Key Insights

Highlights

Success Rate

70% trial completion

Published Results

33 trials with published results (20%)

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 47/100

Termination Rate

11.7%

19 terminated out of 163 trials

Success Rate

69.8%

-16.7% vs benchmark

Late-Stage Pipeline

4%

6 trials in Phase 3/4

Results Transparency

75%

33 of 44 completed with results

Key Signals

33 with results70% success19 terminated

Data Visualizations

Phase Distribution

159Total
Not Applicable (13)
Early P 1 (15)
P 1 (72)
P 2 (53)
P 3 (6)

Trial Status

Completed44
Recruiting40
Active Not Recruiting21
Unknown20
Terminated19
Withdrawn12

Trial Success Rate

69.8%

Benchmark: 86.5%

Based on 44 completed trials

Clinical Trials (163)

Showing 20 of 20 trials
NCT07416188Phase 1Not Yet RecruitingPrimary

Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma

NCT03115333Not ApplicableActive Not Recruiting

DSC-MRI in Measuring rCBV for Early Response to Bevacizumab in Patients With Recurrent Glioblastoma

NCT05557292Phase 1Terminated

RMC-5552 Monotherapy in Adult Subjects With Recurrent Glioblastoma

NCT04003649Phase 1Active Not RecruitingPrimary

IL13Ra2-CAR T Cells With or Without Nivolumab and Ipilimumab in Treating Patients With GBM

NCT05091866Early Phase 1Terminated

Natural Progesterone for the Treatment of Recurrent Glioblastoma

NCT06325683Phase 2Suspended

Anti-Lag-3 (Relatlimab) and Anti-PD-1 Blockade (Nivolumab) Versus Standard of Care (Lomustine) for the Treatment of Patients With Recurrent Glioblastoma

NCT07346144Phase 1Recruiting

Study of an AAV Mediated Dual-Payload Gene Therapy in Patients With High Grade Glioma

NCT05303467Phase 1Recruiting

A Feasibility Study to Evaluate the Safety of the TheraSphere Glioblastoma (GBM) Device in Patients With Recurrent GBM

NCT06389591Phase 1Active Not RecruitingPrimary

RNA-Lipid Particle (RNA-LP) Vaccines for Recurrent Adult Glioblastoma (GBM)

NCT07297212Phase 2RecruitingPrimary

A Clinical Trial Testing the Safety of the Investigational Drug Pumitamig (BNT327) and How Well it Works in Patients With Recurrent Glioblastoma

NCT06039709Phase 1RecruitingPrimary

Sonodynamic Therapy in Patients With Recurrent GBM

NCT04903795Phase 1Not Yet Recruiting

BRiTE - Bispecific T Cell Engager for Patients With Glioblastoma

NCT05902169Phase 3Recruiting

Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM

NCT07551336Phase 1Recruiting

Dual-Targeting CAR-NK Cells for Recurrent/Progressive Glioblastoma and High-Grade Glioma

NCT07541781Phase 1Not Yet Recruiting

Sitagliptin in Recurrent/Progressive Grade 4 Glioma

NCT06069726Phase 2RecruitingPrimary

A Multicenter Trial to Identify Optimal Atezolizumab Biomarkers in the Setting of Recurrent Glioblastoma. The MOAB Trial

NCT06894225Phase 2SuspendedPrimary

Proof-of-Concept Study of ACT001 in Adult Patients With Recurrent Glioblastoma Harbouring STAT3-High Signature

NCT07538128Early Phase 1RecruitingPrimary

Evaluating Safety, Tolerability, and Preliminary Efficacy of YSCH-01 Monotherapy and in Combination With Atezolizumab for Recurrent Glioblastoma

NCT04988750Not ApplicableCompletedPrimary

Evaluate the Safety and Preliminary Efficacy of the Combination of NaviFUS System With Re-irradiation for rGBM Patients

NCT04528680Phase 1Active Not Recruiting

Ultrasound-based Blood-brain Barrier Opening and Albumin-bound Paclitaxel and Carboplatin for Recurrent Glioblastoma

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