Key Insights

Highlights

Success Rate

69% trial completion

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 47/100

Termination Rate

10.8%

4 terminated out of 37 trials

Success Rate

69.2%

-17.3% vs benchmark

Late-Stage Pipeline

3%

1 trials in Phase 3/4

Results Transparency

111%

10 of 9 completed with results

Key Signals

10 with results69% success

Data Visualizations

Phase Distribution

35Total
P 1 (17)
P 2 (17)
P 3 (1)

Trial Status

Active Not Recruiting10
Completed9
Recruiting7
Terminated4
Withdrawn4
Not Yet Recruiting2

Trial Success Rate

69.2%

Benchmark: 86.6%

Based on 9 completed trials

Clinical Trials (37)

Showing 20 of 20 trials
NCT03899337Phase 2Active Not RecruitingPrimary

A Trial of CHOP-R Therapy, With or Without Acalabrutinib, in Patients With Newly Diagnosed Richter's Syndrome

NCT06863402Phase 2RecruitingPrimary

Nemtabrutinib and Pembrolizumab for the Treatment of Richter Transformation, Diffuse Large B-cell Lymphoma Subtype

NCT03054896Phase 2Active Not RecruitingPrimary

A Phase II Study of Venetoclax in Combination With Dose-adjusted EPOCH-R or R-CHOP for Patients With Richter's Syndrome

NCT06676033Phase 1Active Not Recruiting

Epcoritamab in Chronic Lymphocytic Leukemia and Richter Syndrome

NCT06186648Phase 2RecruitingPrimary

Evaluation of Treatment by Glofitamab in Combination With Rituximab or Obinutuzumab Plus CHOP in Patients With RIchter Syndrome

NCT02332980Phase 2Completed

Pembrolizumab Alone or With Idelalisib or Ibrutinib in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Other Low-Grade B-Cell Non-Hodgkin Lymphomas

NCT03321643Phase 1Active Not Recruiting

Testing the Addition of an Immunotherapy Agent, Atezolizumab, When Given With the Usual Chemo-Immunotherapy Drug Combination (Rituximab Plus Gemcitabine and Oxaliplatin) for Relapsed/Refractory (That Has Come Back or Not Responded to Treatment) Transformed Diffuse Large B-Cell Lymphoma

NCT07220187Phase 3Not Yet RecruitingPrimary

Adding Pirtobrutinib to the Usual Treatment for People With Newly Diagnosed Richter Transformation, The PIRAMID Trial

NCT05672173Phase 2Active Not Recruiting

Lisocabtagene Maraleucel, Nivolumab and Ibrutinib for the Treatment of Richter's Transformation

NCT03479268Phase 1Active Not Recruiting

Pevonedistat and Ibrutinib in Treating Participants With Relapsed or Refractory CLL or Non-Hodgkin Lymphoma

NCT04491370Phase 1Recruiting

Autologous Stem Cell Transplant Followed by Polatuzumab Vedotin in Patients With B-cell Non-Hodgkin and Hodgkin Lymphoma

NCT05388006Phase 2Recruiting

Acalabrutinib, Venetoclax and Durvalumab for the Treatment of Richter Transformation From Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

NCT03534323Phase 1Active Not Recruiting

Duvelisib and Venetoclax in Relapsed or Refractory CLL or SLL or RS

NCT05025800Phase 1Active Not Recruiting

ALX148, Rituximab and Lenalidomide for the Treatment of Indolent and Aggressive B-cell Non-Hodgkin Lymphoma

NCT02846623Phase 2Active Not Recruiting

Atezolizumab, Obinutuzumab, and Venetoclax in Treating Patients With Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or Relapsed or Refractory Richter Syndrome

NCT03884998Phase 1Active Not Recruiting

Copanlisib and Nivolumab in Treating Patients With Richter's Transformation or Transformed Indolent Non-Hodgkin Lymphoma

NCT04679012Phase 2RecruitingPrimary

Polatuzumab Vedotin in Combination With Chemotherapy in Subjects With Richter's Transformation

NCT06735664Phase 1Recruiting

Zanubrutinib in Combination With Odronextamab for the Treatment of Patients With Richter's Transformation

NCT06926205Phase 2RecruitingPrimary

CHOP Plus Mosunetuzumab as First Line in Patients With Richter´s Syndrome: a Phase II Study of the Spanish Group of CLL

NCT04781855Phase 1Withdrawn

Ipilimumab, Ibrutinib, and Nivolumab for the Treatment of Chronic Lymphocytic Leukemia and Richter Transformation

Scroll to load more

Research Network

Activity Timeline