Success Metrics

Clinical Success Rate
100.0%

Based on 4 completed trials

Completion Rate
100%(4/4)
Active Trials
4(44%)
Results Posted
50%(2 trials)

Phase Distribution

Ph phase_1
5
56%
Ph phase_2
1
11%
Ph phase_3
2
22%

Phase Distribution

5

Early Stage

1

Mid Stage

2

Late Stage

Phase Distribution8 total trials
Phase 1Safety & dosage
5(62.5%)
Phase 2Efficacy & side effects
1(12.5%)
Phase 3Large-scale testing
2(25.0%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

100.0%

4 of 4 finished

Non-Completion Rate

0.0%

0 ended early

Currently Active

4

trials recruiting

Total Trials

9

all time

Status Distribution
Active(4)
Completed(4)
Other(1)

Detailed Status

Active, not recruiting4
Completed4
unknown1

Development Timeline

Analytics

Development Status

Total Trials
9
Active
4
Success Rate
100.0%
Most Advanced
Phase 3

Trials by Phase

Phase 15 (62.5%)
Phase 21 (12.5%)
Phase 32 (25.0%)

Trials by Status

active_not_recruiting444%
completed444%
unknown111%

Recent Activity

Clinical Trials (9)

Showing 9 of 9 trials
NCT02677922Phase 1

A Study to Assess the Safety and Efficacy of Two Combinations of Isocitrate Dehydrogenase (IDH) Mutant Targeted Therapies Plus Azacitidine in Participants With Newly Diagnosed Acute Myeloid Leukemia (AML) Harboring IDH Mutations Who Are Not Candidates to Receive Intensive Induction Chemotherapy

Active Not Recruiting
NCT02577406Phase 3

An Efficacy and Safety Study of AG-221 (CC-90007) Versus Conventional Care Regimens in Older Subjects With Late Stage Acute Myeloid Leukemia Harboring an Isocitrate Dehydrogenase 2 Mutation

Completed
NCT03744390Phase 2

IDH2 (AG 221) Inhibitor in Patients With IDH2 Mutated Myelodysplastic Syndrome

Active Not Recruiting
NCT02632708Phase 1

Safety Study of AG-120 or AG-221 in Combination With Induction and Consolidation Therapy in Participants With Newly Diagnosed Acute Myeloid Leukemia (AML) With an IDH1 and/or IDH2 Mutation

Active Not Recruiting
NCT03839771Phase 3

A Study of Ivosidenib or Enasidenib in Combination With Induction Therapy and Consolidation Therapy, Followed by Maintenance Therapy in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myedysplastic Syndrome EB2, With an IDH1 or IDH2 Mutation, Respectively, Eligible for Intensive Chemotherapy

Active Not Recruiting
NCT03723057

Expanded Access for AG-221

Unknown
NCT02443168Phase 1

Radiolabeled Study of AG-221 in Healthy Male Subjects.

Completed
NCT02387866Phase 1

PK and Safety Study of AG-221 in Healthy Male Japanese Subjects and Healthy Male Caucasian Subjects

Completed
NCT02218346Phase 1

Food Effect Study of AG-221 in Healthy Male Subjects

Completed

All 9 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
9