Key Insights

Highlights

Success Rate

56% trial completion

Published Results

32 trials with published results (28%)

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 60/100

Termination Rate

16.8%

19 terminated out of 113 trials

Success Rate

55.8%

-30.7% vs benchmark

Late-Stage Pipeline

1%

1 trials in Phase 3/4

Results Transparency

133%

32 of 24 completed with results

Key Signals

32 with results56% success19 terminated

Data Visualizations

Phase Distribution

113Total
Not Applicable (1)
Early P 1 (1)
P 1 (80)
P 2 (30)
P 3 (1)

Trial Status

Recruiting32
Completed24
Active Not Recruiting21
Terminated19
Withdrawn11
Suspended4

Trial Success Rate

55.8%

Benchmark: 86.5%

Based on 24 completed trials

Clinical Trials (113)

Showing 20 of 20 trials
NCT07012044Phase 1Recruiting

A Study to Find the Highest Dose of Cedazuridine and Decitabine Combination With Filgrastim as a Treatment Option After Hematopoietic Stem Cell Transplant in Children With High-Risk Acute Myeloid Leukemia

NCT05146739Phase 1Active Not Recruiting

Highest Dose of Uproleselan in Combination With Fludarabine and Cytarabine for Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Mixed Phenotype Acute Leukemia Relapsed or Refractory That Expresses E-selectin Ligand on the Cell Membrane

NCT05441514Phase 1CompletedPrimary

Enasidenib in Combination With Cobimetinib for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

NCT02727803Phase 2Recruiting

Personalized NK Cell Therapy in CBT

NCT03670966Phase 1Recruiting

211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome

NCT02890329Phase 1Active Not Recruiting

Ipilimumab and Decitabine in Treating Patients With Relapsed or Refractory Myelodysplastic Syndrome or Acute Myeloid Leukemia

NCT05396859Phase 1Active Not Recruiting

Entrectinib in Combination With ASTX727 for the Treatment of Relapsed/Refractory TP53 Mutated Acute Myeloid Leukemia

NCT04128748Phase 1Recruiting

Liposomal Cytarabine and Daunorubicin (CPX-351) and Quizartinib for the Treatment of Acute Myeloid Leukemia and High Risk Myelodysplastic Syndrome

NCT06484062Phase 1Recruiting

Testing the Anti-cancer Drug, Cirtuvivint, and Its Combination With ASTX727 to Improve Outcomes in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndromes

NCT05263284Phase 1Suspended

8-Chloroadenosine in Combination With Venetoclax for the Treatment of Patients With Relapsed/Refractory Acute Myeloid Leukemia

NCT04435691Phase 1Terminated

Magrolimab, Azacitidine, and Venetoclax for the Treatment of Acute Myeloid Leukemia

NCT03009240Phase 1Completed

Pevonedistat and Decitabine in Treating Patients With High Risk Acute Myeloid Leukemia

NCT05222984Phase 1Active Not RecruitingPrimary

Navitoclax, Venetoclax, and Decitabine for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia Previously Treated With Venetoclax

NCT04140487Phase 1RecruitingPrimary

Azacitidine, Venetoclax, and Gilteritinib in Treating Patients With Recurrent/Refractory FLT3-Mutated Acute Myeloid Leukemia, Chronic Myelomonocytic Leukemia, or High-Risk Myelodysplastic Syndrome/Myeloproliferative Neoplasm

NCT07025564Phase 1RecruitingPrimary

MiRisten for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

NCT04975919Phase 2Active Not Recruiting

Venetoclax in Combination With Decitabine and Cedazuridine for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

NCT03132454Phase 1Active Not Recruiting

Palbociclib and Sorafenib, Decitabine, or Dexamethasone in Treating Patients With Recurrent or Refractory Leukemia

NCT02392572Phase 1Recruiting

ONC201 in Treating Patients With Relapsed or Refractory Acute Leukemia or High-Risk Myelodysplastic Syndrome

NCT03983824Phase 1Active Not RecruitingPrimary

Testing the Addition of an Anti-cancer Drug, M3814, to the Usual Treatment (Mitoxantrone, Etoposide, and Cytarabine) for Relapsed or Refractory Acute Myeloid Leukemia

NCT03289910Phase 2Active Not Recruiting

Topotecan Hydrochloride and Carboplatin With or Without Veliparib in Treating Advanced Myeloproliferative Disorders and Acute Myeloid Leukemia or Chronic Myelomonocytic Leukemia

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