Key Insights

Highlights

Success Rate

25% trial completion

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 85/100

Termination Rate

15.8%

3 terminated out of 19 trials

Success Rate

25.0%

-61.5% vs benchmark

Late-Stage Pipeline

5%

1 trials in Phase 3/4

Results Transparency

0%

0 of 1 completed with results

Key Signals

25% success

Data Visualizations

Phase Distribution

16Total
P 1 (10)
P 2 (5)
P 3 (1)

Trial Status

Recruiting10
Terminated3
Not Yet Recruiting2
Unknown2
Active Not Recruiting1
Completed1

Trial Success Rate

25.0%

Benchmark: 86.5%

Based on 1 completed trials

Clinical Trials (19)

Showing 19 of 19 trials
NCT06321081Phase 2RecruitingPrimary

ICE Study: Combination of Irinotecan Plus Cetuximab and Envafolimab as a Rechallenge Regimen in mCRC

NCT04776655Phase 3Active Not Recruiting

Study in mCRC Patients RAS/BRAF wt Tissue and RAS Mutated LIquid BIopsy to Compare FOLFIRI Plus CetuxiMAb or BevacizumaB

NCT07686445Phase 1Not Yet Recruiting

A Study of AN4035 in Advanced Cancers With RAS Mutations and High CEACAM5 Expression

NCT07678593Phase 1Not Yet Recruiting

A Study of GFH276 Combined With Cetuximab or Chemotherapy in Participants With Solid Tumors and Pancreatic Ductal Adenocarcinoma (PDAC) Harboring RAS Mutation

NCT04678648Phase 1Recruiting

A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies

NCT07252479Phase 1Recruiting

Evaluation of RAS Inhibitor Treatment in Participants With Advanced or Metastatic Solid Tumors Harboring RAS Mutations

NCT06922591Phase 1Recruiting

Study to Evaluate the Safety, Tolerability & Efficacy of TNG462 in Combination in PDAC & NSCLC Patients

NCT06287463Phase 1Terminated

Study of DCC-3084 in Participants With Advanced Malignancies Driven by the Mitogen-Activated Protein Kinase (MAPK) Pathway

NCT04395495RecruitingPrimary

RASopathy Biorepository

NCT06299839Phase 1RecruitingPrimary

PAS-004 in Patients With Advanced Solid Tumors

NCT07121829Phase 1Terminated

Tovorafenib (DAY101) or in Combination With Pimasertib for Participants With Melanoma and Other Solid Tumors

NCT05340621Phase 1CompletedPrimary

NAUTILUS: OKI-179 Plus Binimetinib in Patients with Advanced Solid Tumors in the RAS Pathway (Phase 1b) and NRAS-mutated Melanoma (Phase 2)

NCT05831995Phase 1Terminated

Safety and Effectiveness of ABM-168 in Adults with Advanced Solid Tumors.

NCT04286360RecruitingPrimary

Hematological Anomalies in Children With Rasopathy

NCT06206096Phase 2Recruiting

PD-1 Antibody Plus Bevacizumab and CAPOX as First-line Treatment for RAS-mut MSS mCRC

NCT06229340Phase 2RecruitingPrimary

Leflunomide or Combination of MEK Inhibitor and Hydroxychloroquine for Refractory Patients With RAS Mutations

NCT06218810Phase 2Recruiting

Cadonilimab in Combination With Bevacizumab and FOLFOX Regimen for the First-Line Treatment of Advanced Unresectable MSS-Type, RAS-Mutated Metastatic Colorectal Cancer

NCT04194359Phase 2Unknown

Sintilimab (IBI308) Combined With Bevacizumab + XELOX Regimen in Metastatic Colorectal Cancer

NCT04852250Unknown

Centralized Tumour Board and Secondary Intervention Rate in mCRC

Showing all 19 trials

Research Network

Activity Timeline