Key Insights

Highlights

Success Rate

57% trial completion

Published Results

29 trials with published results (38%)

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 65/100

Termination Rate

22.1%

17 terminated out of 77 trials

Success Rate

57.5%

-29.0% vs benchmark

Late-Stage Pipeline

13%

10 trials in Phase 3/4

Results Transparency

126%

29 of 23 completed with results

Key Signals

29 with results57% success17 terminated

Data Visualizations

Phase Distribution

65Total
P 1 (29)
P 2 (26)
P 3 (10)

Trial Status

Completed23
Terminated17
Recruiting17
Active Not Recruiting12
Withdrawn4
Not Yet Recruiting4

Trial Success Rate

57.5%

Benchmark: 86.5%

Based on 23 completed trials

Clinical Trials (77)

Showing 20 of 20 trials
NCT06822010Phase 2Recruiting

SeqUential GeMcitabine and MITomycin Treatment for Favorable High-Risk Upper Urinary Tract Urothelial Carcinoma

NCT07566156Phase 3Not Yet RecruitingPrimary

Enfortumab Vedotin in Combination With Pembrolizumab vs. Concurrent Chemoradiotherapy (cCRT) in People With Muscle Invasive Bladder Cancer ( EV-309 )

NCT05645692Phase 2Active Not RecruitingPrimary

A Study Evaluating Different Immunotherapies (LAG-3 and PD-1 With or Without TIGIT, Compared to PD-L1 Alone) in Participants With Untreated Locally Advanced Metastatic Urothelial Cancer

NCT04114136Phase 2Recruiting

Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies

NCT04235777Phase 1RecruitingPrimary

Bintrafusp Alfa (M7824) and PDS01ADC Alone and in Combination With Stereotactic Body Radiation Therapy (SBRT) in Adults With Metastatic Non-Prostate Genitourinary Malignancies

NCT05219435Phase 2CompletedPrimary

Study of NIVOLUMAB/IPILIMUMAB Maintenance in Unresectable Locally Advanced or Metastatic Urothelial Cancer

NCT07545122Phase 1Not Yet Recruiting

A Phase 1a/1b, First-Time-in-Human Study of CT-202, a Nectin-4 Directed Bispecific Antibody, in Participants With Recurring Triple Negative Breast, Colorectal, Urothelial Cancers

NCT02516241Phase 3Active Not RecruitingPrimary

Study of MEDI4736 (Durvalumab) With or Without Tremelimumab Versus Standard of Care Chemotherapy in Urothelial Cancer

NCT07421700Phase 1RecruitingPrimary

Symbiotic-GU-06: A Study to Learn About PF-08634404 Alone or In Combination With Enfortumab Vedotin in Urothelial Cancer

NCT07193511Phase 1Recruiting

BEACON-1: Study of AVZO-103 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Urothelial Cancer or Other Solid Tumors (AVZO-103-1001)

NCT07106762Phase 2RecruitingPrimary

Phase 2/3 Trial of Izalontamab Brengitecan vs Platinum-based Chemotherapy for Metastatic Urothelial Cancer With Disease Progression on or After Immunotherapy

NCT06011954RecruitingPrimary

A Study to Survey Adults in South Korea With Cancer Who Receive PADCEV Injection

NCT05059522Phase 3Active Not Recruiting

Continued Access Study for Participants Deriving Benefit in Pfizer-Sponsored Avelumab Parent Studies That Are Closing

NCT03390504Phase 3Active Not RecruitingPrimary

A Study of Erdafitinib Compared With Vinflunine or Docetaxel or Pembrolizumab in Participants With Advanced Urothelial Cancer and Selected Fibroblast Growth Factor Receptor (FGFR) Gene Aberrations

NCT02365597Phase 2Active Not RecruitingPrimary

An Efficacy and Safety Study of Erdafitinib (JNJ-42756493) in Participants With Urothelial Cancer

NCT07140315Phase 1Recruiting

DK222 Study at Hopkins

NCT02379429Recruiting

Care of the Urothelial Cancer Patient and Prospective Procurement of Urothelial Cancer Tissue

NCT03288545Phase 1Terminated

A Study of Enfortumab Vedotin Alone or With Other Therapies for Treatment of Urothelial Cancer

NCT07129993Phase 2RecruitingPrimary

Study of Datopotamab Deruxtecan Plus Carboplatin or Cisplatin Versus Gemcitabine Plus Carboplatin or Cisplatin in Participants With Locally Advanced or Metastatic Urothelial Carcinoma

NCT05489211Phase 2Recruiting

Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)

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