Key Insights

Highlights

Success Rate

77% trial completion

Published Results

75 trials with published results (39%)

Research Maturity

77 completed trials (40% of total)

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 47/100

Termination Rate

11.9%

23 terminated out of 193 trials

Success Rate

77.0%

-9.5% vs benchmark

Late-Stage Pipeline

4%

7 trials in Phase 3/4

Results Transparency

97%

75 of 77 completed with results

Key Signals

75 with results77% success23 terminated

Data Visualizations

Phase Distribution

190Total
Not Applicable (14)
Early P 1 (2)
P 1 (84)
P 2 (83)
P 3 (7)

Trial Status

Completed77
Active Not Recruiting46
Recruiting24
Terminated23
Withdrawn11
Unknown6

Trial Success Rate

77.0%

Benchmark: 86.5%

Based on 77 completed trials

Clinical Trials (193)

Showing 20 of 20 trials
NCT04439292Phase 2Active Not Recruiting

Testing Trametinib and Dabrafenib as a Potential Targeted Treatment in Cancers With BRAF Genetic Changes (MATCH-Subprotocol H)

NCT07340853Phase 1Suspended

CRISPR Delivered Anti-BCMA Car-T Therapy for Relapsed or Refractory Multiple Myeloma

NCT04176718Phase 2Active Not Recruiting

Daratumumab, Carfilzomib, Pomalidomide, Dexamethasone In MM

NCT06171685Phase 2Active Not Recruiting

MMRC Horizon One: RRMM (MMRC-099)

NCT04579523Phase 1Not Yet Recruiting

²¹¹At-OKT10-B10 and Fludarabine Alone or in Combination With Cyclophosphamide and Low-Dose TBI Before Donor Stem Cell Transplant for the Treatment of Newly Diagnosed, Recurrent, or Refractory High-Risk Multiple Myeloma

NCT02465060Phase 2Active Not Recruiting

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

NCT06400251Phase 2Active Not Recruiting

Testing Ipatasertib as Potentially Targeted Treatment in Cancers With AKT Genetic Changes (MATCH - Subprotocol Z1K)

NCT00114101Phase 3Active Not Recruiting

Lenalidomide in Treating Patients With Multiple Myeloma Undergoing Autologous Stem Cell Transplant

NCT06385483Phase 2Active Not Recruiting

Testing Afatinib as Potentially Targeted Treatment in Cancers With EGFR Genetic Changes (MATCH - Subprotocol A)

NCT06303167Phase 2Active Not Recruiting

Testing AZD9291 as Potentially Targeted Treatment in Cancers With EGFR Genetic Changes (MATCH-Subprotocol E)

NCT06357988Phase 2Active Not Recruiting

Testing GDC-0449 (Vismodegib) as Potentially Targeted Treatment in Cancers With Smoothened or Patched 1 Mutant Tumors (MATCH - Subprotocol T)

NCT06360575Phase 2Active Not Recruiting

Testing Crizotinib as Potentially Targeted Treatment in Cancers With MET Exon 14 Deletion Genetic Changes (MATCH - Subprotocol C2)

NCT06308822Phase 2Active Not Recruiting

Testing JNJ-42756493 (Erdafitinib) as Potentially Targeting Treatment in Cancers With FGFR Amplifications (MATCH-Subprotocol K1)

NCT06390826Phase 2Active Not Recruiting

Testing Sunitinib as Potentially Targeted Treatment in Cancers With cKIT Genetic Changes (MATCH - Subprotocol V)

NCT06400238Phase 2Active Not Recruiting

Testing Copanlisib as Potentially Targeting Treatment in Cancers With PTEN Expression (MATCH - Subprotocol Z1H)

NCT06465316Phase 1Recruiting

Testing Teclistamab (TECVAYLI) in Combination With Iberdomide for Relapsed or Refractory Multiple Myeloma

NCT07609030Not ApplicableRecruiting

A Cognitive Training Intervention for Improving Cognitive and Neurological Outcomes in Patients Undergoing Treatment for Relapsed or Refractory Multiple Myeloma or B-cell Non-Hodgkin Lymphoma

NCT03798678Phase 1Active Not Recruiting

CB-839 HCl in Combination With Carfilzomib and Dexamethasone in Treating Patients With Recurrent or Refractory Multiple Myeloma

NCT04439188Phase 2Active Not Recruiting

Testing GSK2636771 as a Potential Targeted Treatment in Cancers With PTEN Loss of Expression (MATCH-Subprotocol P)

NCT04439149Phase 2Active Not Recruiting

Testing GSK2636771 as a Potential Targeted Treatment in Cancers With PTEN Genetic Changes (MATCH-Subprotocol N)

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Research Network

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