Key Insights

Highlights

Success Rate

66% trial completion

Published Results

70 trials with published results (32%)

Research Maturity

73 completed trials (33% of total)

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 37/100

Termination Rate

16.8%

37 terminated out of 220 trials

Success Rate

66.4%

-20.2% vs benchmark

Late-Stage Pipeline

13%

29 trials in Phase 3/4

Results Transparency

96%

70 of 73 completed with results

Key Signals

70 with results66% success37 terminated

Data Visualizations

Phase Distribution

208Total
Not Applicable (5)
Early P 1 (2)
P 1 (79)
P 2 (93)
P 3 (29)

Trial Status

Completed73
Recruiting45
Terminated37
Active Not Recruiting36
Not Yet Recruiting12
Withdrawn10

Trial Success Rate

66.4%

Benchmark: 86.6%

Based on 73 completed trials

Clinical Trials (220)

Showing 20 of 20 trials
NCT02846623Phase 2Active Not Recruiting

Atezolizumab, Obinutuzumab, and Venetoclax in Treating Patients With Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or Relapsed or Refractory Richter Syndrome

NCT06970743Phase 3Active Not Recruiting

A Study of BGB-16673 Compared to Investigator's Choice in Participants With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Covalent Bruton Tyrosine Kinase (BTK) Inhibitors

NCT06943872Phase 3Recruiting

A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)

NCT06136559Phase 3Recruiting

A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)

NCT04269902Phase 3Recruiting

Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

NCT06973187Phase 3Recruiting

A Study to Evaluate the Safety and Efficacy of BGB-16673 Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

NCT06533579Phase 1Recruiting

Gene Therapy for CD19-Positive Hematologic Malignancies (SENTRY-CD19)

NCT05006716Phase 1Recruiting

A Dose-Escalation and Expansion Study of BGB-16673 in Participants With B-Cell Malignancies

NCT07526597Phase 2Not Yet Recruiting

Study on Treatment Outcome Patterns for Patients With CLL After Discontinuation of BTK Inhibitors

NCT04542824Phase 1Active Not Recruiting

Trial of the Safety and Efficacy of Epcoritamab in Japanese Subjects With Relapsed or Refractory (R/R) B-Cell Non-Hodgkin Lymphoma (R/R B-NHL)

NCT03737981Phase 3Active Not Recruiting

Testing the Addition of a New Anti-cancer Drug, Venetoclax, to the Usual Treatment (Ibrutinib and Obinutuzumab) in Untreated, Older Patients With Chronic Lymphocytic Leukemia

NCT03701282Phase 3Active Not Recruiting

Assessing the Ability of Combination Treatment With Venetoclax to Permit Time Limited Therapy in Chronic Lymphocytic Leukemia

NCT02048813Phase 3Active Not Recruiting

Ibrutinib and Rituximab Compared With Fludarabine Phosphate, Cyclophosphamide, and Rituximab in Treating Patients With Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

NCT04623541Phase 1Active Not Recruiting

Safety and Efficacy Study of Epcoritamab in Subjects With Relapsed/Refractory Chronic Lymphocytic Leukemia and Richter's Syndrome

NCT00923507Recruiting

Natural History Study of Monoclonal B Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL), Lymphoplasmacytic Lymphoma (LPL)/Waldenstrom Macroglobulinemia (WM), and Splenic Marginal Zone Lymphoma (SMZL)

NCT01804686Phase 3Recruiting

A Long-term Extension Study of PCI-32765 (Ibrutinib)

NCT05963074Phase 2Active Not Recruiting

A Study to Customize Ibrutinib Treatment Regimens for Participants With Previously Untreated Chronic Lymphocytic Leukemia

NCT07739459Phase 2Not Yet Recruiting

Study of Zanubrutinib in Older Patients With Previously Untreated Chronic Lymphocytic Leukemia (CLL)

NCT07738887Phase 2Not Yet Recruiting

Epcoritamab Plus Venetoclax Plus Ibrutinib in Patients With Chronic Lymphocytic Leukemia With TP53 Alterations

NCT02756897Phase 2Active Not Recruiting

Venetoclax and Ibrutinib in Treating Patients With Chronic or Small Lymphocytic Leukemia

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