Success Metrics

Clinical Success Rate
75.0%

Based on 9 completed trials

Completion Rate
75%(9/12)
Active Trials
2(11%)
Results Posted
111%(10 trials)
Terminated
3(17%)

Phase Distribution

Ph phase_1
7
39%
Ph phase_2
8
44%
Ph early_phase_1
3
17%

Phase Distribution

10

Early Stage

8

Mid Stage

0

Late Stage

Phase Distribution18 total trials
Early Phase 1First-in-human
3(16.7%)
Phase 1Safety & dosage
7(38.9%)
Phase 2Efficacy & side effects
8(44.4%)

Highest Phase Reached

Phase 2

Trial Status & Enrollment

Completion Rate

60.0%

9 of 15 finished

Non-Completion Rate

40.0%

6 ended early

Currently Active

2

trials recruiting

Total Trials

18

all time

Status Distribution
Active(2)
Completed(9)
Terminated(6)
Other(1)

Detailed Status

Completed9
Terminated3
Withdrawn3
Recruiting2
unknown1

Development Timeline

Analytics

Development Status

Total Trials
18
Active
2
Success Rate
75.0%
Most Advanced
Phase 2

Trials by Phase

Early Phase 13 (16.7%)
Phase 17 (38.9%)
Phase 28 (44.4%)

Trials by Status

terminated317%
recruiting211%
unknown16%
withdrawn317%
completed950%

Recent Activity

Clinical Trials (18)

Showing 18 of 18 trials
NCT05317000Phase 2

5-Azacytidine and/or Nivolumab in Resectable HPV-Associated HNSCC

Recruiting
NCT06466798Phase 1

Fourth Ventricular Administration of Immune Checkpoint Inhibitor (Nivolumab) and Methotrexate or 5-Azacytidine for Recurrent Medulloblastoma, Ependymoma, and Other CNS Malignancies

Withdrawn
NCT06598332Early Phase 1

5-Azacytidine With Steroids for Gastrointestinal GVHD (5-AZA FOR GVHD)

Withdrawn
NCT04187703Early Phase 1

5-Azacitidine and Decitabine Epigenetic Therapy for Myeloid Malignancies

Recruiting
NCT02096042Phase 1

Phase I/II - Brentuximab/5-Azacytidine in Acute Myeloid Leukemia (AML)

Terminated
NCT03825367Phase 1

Nivolumab in Combination With 5-azacytidine in Childhood Relapsed/Refractory AML

Unknown
NCT02497404Phase 2

Azacytidine Prior to in Vivo T-cell Depleted Allo Stem Cell Transplant for Patients With Myeloid Malignancies in CR

Completed
NCT00946647Phase 1

A Phase Ib/IIb, Open-label, Multi-center, Study of Oral Panobinostat Administered With 5-Azacitidine (in Adult Patients With Myelodysplastic Syndromes (MDS), Chronic Myelomonocytic Leukemia (CMML), or Acute Myeloid Leukemia (AML).

Completed
NCT02940483Early Phase 1

Infusion of 5-Azacytidine (5-AZA) Into the Fourth Ventricle in Children With Recurrent Posterior Fossa Ependymoma

Completed
NCT01202877Phase 1

PKC412 and 5-Azacytidine

Completed
NCT00439673Phase 2

PhII 5-Azacytidine Plus Valproic Acid and Eventually Atra in Intermediate II and High Risk MDS

Completed
NCT02829840Phase 1

Dose-Escalation Study of Ponatinib, a FLT3 Inhibitor, With and Without Combination of 5-Azacytidine, in Patients With FLT3-Mutated Acute Myeloid Leukemia (AML)

Withdrawn
NCT00997243Phase 2

Azacitidine and Lintuzumab in Treating Patients With Previously Untreated Myelodysplastic Syndromes

Terminated
NCT01038635Phase 1

5-Azacytidine With Lenalidomide in Patients With High Risk Myelodysplastic Syndrome (MDS) and Acute Myelogenous Leukemia (AML)

Completed
NCT00721214Phase 2

5-Azacytidine Prior to Allogeneic Stem Cell Transplant in High Risk Myelodysplastic Syndrome

Completed
NCT00413478Phase 2

5-Azacytidine (Azacytidine; Vidaza) in Chronic Lymphocytic Leukemia

Terminated
NCT00382590Phase 2

Azacytidine With Valproic Acid Versus Ara-C in Acute Myeloid Leukemia (AML)/ Myelodysplastic Syndrome (MDS) Patients

Completed
NCT00005934Phase 2

5-Azacytidine and Phenylbutyrate to Treat Severe Thalassemia

Completed

All 18 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
18