Success Rate
75.5%

Based on 188 completed trials

Completion Rate
76%(188/249)
Active Trials
28(9%)
Results Posted
41%(78 trials)
Terminated
61(19%)

Phase Distribution

Ph early_phase_1
3
1%
Ph phase_2
134
42%
Ph phase_3
24
8%
Ph phase_4
2
1%
Ph phase_1
145
45%
Ph not_applicable
8
3%

Phase Distribution

148

Early Stage

134

Mid Stage

26

Late Stage

Phase Distribution316 total trials
Early Phase 1First-in-human
3(0.9%)
Phase 1Safety & dosage
145(45.9%)
Phase 2Efficacy & side effects
134(42.4%)
Phase 3Large-scale testing
24(7.6%)
Phase 4Post-market surveillance
2(0.6%)
N/ANon-phased studies
8(2.5%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

71.8%

188 of 262 finished

Non-Completion Rate

28.2%

74 ended early

Currently Active

28

trials recruiting

Total Trials

320

all time

Status Distribution
Active(32)
Completed(188)
Terminated(74)
Other(26)

Detailed Status

Completed188
Terminated61
unknown25
Recruiting19
Withdrawn13
Active, not recruiting9

Development Timeline

Analytics

Development Status

Total Trials
320
Active
28
Success Rate
75.5%
Most Advanced
Phase 4

Trials by Phase

Early Phase 13 (0.9%)
Phase 1145 (45.9%)
Phase 2134 (42.4%)
Phase 324 (7.6%)
Phase 42 (0.6%)
N/A8 (2.5%)

Trials by Status

terminated6119%
withdrawn134%
unknown258%
recruiting196%
suspended10%
active_not_recruiting93%
completed18859%
not_yet_recruiting41%

Recent Activity

Clinical Trials (320)

Showing 20 of 320 trialsScroll for more
NCT06904066Phase 1

Autologous T Cells Transduced With Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients With Hematologic Malignancies

Recruiting
NCT05267626Phase 1

Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer

Recruiting
NCT05155033Phase 2

Phase II Trial of Combination Anti-PD-1 and Aldesleukin for Metastatic Melanoma and Renal Cell Carcinoma

Recruiting
NCT02830724Phase 1

Administering Peripheral Blood Lymphocytes Transduced With a CD70-Binding Chimeric Antigen Receptor to People With CD70 Expressing Cancers

Recruiting
NCT01174121Phase 2

Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Cancer

Recruiting
NCT07681596Phase 1

A Modular, Phase I/II, Multicentre Study to Evaluate AZD4045, in Participants With Relapsed or Refractory Multiple Myeloma

Not Yet Recruiting
NCT03412877Phase 2

Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in People With Metastatic Cancer

Recruiting
NCT05802056Phase 1

Aldesleukin With Nivolumab and Standard Chemotherapy for Treatment of Gastric Cancer With Peritoneal Metastasis

Active Not Recruiting
NCT01041638Phase 3

Monoclonal Antibody Ch14.18, Sargramostim, Aldesleukin, and Isotretinoin After Autologous Stem Cell Transplant in Treating Patients With Neuroblastoma

Completed
NCT07651618Phase 2

A Phase II Trial of Tumour Infiltrating Lymphocyte Adoptive Cell Therapy in Patients With Immune Checkpoint Inhibitor Resistant Unresectable or Metastatic Melanoma

Not Yet Recruiting
NCT07647068Phase 2

Autologous Tumor Infiltrating Lymphocytes With Interleukin-2 for the Treatment of Locally Advanced, Recurrent or Metastatic Gastrointestinal Stromal Tumors

Not Yet Recruiting
NCT05686226Phase 2

E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers

Recruiting
NCT05483491Phase 1

KK-LC-1 TCR-T Cell Therapy for Gastric, Breast, Cervical, and Lung Cancer

Recruiting
NCT05639972Phase 1

E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated Cancers

Recruiting
NCT02133196Phase 2

T Cell Receptor Immunotherapy for Patients With Metastatic Non-Small Cell Lung Cancer

Recruiting
NCT02621021Phase 2

A Phase 2 Trial for Metastatic Melanoma Using Adoptive Cell Therapy With Tumor Infiltrating Lymphocytes Plus IL-2 Either Alone or Following the Administration of Pembrolizumab

Recruiting
NCT03190941Phase 1

Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients

Recruiting
NCT03449108Phase 2

LN-145 or LN-145-S1 in Treating Patients With Relapsed or Refractory Ovarian Cancer, Triple Negative Breast Cancer (TNBC), Anaplastic Thyroid Cancer, Osteosarcoma, or Other Bone and Soft Tissue Sarcomas

Active Not Recruiting
NCT03745326Phase 1

Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12D Variant of Mutated RAS in HLA-A*11:01 Patients

Terminated
NCT05989828Phase 1

A2-ESO-1 TCR-Engineered T Cells for Relapsed/Refractory Advanced or Metastatic NY-ESO-1 Overexpression Positive Triple Negative Breast Cancer

Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
320