Success Metrics

Clinical Success Rate
83.3%

Based on 15 completed trials

Completion Rate
83%(15/18)
Active Trials
21(45%)
Results Posted
0%(0 trials)
Terminated
3(6%)

Phase Distribution

Ph early_phase_1
1
2%
Ph phase_1
12
26%
Ph phase_2
26
55%
Ph phase_3
7
15%

Phase Distribution

13

Early Stage

26

Mid Stage

7

Late Stage

Phase Distribution46 total trials
Early Phase 1First-in-human
1(2.2%)
Phase 1Safety & dosage
12(26.1%)
Phase 2Efficacy & side effects
26(56.5%)
Phase 3Large-scale testing
7(15.2%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

83.3%

15 of 18 finished

Non-Completion Rate

16.7%

3 ended early

Currently Active

21

trials recruiting

Total Trials

47

all time

Status Distribution
Active(25)
Completed(15)
Terminated(3)
Other(4)

Detailed Status

Completed15
Recruiting14
Active, not recruiting7
Not yet recruiting4
unknown4
Terminated3

Development Timeline

Analytics

Development Status

Total Trials
47
Active
21
Success Rate
83.3%
Most Advanced
Phase 3

Trials by Phase

Early Phase 11 (2.2%)
Phase 112 (26.1%)
Phase 226 (56.5%)
Phase 37 (15.2%)

Trials by Status

active_not_recruiting715%
completed1532%
not_yet_recruiting49%
terminated36%
unknown49%
recruiting1430%

Recent Activity

Clinical Trials (47)

Showing 20 of 47 trialsScroll for more
NCT05256472Phase 2

A Study of AK104 Monotherapy or AK104 Plus Axitinib in Advanced/Metastatic Renal Cell Carcinoma

Completed
NCT05235542Phase 1

A Phase Ib/II Study of AK104 and AK117 in Combination With or Without Chemotherapy in Advanced Malignant Tumors

Completed
NCT05215067Phase 2

A Phase II Trial of AK104 in Advanced Non-Small Cell Lung Cancer

Completed
NCT06477523Phase 1

Phase 1b/2 Study of LDRT in Combination With AK104 Plus Chemotherapy as First-line Treatment for ES-SCLC

Active Not Recruiting
NCT07052253Phase 2

A Phase II Clinical Study of AK104/AK112 in Combination With TT-00420 Tablet for Advanced HCC.

Recruiting
NCT05904379Phase 1

AK112 and AK104 With or Without Chemotherapy in Advanced Non-small Cell Lung Cancer

Active Not Recruiting
NCT05063916Phase 2

Phase II Study of AK104 (Cadonilimab) for Recurrent Small Cell Neuroendocrine Carcinomas of the Cervix

Active Not Recruiting
NCT04556253Phase 2

AK104 in Locally Advanced MSI-H/dMMR Gastric Carcinoma and Colorectal Cancer

Active Not Recruiting
NCT05021120Early Phase 1

A Study to Evaluate the Safety, Pharmacokinetics, and Antitumor Activity of AK127 in Combination With AK104 in Advanced and Metastatic Solid Tumours

Completed
NCT05008783Phase 3

A Study of AK104 in the First-line Treatment of Locally Advanced Unresectable or Metastatic G/GEJ Adenocarcinoma

Completed
NCT04982276Phase 1

A Study of AK109 and AK104 in Advanced Gastric Adenocarcinoma or Gastroesophageal Junction Adenocarcinoma

Recruiting
NCT04982237Phase 3

A Study of AK104 Plus Platinum-containing Chemotherapy±Bevacizumab as First-line Treatment for Persistent, Recurrent, or Metastatic Cervical Cancer

Active Not Recruiting
NCT06946836Phase 2

Comparison of Neoadjuvant Cadonilimab Versus Chemotherapy Combined With PD-1 in the Treatment of Resectable Non-Small Cell Lung Cancer With High PD-L1 Expression: A Single-Center, Randomized, Exploratory Clinical Study

Not Yet Recruiting
NCT05319431Phase 2

A Phase II Study of AK104 Plus Lenvatinib and TACE in HCC

Active Not Recruiting
NCT06371157Phase 3

A Study of AK104+Lenvatinib in Combination With Transarterial Chemoembolization (TACE) Versus TACE in Participants With Incurable/Non-metastatic Hepatocellular Carcinoma

Recruiting
NCT05932212Phase 2

AK104 for Recurrent or Metastatic Vulvar Cancer

Recruiting
NCT05489289Phase 3

A Phase III Study of AK104 as Adjuvant Therapy in HCC With High Risk of Recurrence After Curative Resection

Recruiting
NCT06560112Phase 2

An Exploratory, Multi-cohort Phase II Study of Combination Therapy With AK104 and AK112 for Recurrent Ovarian Cancer

Recruiting
NCT04868708Phase 2

A Study of AK104( an Anti-PD-1 and Anti-CTLA-4 Bispecific Antibody) in Recurrent or Metastatic Cervical Cancer

Completed
NCT04380805Phase 2

A Study of AK104, a PD-1/CTLA-4 Bispecific Antibody in Subjects With Recurrent/Metastatic Cervical Cancer

Completed

Drug Details

Intervention Type
DRUG
Total Trials
47