Key Insights

Highlights

Success Rate

91% trial completion (above average)

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 40/100

Termination Rate

5.6%

2 terminated out of 36 trials

Success Rate

91.3%

+4.8% vs benchmark

Late-Stage Pipeline

14%

5 trials in Phase 3/4

Results Transparency

29%

6 of 21 completed with results

Key Signals

6 with results91% success

Data Visualizations

Phase Distribution

20Total
Not Applicable (2)
P 2 (13)
P 3 (3)
P 4 (2)

Trial Status

Completed21
Recruiting5
Active Not Recruiting4
Not Yet Recruiting2
Terminated2
Unknown2

Trial Success Rate

91.3%

Benchmark: 86.5%

Based on 21 completed trials

Clinical Trials (36)

Showing 20 of 20 trials
NCT03828201Phase 2Active Not RecruitingPrimary

Efficacy and Tolerability of Bedaquiline, Delamanid, Levofloxacin, Linezolid, and Clofazimine to Treat MDR-TB

NCT01212003Recruiting

Training Protocol on the Natural History of Tuberculosis

NCT02354014Phase 2RecruitingPrimary

Pharmacokinetic Study to Evaluate Anti-mycobacterial Activity of TMC207 in Combination With Background Regimen (BR) of Multidrug Resistant Tuberculosis (MDR-TB) Medications for Treatment of Children/Adolescents With Pulmonary MDR-TB

NCT05117788Active Not RecruitingPrimary

Bioneer Q-RFIA Clinical Evaluation

NCT06441006Phase 2Recruiting

Program for Rifampicin-Resistant Disease With Stratified Medicine for Tuberculosis

NCT05007821Phase 2Active Not RecruitingPrimary

Linezolid Dosing Strategies in Drug-Resistant TB

NCT02715271Completed

Study of TB Lesions Obtained in Therapeutical Surgery

NCT02754765Phase 3CompletedPrimary

Evaluating Newly Approved Drugs for Multidrug-resistant TB

NCT03896685Phase 3CompletedPrimary

Evaluating Newly Approved Drugs in Combination Regimens for Multidrug-Resistant TB With Fluoroquinolone Resistance (endTB-Q)

NCT02365623Phase 2CompletedPrimary

An Exploratory Study of TMC207 in Japanese Participants With Pulmonary Multi-Drug Resistant Tuberculosis (MDR-TB)

NCT04179500Phase 2Completed

A Trial to Evaluate the Male Reproductive Safety of Pretomanid in Adult Male Participants With Drug Resistant Pulmonary Tuberculosis

NCT02619994Phase 2CompletedPrimary

Treatment Shortening of MDR-TB Using Existing and New Drugs

NCT05871489Active Not RecruitingPrimary

Strengthening Evidence on Optimal Multidrug-resistant Tuberculosis Treatment Regimens

NCT06674291Not Yet RecruitingPrimary

Registry on the Effectiveness and Safety of the 9-month MDR-END Treatment Regimen in Korean Patients with FQ-sensitive MDR-TB (MDR-END Registry)

NCT05022238RecruitingPrimary

Hotspots, Households and Hospitals: Enhanced Drug-resistant Tuberculosis Case Finding in Namibia

NCT02589782Phase 2CompletedPrimary

Pragmatic Clinical Trial for a More Effective Concise and Less Toxic MDR-TB Treatment Regimen(s)

NCT02413931CompletedPrimary

Nosocomial Transmission of MDR-TB in Bucharest, Romania

NCT02597621CompletedPrimary

Biomarkers for Therapy Response in Drug-resistant Tuberculosis

NCT03338621Phase 2Completed

Trial to Evaluate the Efficacy, Safety and Tolerability of BPaMZ in Drug-Sensitive (DS-TB) Adult Patients and Drug-Resistant (DR-TB) Adult Patients

NCT04783727Not ApplicableTerminated

PredictEndTB Signature for Individualizing Treatment in Multidrug-Resistant Tuberculosis

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