Success Metrics

Clinical Success Rate
84.4%

Based on 27 completed trials

Completion Rate
84%(27/32)
Active Trials
76(63%)
Results Posted
126%(34 trials)
Terminated
5(4%)

Phase Distribution

Ph early_phase_1
1
1%
Ph phase_4
1
1%
Ph phase_1
33
27%
Ph phase_2
64
53%
Ph phase_3
17
14%
Ph not_applicable
2
2%

Phase Distribution

34

Early Stage

64

Mid Stage

18

Late Stage

Phase Distribution118 total trials
Early Phase 1First-in-human
1(0.8%)
Phase 1Safety & dosage
33(28.0%)
Phase 2Efficacy & side effects
64(54.2%)
Phase 3Large-scale testing
17(14.4%)
Phase 4Post-market surveillance
1(0.8%)
N/ANon-phased studies
2(1.7%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

71.1%

27 of 38 finished

Non-Completion Rate

28.9%

11 ended early

Currently Active

76

trials recruiting

Total Trials

121

all time

Status Distribution
Active(80)
Completed(27)
Terminated(11)
Other(3)

Detailed Status

Active, not recruiting41
Recruiting35
Completed27
Withdrawn6
Terminated5
Not yet recruiting4

Development Timeline

Analytics

Development Status

Total Trials
121
Active
76
Success Rate
84.4%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (0.8%)
Phase 133 (28.0%)
Phase 264 (54.2%)
Phase 317 (14.4%)
Phase 41 (0.8%)
N/A2 (1.7%)

Trials by Status

withdrawn65%
recruiting3529%
completed2722%
unknown32%
terminated54%
active_not_recruiting4134%
not_yet_recruiting43%

Recent Activity

Clinical Trials (121)

Showing 20 of 121 trialsScroll for more
NCT04566887Phase 2

Acalabrutinib With R-CHOP in Previously Untreated Mantle Cell Lymphoma

Active Not Recruiting
NCT06136559Phase 3

A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)

Recruiting
NCT04505254Phase 2

Acalabrutinib and Obinutuzumab for the Treatment of Chronic Lymphocytic Leukemia

Active Not Recruiting
NCT06564038Phase 1

A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies

Recruiting
NCT04548648Phase 2

A Pilot Study of Acalabrutinib in Relapsed/Refractory Primary and Secondary CNS Lymphomas

Active Not Recruiting
NCT04722172Phase 2

A Study on Limiting Treatment Time With Acalabrutinib Combined With Obinutuzumab in People With CLL or SLL

Active Not Recruiting
NCT04002947Phase 2

Acalabrutinib With DA-EPOCH-R or R-CHOP for People With Untreated Diffuse Large B-cell Lymphoma

Recruiting
NCT07277231Phase 3

A Study to Investigate Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Acalabrutinib in Adults With Previously Untreated Chronic Lymphocytic Leukemia

Recruiting
NCT05952024Phase 2

Study of Acalabrutinib and Rituximab in Untreated Elderly and/or Frail Patients With DLBCL

Recruiting
NCT05557695

Observational Study of Acalabrutinib in Patients With Chronic Lymphocytic Leukaemia in the United Kingdom

Recruiting
NCT02972840Phase 3

A Study of BR Alone Versus in Combination With Acalabrutinib in Subjects With Previously Untreated MCL

Active Not Recruiting
NCT05951959Phase 2

A Study of Acalabrutinib Plus Venetoclax and Rituximab in Participants With Treatment Naïve Mantle Cell Lymphoma

Active Not Recruiting
NCT02477696Phase 3

Study of Acalabrutinib (ACP-196) Versus Ibrutinib in Previously Treated Participants With High Risk Chronic Lymphocytic Leukemia (CLL)

Active Not Recruiting
NCT04765111Phase 2

Acalabrutinib and Rituximab for the Treatment of Previously Untreated Mantle Cell Lymphoma

Active Not Recruiting
NCT07257055Phase 2

Phase 2 Study of BTKi-Rituximab Induction Followed by Glofitamab Consolidation in High Risk Untreated MCL Patients - WINDOW-4 Study

Recruiting
NCT05495464Early Phase 1

A Pilot "Window-3" Study of Acalabrutinib Plus Rituximab Followed by Brexucabtagene Autoleucel Therapy in Patients With Previously Untreated High-risk Mantle Cell Lymphoma

Active Not Recruiting
NCT04404088Phase 2

Acalabrutinib, Lenalidomide, and Rituximab for the Treatment of CD20 Positive Stage III-IV, Grade 1-3a Follicular Lymphoma

Active Not Recruiting
NCT05057494Phase 3

A Study of Acalabrutinib Plus Venetoclax Versus Venetoclax Plus Obinutuzumab in Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Active Not Recruiting
NCT04941716Phase 2

Acalabrutinib in Combination With Venetoclax for the Treatment of Refractory or Recurrent Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma, The AVENUE-2 Trial

Recruiting
NCT06651970Phase 4

Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart Failure

Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
121