Treatment Resistant Depression
215
44
65
81
Key Insights
Highlights
Success Rate
87% trial completion (above average)
Published Results
39 trials with published results (18%)
Research Maturity
81 completed trials (38% of total)
Clinical Risk Assessment
Based on trial outcomes
Low Risk
Score: 27/100
5.6%
12 terminated out of 215 trials
87.1%
+0.6% vs benchmark
16%
34 trials in Phase 3/4
48%
39 of 81 completed with results
Key Signals
Data Visualizations
Phase Distribution
Trial Status
Trial Success Rate
Benchmark: 86.5%
Based on 81 completed trials
Clinical Trials (215)
Natural History of Depression, Bipolar Disorder and Suicide Risk
Treatment With Psilocybin for Chronic Neuropathic Pain and Depression (TRANSCEND)
Imaging the Effects of Serotonin 2A Receptor Modulation on Synaptic Density in Treatment-resistant Depression (SYNVEST)
Personalized Therapeutic Neuromodulation for Anhedonic Depression
Accelerated Theta Burst in Treatment-Resistant Depression: A Dose Finding and Biomarker Study
Working Mechanisms and Effectiveness of IV Ketamine-assisted Psychotherapy on Depression in TRD Clients
Tractography Guided Subcallosal Cingulate Deep Brain Stimulation for Treatment Resistant Depression
Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression
An Open-Label Study to Evaluate the Safety, Tolerability and Pharmacodynamics of BPL-003 in Patients With Treatment Resistant Depression
Ketamine Associated ACC GABA and Glutamate Change and Depression Remission:
Accelerated Intermittent Theta-Burst Stimulation (aiTBS) in Treatment-Resistant Depression of Bipolar II Disorder
Specialized Pro-resolving Lipid Mediators and Treatment Resistant Depression
Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
A Randomized, Double-Blind Controlled Comparison of NRX-101 vs. Placebo for Adults Being Treated With Robotic Transcranial Magnetic Stimulation for Treatment Resistant Depression: The SPARC-TMS Trial
DBS for TRD With the Medtronic Summit RC+S
Transcranial Ultrasonic Stimulation in Treatment-resistant Depression : an Open-label Pilot Trial
DBS for TRD With the Medtronic Percept PC
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
DBS for Depression
Exercise to Augment TMS in Those With Treatment Resistant Depression