Smallpox
58
2
3
49
Key Insights
Highlights
Success Rate
96% trial completion (above average)
Published Results
20 trials with published results (34%)
Clinical Risk Assessment
Based on trial outcomes
Low Risk
Score: 27/100
3.4%
2 terminated out of 58 trials
96.1%
+9.6% vs benchmark
14%
8 trials in Phase 3/4
41%
20 of 49 completed with results
Key Signals
Data Visualizations
Phase Distribution
Trial Status
Trial Success Rate
Benchmark: 86.5%
Based on 49 completed trials
Clinical Trials (58)
Study to Assess the Safety and Immunogenicity of TPOXX® When Administered Orally for 28 Days With JYNNEOS
A Randomized Clinical Trial Investigating the Safety, Reactogenicity, and Immunogenicity After Immunization With an mRNA-based Mpox Vaccine Candidate in Africa
Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of BSY001 After Single/Multiple Doses.
MVA Post-Event: Administration Timing and Boost Study
A Study to Investigate The Safety, Tolerability, And Immune Response of a Range of Doses of mRNA-1769 Compared With Placebo in Healthy Participants From ≥18 Years of Age to <50 Years of Age
High Dose IMVAMUNE® in Vaccinia-Naive Individuals
Tecovirimat (ST-246) Treatment for Orthopox Virus Exposure
Study Evaluating the Bioequivalence of Brincidofovir Form H and Form II Tablets in Healthy Adults
Drug-drug Interaction Study of TPOXX When Co-administered With Phosphate Binders
Safety, Tolerability and Pharmacokinetics of TPOXX When Administered Orally for 28 Days
Safety, Tolerability and PK of TPOXX in Adults Weighing More Than 120 KG
Safety Surveillance Cohort Study of Vaccinia Vaccine (ACAM2000®)
Effect of Dose, Safety, Tolerability of a New Smallpox Vaccine in Adults Without Previous Smallpox Vaccination
Post-licensure Department of Defense (DOD) Screening Accuracy Study in Military Personnel
Safety Surveillance Study of ACAM2000® Vaccinia Vaccine
Dose Study of ACAM2000 Smallpox Vaccine in Previously Vaccinated Adults
Study of the Safety, Tolerability, Pharmacokinetics of NIOCH-14 in Volunteers Aged 18-50 Years
Study on Immunogenicity, Reactogenicity and Safety of the VACΔ6 Vaccine in Volunteers Aged 18-60 Years
Safety and Tolerability Study of the VAC∆6 Vaccine in Volunteers Aged 18-40 Years
A Phase 4, Observational Field Study to Evaluate TPOXX in Patients With Smallpox