Key Insights

Highlights

Success Rate

76% trial completion

Published Results

54 trials with published results (49%)

Research Maturity

70 completed trials (63% of total)

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 47/100

Termination Rate

19.8%

22 terminated out of 111 trials

Success Rate

76.1%

-10.4% vs benchmark

Late-Stage Pipeline

7%

8 trials in Phase 3/4

Results Transparency

77%

54 of 70 completed with results

Key Signals

54 with results76% success22 terminated

Data Visualizations

Phase Distribution

111Total
Not Applicable (5)
Early P 1 (2)
P 1 (36)
P 2 (60)
P 3 (8)

Trial Status

Completed70
Terminated22
Active Not Recruiting11
Withdrawn6
Recruiting2

Trial Success Rate

76.1%

Benchmark: 86.5%

Based on 70 completed trials

Clinical Trials (111)

Showing 20 of 20 trials
NCT05136196Phase 2Recruiting

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

NCT02465060Phase 2Active Not Recruiting

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

NCT01708941Phase 2Active Not RecruitingPrimary

Ipilimumab With or Without High-Dose Recombinant Interferon Alfa-2b in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery

NCT01274338Phase 3Active Not Recruiting

Ipilimumab or High-Dose Interferon Alfa-2b in Treating Patients With High-Risk Stage III-IV Melanoma That Has Been Removed by Surgery

NCT00937937Phase 2Active Not Recruiting

Dinaciclib in Treating Patients With Stage IV Melanoma

NCT01134614Phase 2Active Not Recruiting

Ipilimumab With or Without Sargramostim in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery

NCT02224781Phase 3Active Not Recruiting

Dabrafenib and Trametinib Followed by Ipilimumab and Nivolumab or Ipilimumab and Nivolumab Followed by Dabrafenib and Trametinib in Treating Patients With Stage III-IV BRAFV600 Melanoma

NCT04514484Phase 1Active Not Recruiting

Testing the Combination of the Anti-cancer Drugs XL184 (Cabozantinib) and Nivolumab in Patients With Advanced Cancer and HIV

NCT04284774Phase 2Active Not Recruiting

Tipifarnib for the Treatment of Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With HRAS Gene Alterations, a Pediatric MATCH Treatment Trial

NCT02965716Phase 2Active Not Recruiting

Talimogene Laherparepvec and Pembrolizumab in Treating Patients With Stage III-IV Melanoma

NCT02298959Phase 1Active Not Recruiting

Testing the PD-1 Antibody, MK3475, Given With Ziv-aflibercept in Patients With Advanced Cancer

NCT06660420Phase 1Recruiting

Phase 1 Dose Escalation and Expansion Study of PRAME T Cell Receptor (TCR) Engineered NK Cells in Participants With Recurrent and/or Refractory Melanoma (PRAMETIME-Mel)

NCT01303341Phase 1Active Not Recruiting

Riluzole and Sorafenib Tosylate in Treating Patients With Advanced Solid Tumors or Melanoma

NCT05717140Phase 1Withdrawn

Aerosolized Sargramostim Added to Immunotherapy for the Treatment of Patients With Metastatic Melanoma to the Lung

NCT01703507Phase 1CompletedPrimary

Phase I Study of Ipilimumab Combined With Whole Brain Radiation Therapy or Radiosurgery for Melanoma

NCT02145910Phase 1WithdrawnPrimary

Vemurafenib Combined With Whole Brain Radiation Therapy or Radiosurgery in Patients With BRAF Mutation-Positive Melanoma and Brain Metastases

NCT01638533Phase 1Completed

Romidepsin in Treating Patients With Lymphoma, Chronic Lymphocytic Leukemia, or Solid Tumors With Liver Dysfunction

NCT01217411Phase 1Terminated

RO4929097 and Whole-Brain Radiation Therapy or Stereotactic Radiosurgery in Treating Patients With Brain Metastases From Breast Cancer

NCT00655655Phase 1Completed

Everolimus and Vatalanib in Treating Patients With Advanced Solid Tumors

NCT02107755Phase 2Completed

Stereotactic Radiation Therapy and Ipilimumab in Treating Patients With Metastatic Melanoma

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