Smallpox
58
2
3
49
Key Insights
Highlights
Success Rate
96% trial completion (above average)
Published Results
20 trials with published results (34%)
Clinical Risk Assessment
Based on trial outcomes
Low Risk
Score: 27/100
3.4%
2 terminated out of 58 trials
96.1%
+9.5% vs benchmark
14%
8 trials in Phase 3/4
41%
20 of 49 completed with results
Key Signals
Data Visualizations
Phase Distribution
Trial Status
Trial Success Rate
Benchmark: 86.6%
Based on 49 completed trials
Clinical Trials (58)
Phase I Trial of an Investigational Small Pox Medication
Study to Assess the Safety and Immunogenicity of TPOXX® When Administered Orally for 28 Days With JYNNEOS
Drug-drug Interaction Study of TPOXX When Co-administered With Phosphate Binders
A Trial to Assess the Safety, Tolerability, and Pharmacokinetics of the Anti-Orthopoxvirus Compound Tecovirimat
Safety, Tolerability and Pharmacokinetics of TPOXX When Administered Orally for 28 Days
Safety, Tolerability and PK of TPOXX in Adults Weighing More Than 120 KG
A Phase 4, Observational Field Study to Evaluate TPOXX in Patients With Smallpox
A Randomized Clinical Trial Investigating the Safety, Reactogenicity, and Immunogenicity After Immunization With an mRNA-based Mpox Vaccine Candidate in Africa
Tecovirimat (ST-246) Treatment for Orthopox Virus Exposure
Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of BSY001 After Single/Multiple Doses.
MVA Post-Event: Administration Timing and Boost Study
A Study to Investigate The Safety, Tolerability, And Immune Response of a Range of Doses of mRNA-1769 Compared With Placebo in Healthy Participants From ≥18 Years of Age to <50 Years of Age
High Dose IMVAMUNE® in Vaccinia-Naive Individuals
Study Evaluating the Bioequivalence of Brincidofovir Form H and Form II Tablets in Healthy Adults
Safety Surveillance Cohort Study of Vaccinia Vaccine (ACAM2000®)
Effect of Dose, Safety, Tolerability of a New Smallpox Vaccine in Adults Without Previous Smallpox Vaccination
Post-licensure Department of Defense (DOD) Screening Accuracy Study in Military Personnel
Safety Surveillance Study of ACAM2000® Vaccinia Vaccine
Dose Study of ACAM2000 Smallpox Vaccine in Previously Vaccinated Adults
Study of the Safety, Tolerability, Pharmacokinetics of NIOCH-14 in Volunteers Aged 18-50 Years