Success Metrics

Clinical Success Rate
83.3%

Based on 10 completed trials

Completion Rate
83%(10/12)
Active Trials
5(26%)
Results Posted
0%(0 trials)
Terminated
2(11%)

Phase Distribution

Ph phase_2
7
37%
Ph phase_1
12
63%

Phase Distribution

12

Early Stage

7

Mid Stage

0

Late Stage

Phase Distribution19 total trials
Phase 1Safety & dosage
12(63.2%)
Phase 2Efficacy & side effects
7(36.8%)

Highest Phase Reached

Phase 2

Trial Status & Enrollment

Completion Rate

76.9%

10 of 13 finished

Non-Completion Rate

23.1%

3 ended early

Currently Active

5

trials recruiting

Total Trials

19

all time

Status Distribution
Active(5)
Completed(10)
Terminated(3)
Other(1)

Detailed Status

Completed10
Active, not recruiting3
Terminated2
Recruiting2
unknown1
Withdrawn1

Development Timeline

Analytics

Development Status

Total Trials
19
Active
5
Success Rate
83.3%
Most Advanced
Phase 2

Trials by Phase

Phase 112 (63.2%)
Phase 27 (36.8%)

Trials by Status

active_not_recruiting316%
terminated211%
completed1053%
unknown15%
recruiting211%
withdrawn15%

Recent Activity

Clinical Trials (19)

Showing 19 of 19 trials
NCT03970447Phase 2

A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma

Recruiting
NCT05616624Phase 1

ADI-PEG 20 in Combination With Gemcitabine and Docetaxel After Progression on Frontline Therapy in Non-small Cell and Small Cell Lung Cancers

Active Not Recruiting
NCT06085729Phase 1

Phase I/II Study of PEGylated Arginine Deiminase (ADI-PEG20) With Carboplatin and Cabazitaxel in Men With Aggressive Variant Prostate Cancers (AVPC)

Recruiting
NCT05001828Phase 1

Study of ADI-PEG 20, Venetoclax and Azacitidine in Acute Myeloid Leukemia

Active Not Recruiting
NCT04587830Phase 2

ADI-PEG 20 Plus Radiotherapy and Temozolomide in Subjects With Glioblastoma Multiforme

Active Not Recruiting
NCT06006286Phase 1

A Study Evaluating Atezolizumab and Bevacizumab Plus ADI-PEG 20 in Patients With Locally Advanced / Metastatic Hepatocellular Carcinoma

Withdrawn
NCT02101580Phase 1

Ph 1B Trial With ADI-PEG 20 Plus Nab-Paclitaxel and Gemcitabine in Subjects With Pancreatic Cancer

Completed
NCT01910012Phase 2

PH 2 ADI-PEG 20 Acute Myeloid Leukemia

Completed
NCT02029690Phase 1

Ph 1 Study in Subjects With Tumors Requiring Arginine to Assess ADI-PEG 20 With Pemetrexed and Cisplatin

Terminated
NCT02875093Phase 1

Ph 1 Study of ADI-PEG 20 Plus Low Dose Cytarabine in Older Patients With AML

Terminated
NCT01910025Phase 2

PH 2 ADI-PEG 20 Study in Non-Hodgkin's Lymphoma Subjects Who Have Failed Prior Systemic Therapy

Completed
NCT01497925Phase 1

Ph 1 Trial of ADI-PEG 20 Plus Docetaxel in Solid Tumors With Emphasis on Prostate Cancer and Non-Small Cell Lung Cancer

Completed
NCT02006030Phase 2

Ph 2 Trial of ADI PEG 20 Plus Concurrent Transarterial Chemoembolization (TACE) Vs TACE Alone in Patients With Unresectable Hepatocellular Carcinoma

Completed
NCT01948843Phase 1

Ph 1 ADI-PEG 20 Plus Doxorubicin; Patients With HER2 Negative Metastatic Breast Cancer

Completed
NCT02101593Phase 1

Ph 1 Trial of ADI PEG 20 Plus Sorafenib to Treat Patients With Liver Cancer

Completed
NCT01665183Phase 1

Ph 1 Trial of ADI-PEG 20 Plus Cisplatin in Patients With Metastatic Melanoma

Completed
NCT00056992Phase 2

Testing of ADI-PEG in Hepatocellular Carcinoma

Completed
NCT01279967Phase 2

A Clinical Trial of ADI-PEG 20TM in Patients With Malignant Pleural Mesothelioma

Unknown
NCT01528384Phase 1

Ph 1 Study of ADI PEG 20 in Pediatric Subjects Who Are Argininosuccinate Synthetase (ASS) Deficient

Completed

All 19 trials loaded

Drug Details

Intervention Type
BIOLOGICAL
Total Trials
19