Key Insights

Highlights

Success Rate

62% trial completion

Published Results

31 trials with published results (22%)

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 47/100

Termination Rate

14.4%

20 terminated out of 139 trials

Success Rate

62.3%

-24.2% vs benchmark

Late-Stage Pipeline

1%

2 trials in Phase 3/4

Results Transparency

94%

31 of 33 completed with results

Key Signals

31 with results62% success20 terminated

Data Visualizations

Phase Distribution

137Total
Not Applicable (4)
Early P 1 (1)
P 1 (95)
P 2 (35)
P 3 (2)

Trial Status

Recruiting44
Completed33
Active Not Recruiting22
Terminated20
Withdrawn12
Unknown4

Trial Success Rate

62.3%

Benchmark: 86.5%

Based on 33 completed trials

Clinical Trials (139)

Showing 20 of 20 trials
NCT07012044Phase 1Recruiting

A Study to Find the Highest Dose of Cedazuridine and Decitabine Combination With Filgrastim as a Treatment Option After Hematopoietic Stem Cell Transplant in Children With High-Risk Acute Myeloid Leukemia

NCT05146739Phase 1Active Not Recruiting

Highest Dose of Uproleselan in Combination With Fludarabine and Cytarabine for Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Mixed Phenotype Acute Leukemia Relapsed or Refractory That Expresses E-selectin Ligand on the Cell Membrane

NCT05441514Phase 1Completed

Enasidenib in Combination With Cobimetinib for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

NCT06177067Phase 1RecruitingPrimary

Study of Revumenib, Azacitidine, and Venetoclax in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

NCT03670966Phase 1Recruiting

211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome

NCT02890329Phase 1Active Not Recruiting

Ipilimumab and Decitabine in Treating Patients With Relapsed or Refractory Myelodysplastic Syndrome or Acute Myeloid Leukemia

NCT04898894Phase 1Active Not Recruiting

Study of Selinexor and Venetoclax in Combination With Chemotherapy in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

NCT05396859Phase 1Active Not Recruiting

Entrectinib in Combination With ASTX727 for the Treatment of Relapsed/Refractory TP53 Mutated Acute Myeloid Leukemia

NCT04128748Phase 1Recruiting

Liposomal Cytarabine and Daunorubicin (CPX-351) and Quizartinib for the Treatment of Acute Myeloid Leukemia and High Risk Myelodysplastic Syndrome

NCT06484062Phase 1Recruiting

Testing the Anti-cancer Drug, Cirtuvivint, and Its Combination With ASTX727 to Improve Outcomes in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndromes

NCT05263284Phase 1Suspended

8-Chloroadenosine in Combination With Venetoclax for the Treatment of Patients With Relapsed/Refractory Acute Myeloid Leukemia

NCT04435691Phase 1Terminated

Magrolimab, Azacitidine, and Venetoclax for the Treatment of Acute Myeloid Leukemia

NCT03009240Phase 1Completed

Pevonedistat and Decitabine in Treating Patients With High Risk Acute Myeloid Leukemia

NCT05222984Phase 1Active Not Recruiting

Navitoclax, Venetoclax, and Decitabine for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia Previously Treated With Venetoclax

NCT04797767Phase 1Recruiting

Venetoclax and CLAG-M for the Treatment of Acute Myeloid Leukemia and High-Grade Myeloid Neoplasms

NCT04140487Phase 1Recruiting

Azacitidine, Venetoclax, and Gilteritinib in Treating Patients With Recurrent/Refractory FLT3-Mutated Acute Myeloid Leukemia, Chronic Myelomonocytic Leukemia, or High-Risk Myelodysplastic Syndrome/Myeloproliferative Neoplasm

NCT07025564Phase 1Recruiting

MiRisten for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

NCT04975919Phase 2Active Not Recruiting

Venetoclax in Combination With Decitabine and Cedazuridine for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

NCT03132454Phase 1Active Not Recruiting

Palbociclib and Sorafenib, Decitabine, or Dexamethasone in Treating Patients With Recurrent or Refractory Leukemia

NCT06561152Phase 1RecruitingPrimary

Tagraxofusp and Low-Intensity Chemotherapy for CD123-Positive Relapsed or Refractory AML

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