Key Insights

Highlights

Success Rate

82% trial completion

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 62/100

Termination Rate

10.7%

6 terminated out of 56 trials

Success Rate

81.8%

-4.7% vs benchmark

Late-Stage Pipeline

25%

14 trials in Phase 3/4

Results Transparency

37%

10 of 27 completed with results

Key Signals

10 with results82% success

Data Visualizations

Phase Distribution

46Total
Not Applicable (2)
Early P 1 (1)
P 1 (18)
P 2 (11)
P 3 (12)
P 4 (2)

Trial Status

Completed27
Unknown7
Terminated6
Recruiting5
Active Not Recruiting5
Not Yet Recruiting3

Trial Success Rate

81.8%

Benchmark: 86.5%

Based on 27 completed trials

Clinical Trials (56)

Showing 20 of 20 trials
NCT06556368Phase 3Active Not RecruitingPrimary

A Study to Evaluate the Efficacy and Safety of Tarcocimab Tedromer and Tabirafusp Tedromer Compared to Aflibercept in Participants With Neovascular (Wet) Age-related Macular Degeneration (wAMD) - DAYBREAK

NCT04704921Phase 2Active Not Recruiting

Pivotal 1 Study of ABBV-RGX-314 (Also Known as RGX-314) Gene Therapy Administered Via Subretinal Delivery One Time in Participants With nAMD

NCT05407636Phase 3Recruiting

Pivotal 2 Study of RGX-314 Gene Therapy in Participants With nAMD

NCT04504123Phase 2Recruiting

MMP-9 Inhibition for Recalcitrant Wet AMD

NCT04645212Active Not RecruitingPrimary

Long-term Study of ADVM-022 in Neovascular (Wet) AMD [OPTIC-EXT]

NCT07389577Phase 3CompletedPrimary

A Study to Compare JL14002 to Lucentis® in Subjects With Wet Age-related Macular Degeneration (wAMD)

NCT07338513Not Yet Recruiting

User-centric Study of Patients' Receptiveness Towards the Web-based Automated Vision Impairment Gaze-tracking Analysis Systems

NCT06518512Active Not Recruiting

Automated Vision Assessment and Impairment Detection Through Gaze Analysis in Wet AMD Patients

NCT04932980Not ApplicableActive Not RecruitingPrimary

Comparison of Rapid Aflibercept and Brolucizumab T&E in wAMD

NCT06952452Phase 3RecruitingPrimary

Pharmacogenomics of antiVEGF in Patients With Age-Associated Macular Degeneration (AMD)

NCT05381948Phase 2CompletedPrimary

Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD)

NCT07178249Phase 1Not Yet RecruitingPrimary

Evaluating the Safety and Preliminary Efficacy of EXG202 Gene Therapy for Neovascular AMD

NCT06859515RecruitingPrimary

A Long-term Follow up Study of EXG102-031 in Participants With wAMD

NCT03585556Phase 1CompletedPrimary

AAVCAGsCD59 for the Treatment of Wet AMD

NCT06888492Early Phase 1Not Yet Recruiting

To Evaluate the Safety and Preliminary Efficacy of Intravitreal EXG202 Injection in Patients with Wet (neovascular) Age-related Macular Degeneration (wAMD)

NCT06875245Phase 4RecruitingPrimary

Comparing Efficacy of 8-Week and 12-Week Faricimab Initial Follow-Up Treatment Intervals

NCT03939767CompletedPrimary

Assessment of Proactive Treatments in Patients With Wet Age-related Macular Degeneration (wAMD) Which Have Never Undergone Treatment of This Particular Disease

NCT04832724Phase 2Completed

RGX-314 Gene Therapy Pharmacodynamic Study for Neovascular Age-related Macular Degeneration (nAMD)

NCT04964089Phase 3CompletedPrimary

A Study to Evaluate the Efficacy and Safety of Intravitreal KSI-301 Compared With Intravitreal Aflibercept in Participants With Neovascular (Wet) Age-related Macular Degeneration (wAMD)

NCT05141994Phase 2CompletedPrimary

Clinical Study on the Efficacy and Safety of BAT5906 Injection

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