Key Insights

Highlights

Success Rate

70% trial completion

Published Results

34 trials with published results (20%)

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 47/100

Termination Rate

11.4%

19 terminated out of 167 trials

Success Rate

69.8%

-16.7% vs benchmark

Late-Stage Pipeline

4%

6 trials in Phase 3/4

Results Transparency

77%

34 of 44 completed with results

Key Signals

34 with results70% success19 terminated

Data Visualizations

Phase Distribution

163Total
Not Applicable (13)
Early P 1 (17)
P 1 (74)
P 2 (53)
P 3 (6)

Trial Status

Completed44
Recruiting42
Active Not Recruiting22
Unknown20
Terminated19
Withdrawn12

Trial Success Rate

69.8%

Benchmark: 86.5%

Based on 44 completed trials

Clinical Trials (167)

Showing 20 of 20 trials
NCT06069726Phase 2RecruitingPrimary

A Multicenter Trial to Identify Optimal Atezolizumab Biomarkers in the Setting of Recurrent Glioblastoma. The MOAB Trial

NCT05902169Phase 3Recruiting

Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM

NCT06325683Phase 2Suspended

Anti-Lag-3 (Relatlimab) and Anti-PD-1 Blockade (Nivolumab) Versus Standard of Care (Lomustine) for the Treatment of Patients With Recurrent Glioblastoma

NCT05303467Phase 1Recruiting

A Feasibility Study to Evaluate the Safety of the TheraSphere Glioblastoma (GBM) Device in Patients With Recurrent GBM

NCT07739017Phase 1Not Yet RecruitingPrimary

OLIG2 Inhibitor CT-179 for Recurrent and Newly-diagnosed Glioblastoma

NCT07416188Phase 1RecruitingPrimary

Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma

NCT05284643Not ApplicableRecruitingPrimary

Spectroscopic MRI, Proton Therapy, and Avastin for Recurrent Glioblastoma

NCT02208362Phase 1Active Not RecruitingPrimary

Genetically Modified T-cells in Treating Patients With Recurrent or Refractory Malignant Glioma

NCT06910306Not ApplicableRecruitingPrimary

Alpha Radiation Emitters Device (DaRT) for the Treatment of Recurrent Glioblastoma

NCT03115333Not ApplicableActive Not Recruiting

DSC-MRI in Measuring rCBV for Early Response to Bevacizumab in Patients With Recurrent Glioblastoma

NCT07712770Early Phase 1Not Yet Recruiting

Pilot Radioembolisation Clinical Trial Assessing Safety and Efficacy in Recurrent Glioma

NCT03896568Phase 1Recruiting

MSC-DNX-2401 in Treating Patients With Recurrent High-Grade Glioma

NCT05039281Phase 1Active Not RecruitingPrimary

Atezolizumab and Cabozantinib for the Treatment of Recurrent Glioblastoma

NCT05660369Phase 1Recruiting

CARv3-TEAM-E T Cells in Glioblastoma

NCT06344130Phase 1Recruiting

Hypofractionation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma

NCT04903795Phase 1Not Yet Recruiting

BRiTE - Bispecific T Cell Engager for Patients With Glioblastoma

NCT02974621Phase 2Active Not RecruitingPrimary

Cediranib Maleate and Olaparib Compared to Bevacizumab in Treating Patients With Recurrent Glioblastoma

NCT04214392Phase 1Active Not RecruitingPrimary

Chimeric Antigen Receptor (CAR) T Cells With a Chlorotoxin Tumor-Targeting Domain for the Treatment of MMP2+ Recurrent or Progressive Glioblastoma

NCT06815029Phase 1Recruiting

Intracranial Genetically Modified Immune Cells (TGFβR2KO/IL13Rα2 CAR T-Cells) for the Treatment of Recurrent or Progressive Glioblastoma or Grade 3 or 4 IDH-Mutant Astrocytoma

NCT07541781Phase 1Recruiting

Sitagliptin in Recurrent/Progressive Grade 4 Glioma

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