Key Insights

Highlights

Success Rate

80% trial completion

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 62/100

Termination Rate

3.6%

1 terminated out of 28 trials

Success Rate

80.0%

-6.5% vs benchmark

Late-Stage Pipeline

0%

0 trials in Phase 3/4

Results Transparency

25%

1 of 4 completed with results

Key Signals

1 with results80% success

Data Visualizations

Phase Distribution

25Total
Early P 1 (1)
P 1 (18)
P 2 (6)

Trial Status

Recruiting13
Unknown6
Completed4
Not Yet Recruiting2
Terminated1
Withdrawn1

Trial Success Rate

80.0%

Benchmark: 86.5%

Based on 4 completed trials

Clinical Trials (28)

Showing 20 of 20 trials
NCT05289687Phase 2RecruitingPrimary

Daratumumab for Chemotherapy-Refractory Minimal Residual Disease in T Cell ALL

NCT06390319Phase 2RecruitingPrimary

Adding Dasatinib Or Venetoclax To Improve Responses In Children With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (ALL) Or Lymphoma (T-LLY) Or Mixed Phenotype Acute Leukemia (MPAL)

NCT05995028Phase 1RecruitingPrimary

Universal 4SCAR7U Targeting CD7-positive Malignancies

NCT06514794Phase 2RecruitingPrimary

A Phase 2 Study of WU-CART-007, an Anti-CD7 Allogeneic CAR-T Cell Therapy in T-Cell Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma (T-RRex)

NCT07513129Phase 1Not Yet RecruitingPrimary

Venetoclax, Dexamethasone, Bortezomib, and Daratumumab For The Treatment Of Adolescent And Young Adults With Relapsed Or Refractory T-Cell Acute Lymphoblastic Leukemia And T-cell Acute Lymphoblastic Lymphoma

NCT04972942Phase 1RecruitingPrimary

Targeted Immunotherapy After Myeloablative TBI-Based Conditioning & AlloHCT in CAYA With High Risk T-Cell ALL & Lymphoma

NCT05376111Phase 2RecruitingPrimary

Study of Venetoclax Combined With Azacitidine Regimen in Newly Diagnosed T-ALL Patients

NCT06561074Phase 2RecruitingPrimary

A Phase 2 Study to Evaluate Efficacy of Calaspargase Pegol-mknl and Decitabine Combined With Venetoclax in Pediatric, Adolescent, and Young Adult Patients With Relapsed/Refractory T-cell Acute Lymphoblastic Leukemia (T-ALL) and T- Cell Lymphoblastic Lymphoma (T-LLy)

NCT05679895Phase 1RecruitingPrimary

Safety and Efficacy of OC-1 Therapy in Patients With R/R T-ALL/LL

NCT07220993Phase 1Not Yet Recruiting

Novel Unedited Allo Cell Therapy For High Risk T-Cell Malignancies Using CD7-Specific Car T Cells

NCT06316427Phase 1RecruitingPrimary

Autologous and Donor-derived CD7 CAR-T Therapy in Refractory or Relapsed T-cell Malignancies

NCT03690011Phase 1Recruiting

Cell Therapy for High Risk T-Cell Malignancies Using CD7-Specific CAR Expressed On Autologous T Cells

NCT04984356Phase 1CompletedPrimary

A Phase 1 Study of of Anti-CD7 Allogeneic CAR-T Cell Therapy (WU-CART-007) in Patients With Relapsed or Refractory T-ALL/LBL

NCT03081910Phase 1Recruiting

Autologous T-Cells Expressing a Second Generation CAR for Treatment of T-Cell Malignancies Expressing CD5 Antigen

NCT05290155Phase 1Completed

Anti-CD7 CAR-T Cell Therapy for Relapse and Refractory CD7 Positive T Cell Malignancies

NCT06686108Phase 2RecruitingPrimary

Demethylating Agents Combined With Venetoclax for High-risk T-cell Lymphoblastic Lymphoma/Leukemia Post-Transplant Relapse Prevention

NCT05509855Enrolling By InvitationPrimary

A Long-Term Safety Follow-Up Study for Patients Treat With WU-CART-007

NCT05032599Phase 1TerminatedPrimary

Donor-Derived CD5 CAR T Cells in Subjects with Relapsed or Refractory T-Cell Acute Lymphoblastic Leukemia

NCT06420076Phase 1Recruiting

Sequential CAR-T Cells Therapy for CD5/CD7 Positive T-cell Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma Using CD5/CD7-Specific CAR-T Cells

NCT05832125Unknown

Registry of Relapsed/Refractory T-cell Acute Lymphoblastic Leukemia

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