Success Metrics

Clinical Success Rate
82.4%

Based on 14 completed trials

Completion Rate
82%(14/17)
Active Trials
0(0%)
Results Posted
79%(11 trials)
Terminated
3(15%)

Phase Distribution

Ph phase_3
6
30%
Ph phase_1
6
30%
Ph phase_2
8
40%

Phase Distribution

6

Early Stage

8

Mid Stage

6

Late Stage

Phase Distribution20 total trials
Phase 1Safety & dosage
6(30.0%)
Phase 2Efficacy & side effects
8(40.0%)
Phase 3Large-scale testing
6(30.0%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

70.0%

14 of 20 finished

Non-Completion Rate

30.0%

6 ended early

Currently Active

0

trials recruiting

Total Trials

20

all time

Status Distribution
Completed(14)
Terminated(6)

Detailed Status

Completed14
Terminated3
Withdrawn3

Development Timeline

Analytics

Development Status

Total Trials
20
Active
0
Success Rate
82.4%
Most Advanced
Phase 3

Trials by Phase

Phase 16 (30.0%)
Phase 28 (40.0%)
Phase 36 (30.0%)

Trials by Status

terminated315%
completed1470%
withdrawn315%

Recent Activity

Clinical Trials (20)

Showing 20 of 20 trials
NCT02961218Phase 2

Study of Efficacy, Safety and Tolerability of ACZ885 (Canakinumab) in Pediatric and Young Adult Patients With Sickle Cell Anemia

Completed
NCT03484923Phase 2

Study of Efficacy and Safety of Novel Spartalizumab Combinations in Patients With Previously Treated Unresectable or Metastatic Melanoma

Completed
NCT02900664Phase 1

A Study of PDR001 in Combination With CJM112, EGF816, Ilaris® (Canakinumab) or Mekinist® (Trametinib)

Completed
NCT02888080Phase 2

Study of Efficacy, Safety and Tolerability of ACZ885 (Canakinumab) in Patients With Pulmonary Sarcoidosis

Completed
NCT01364389Phase 2

A 3-arm Proof of Concept Study of AIN457, ACZ885 or Corticosteroids in Patients With Polymyalgia Rheumatica

Terminated
NCT01470989Phase 3

β-RELIEVED - REsponse in Acute fLare and In prEVEntion of episoDes of Re-flare in Gout - Extension 3 (E3)

Completed
NCT02007252Phase 2

ACZ885 for the Treatment of Abdominal Aortic Aneurysm

Terminated
NCT01576367Phase 3

Efficacy, Safety and Tolerability of ACZ885 in Pediatric Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory Disease

Completed
NCT00465985Phase 3

Efficacy, Safety, and Tolerability of ACZ885 in Patients With Muckle-Wells Syndrome

Completed
NCT01593527Phase 3

Canakinumab in the Treatment of Gouty Arthritis Flare(s) and Prevention of New Flares in Patients With Chronic Kidney Disease

Withdrawn
NCT01302860Phase 3

Efficacy, Safety and Tolerability of ACZ885 in Pediatric Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory Disease

Completed
NCT01242813Phase 2

Efficacy and Safety Study of ACZ885 in Patients With Active Recurrent or Chronic TNF-receptor Associated Periodic Syndrome (TRAPS).

Completed
NCT01676948Phase 3

An Open-label, Multi-arm, Non-comparative Safety and Tolerability Study of Canakinumab (ACZ885) in Patients With Active Systemic Juvenile Idiopathic Arthritis (SJIA)

Withdrawn
NCT00995930Phase 2

Safety & Effectiveness on Vascular Structure and Function of ACZ885 in Atherosclerosis and Either T2DM or IGT Patients

Completed
NCT01322321Phase 2

ACZ885 in Type 1 Diabetes Mellitus

Withdrawn
NCT00421226Phase 1

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ACZ885 in Healthy Japanese Male Volunteers

Completed
NCT00426218Phase 1

Safety, Efficacy and Pharmacokinetics of Subcutaneous ACZ885 in Patients With Systemic Juvenile Idiopathic Arthritis (SJIA)

Completed
NCT00505089Phase 1

Efficacy and Safety of Subcutaneous Versus Intravenous ACZ885 in Adult Patients With Established Rheumatoid Arthritis

Terminated
NCT00619905Phase 1

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ACZ885 in Patients With Rheumatoid Arthritis With Ongoing Treatment With Methotrexate

Completed
NCT00503022Phase 1

Safety and Tolerability of an Intravenous Infusion of ACZ885 in Patients With Wet Age-Related Macular Degeneration

Completed

All 20 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
20