Key Insights

Highlights

Success Rate

95% trial completion (above average)

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 40/100

Termination Rate

2.6%

1 terminated out of 39 trials

Success Rate

95.0%

+8.5% vs benchmark

Late-Stage Pipeline

13%

5 trials in Phase 3/4

Results Transparency

26%

5 of 19 completed with results

Key Signals

5 with results95% success

Data Visualizations

Phase Distribution

17Total
Not Applicable (4)
Early P 1 (4)
P 2 (4)
P 3 (4)
P 4 (1)

Trial Status

Completed19
Recruiting7
Unknown5
Enrolling By Invitation2
Active Not Recruiting2
Withdrawn2

Trial Success Rate

95.0%

Benchmark: 86.5%

Based on 19 completed trials

Clinical Trials (39)

Showing 20 of 20 trials
NCT05758493Phase 2Recruiting

Characterizing Iodine-124 Evuzumitide (AT-01) in Systemic Amyloidosis

NCT07205666RecruitingPrimary

The Eplontersen Pregnancy and Lactation Outcomes Study

NCT06563895Phase 3Recruiting

Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant

NCT06465810RecruitingPrimary

Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis

NCT03431896Completed

Monitoring of Early Disease Progression in Hereditary Transthyretin Amyloidosis

NCT07238426Enrolling By Invitation

ATTRACT-52: Primary Care Cardiac Amyloidosis Screening in Ordu, Turkey

NCT05023889Early Phase 1Active Not Recruiting

Spectrum of Peripheral and Autonomic Neuropathies in Patients With aTTRwt Amyloidosis and Response to Patisiran Therapy

NCT03759379Phase 3Completed

HELIOS-A: A Study of Vutrisiran (ALN-TTRSC02) in Patients With Hereditary Transthyretin Amyloidosis (hATTR Amyloidosis)

NCT05873868Active Not RecruitingPrimary

Myocardial Effects in Patients With ATTRv With Polyneuropathy Treated With Patisiran or Vutrisiran

NCT04569903Early Phase 1WithdrawnPrimary

Evaluation of a Claims-based Algorithm for the Identification of Transthyretin-mediated Amyloidosis (ATTR) Amyloidosis in Medical Records

NCT04276220Not ApplicableCompletedPrimary

Prevalence of wtATTR-CM After Carpal Tunnel Release Surgery

NCT06291805RecruitingPrimary

Phenotyping and Characterization of wtATTR-CM (TRACE 1)

NCT05635045Phase 2CompletedPrimary

Evuzamitide in PET/CT to Measure Potential Therapeutic Response in ATTR

NCT03237494CompletedPrimary

TRAMmoniTTR Study Genetic Screening of an At-risk Population for hATTR and Monitoring of TTR Positive Subjects

NCT06921408Not Yet Recruiting

Retrospective Identification of Scintigraphic Cardiac Amyloidosis (RISCA)

NCT05577819Not ApplicableRecruitingPrimary

Prevalence and Prediction of ATTR in Ambulatory Patients With HFpEF

NCT06714019Enrolling By Invitation

PL_GNT01_ISR_Grant 53234273

NCT00628745Completed

Transthyretin Amyloidosis Outcome Survey (THAOS)

NCT04899180Early Phase 1Completed

Prevalence of Transthyretin Cardiac Amyloidosis in Clinically Significant Aortic Stenosis

NCT03860935Phase 3Completed

Efficacy and Safety of AG10 in Subjects With Transthyretin Amyloid Cardiomyopathy

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